Liu Ningpu , Osborne NN , Zhang Hulrong
  • Dept.Ophthalmology,Third Hospital,Beijing Medical University,Beijing 100083;
Retinal pigment epithelium; Cell culture; Epidermal growth factor; Muscarinic receptor; Inositol phosphates
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

In thiis study,we show thai carbachol stimulates the accumulation of inositol phosphates(InsPs)in human rellnal pigment epithelium (RPE)cells and atropine blocks the carbachol-induced effect ,suggesting the existence of musearinie acelyleholine receptors in human RPE cells. In contrast,noradrenaline,serotonin, cpidermal growth factor (EGF),isoproterenol,and NECA (5'-[N-ethyl]-carboxamido-adenosine)do not influence the basal levels of InsPs.Moreover,isoprmerenol and NECA do not affect the carhaehol elevated levels of InsPs.EGF,howcvcr,does potentiate the carhaehol stimulated elevation of InsPs in a dose-dependent manner ,suggesting an interaction between EGF and musearinie receptors in cultured human RPE cells. （Chin J Ocul Fundus Dis,1994,10:220-222）

Citation： Liu Ningpu,Osborne NN,Zhang Hulrong. EGF POTENTIATES THE MUSCARINIC RECEPTOR-INDUCED STIMULATION OF INOSITOL PHOSPHATES IN RPE CELLS:ANALYSIS OF RECEPTOR INTERACTION. Chinese Journal of Ocular Fundus Diseases, 1994, 10(4): 220-222. doi: Copy