PURPOSE: To produce monoclonal antibodies directed against tumor-associated antigens expressed of retinoblastoma-derived tissue culture cell line SO-RBS0. METHODS:Hybridization was performed and the specificity of the antibody was tested by immunofluorescent and immunohistochemical methods. RESULTS:Two hybridomas secreted specific monoclonal antibody against retinoblastoma cells were produced ,and the isotype of the monoclonal antibody was IgG2a CONCLUION:The monoclonal antibodies were specific and highly active against retinoblastoma cells and might be used as immunoconjugate.
Citation： Li Yongping,FengGuangguang,Ning Bo,et al. STUDIES OF MONOCLONAL ANTIBODY AGAINST RETINOBLASTOMA CELLS. Chinese Journal of Ocular Fundus Diseases, 1997, 13(1): 3-5. doi: Copy