Gao Ping , Hui Yannian , Ma Jixian , et al.
  • Department of Ophthalmology,XinJing Hospital,Fourth Military Medical University,Xian 710032,China;
Retinal diseases/etiology; Hyperplasia/etiology; Interleukin-6; Tumor necrosis factor-alpha; Immunohistochemistry.
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Purpose To investigate the expression of the interleukin-6(IL-6)and tumor necrosis factor alpha(TNF- alpha;) in epiretinal membranes(ERM) of eyes with proliferative vitreoretinopathy(PVR). Methods Nineteen epiretinal membranes were obtained form eyes undergoing vitrectomy for retinal detachment complicated with PVR and observed by immunohistochemical methods. Results Expression of IL-6 and TNF- alpha; were observed in 12 and 15 membranes respectively with positive staining mostly in extracellular matrix of epiretinal membranes.Only one membrane showed positive to IL-6 intracellularly,and expression for IL-6 and TNF- alpha; simultaneously in membranes. Conclusion The findings indicate that IL-6、and TNF- alpha;might be involved in the development of PVR. (Chin J Ocul Fundus Dis,1998,14:219-221)

Citation： Gao Ping,Hui Yannian,Ma Jixian,et al.. An immunohistochemical study of Il-6,TNF-α in epiretinal membreanes.. Chinese Journal of Ocular Fundus Diseases, 1998, 14(4): 219-221. doi: Copy