Purpose To evaluate the prostag landins(PG) levels and to identify the effect of dexamethasone(DXM) on PG in response to photochemical insult in rat retina. Methods The experiments were performed on 36 SD rats which were separated into two groups,control and treated groups,and the latter received daily intraperitoneal injections of DXM (1 mg/kg) for 5 consecutive days,starting 3 days before light exposure.The animals were continually exposed to green fluorescent light(510-560 nm)with an illuminance level of (1900 plusmn;106.9)lx for 24 hrs.The retinal concentration of PGE 2 and 6-keto-PGF1 alpha; were tested at 6hrs,1,3,7 and 14 days after light exposure. Results The PGE2 and 6-keto-PGF1 alpha; levels of the control groups (37.50 plusmn;2.75,48.06 plusmn;4.0 4,81.90 plusmn;4.89) pg/mg and (4.68 plusmn;0.69,7.50 plusmn;0.57,10.40 plusmn;0.71) pg/mg had significantly higher values than those of the treated rats(20.60 plusmn;4.28,37.36 plusmn; 3.34,54.85 plusmn;4.57) pg/mg and (2.50 plusmn;0.59,4．68 plusmn;0.81,6.87 plusmn;1.10)pg/mg (P lt;0.01) after 6 hrs,1 and 3 days light exposure respectively. Conclusion By inhibition of PG synthesis,the DXM may play an ameliorative effect on retinal photochemical injury of rats. (Chin J Ocul Fundus Dis,1999,15:94-96)
Citation： ZHANG Junjun,YAN Mi,ZHANG Min.. Prostaglandins in rat retina during photochemical damage . Chinese Journal of Ocular Fundus Diseases, 1999, 15(2): 94-96. doi: Copy