Albendazole for Hepatic Cystic Echinococcosis: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Tao ¹² , LIU Yali ¹³ ,  YANG Kehu ¹³ , JIN Fengling ⁴ , JING Tao ⁵ , CAO Nong ⁶ , TIAN Jinhui ¹³ , MA Bin ¹³ , YANG Lin ⁷

Corresponding author：

YANG Kehu, Email: yangkh2006@163.com

Keywords：

hepatic cystic echinococcosis; Albendazole; Systematic review

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Objective 　To evaluate the efficacy and safety of albendazole (ABZ) in the treatment of hepatic cystic echinococcosis (HCE).
Methods 　Randomised trials and quasi-randomised trials of ABZ for treating HCE were sought by electronic and handsearching. Studies were analyzed according to the methods recommended by The Cochrane Collabration.
Results 　Only two studies met the inclusion criteria. The quality of both was graded as B. One study compared ABZ with mebendazole (MBZ). This showed similar effective rates in the numbers of cysts and cases [RR 1.19, 95%CI (0.97, 1.46)] and [RR 1.35, 95%CI (0.91, 2.00)]. The other study compared ABZ plus surgery with surgery alone.This showed that efficacy was comparable between one-month treatment of ABZ plus surgery and surgery alone [RR 1.63, 95%CI (0.90, 2.93)]; but that 3 months of treatment with ABZ plus surgery could significantly improve the efficacy compared to surgery alone [RR 1.89, 95% CI (1.09, 3.29)].
Conclusion 　In the treatment of HCE, ABZ has similar efficacy on MBZ; long-term (3 months) treatment of ABZ given before surgery may improve the efficacy when compared to surgery alone. More high-quality randomised trials are required to define the role of ABZ in treating HCE.

Citation： WANG Tao,LIU Yali,YANG Kehu,JIN Fengling,JING Tao,CAO Nong,TIAN Jinhui,MA Bin,YANG Lin. Albendazole for Hepatic Cystic Echinococcosis: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2007, 07(11): 789-793. doi: Copy

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2.	Chai JJ, Meng HB, Jiao W, et al. Efficacy of ablendazole emulsion in treatment of 212 patients with cystic echinococcosis. Chinese Journal of Parasitology and Parasitic Diseases, 2001, 19(3): 129-134．.
3.	CSBTS, MOH. Diagnostic criteria and treatment principle of echinococcosis. The National Standards of the People’s Republic of China, 1997, GB7013.
4.	Tan JZ, Wang LW. Observision of clinical curative effect with abendazole longer therapy in hydatid disease, edemic aviso. Endemic Disease Bulletin, 1995, 10(1): 67-68.
5.	Zhang HL, Zhu QY, Jiing Q, et al. A comparative trial of clinical efficacy of emulsion albendazole in treatment of hepatic cystic echinococcosis. Chinese Journal of Parasitic Disease Control, 2002, 15(4): 228-229.
6.	Qian XM. Progress in surgical treatment of hydatid disease in China clinical analysis of 2005 surgical case. Chinese Medical Journal, 1995, 108(4): 2952.
7.	Wen H, Zou PF, Yang WG, et al. Abendazole chemotherapy for human cystic and alveolar echinococcosis in Northwestern China. Trans Rsoc Trop MedHyg, 1994, 340-343.
8.	温浩, 姚秉礼, 邹培范, 等. 高效液相色谱法测定人体血液胆汁和包虫囊液的丙硫咪唑及代谢产物的含量. 地方病通报, 1989, 4(4): 52-54.
9.	柴君杰, 孟贺巴特, 焦伟, 等. 阿苯达唑乳剂治疗肝囊型包虫病212例临床疗效观察. 中国寄生虫学与寄生虫病杂志, 2001, 19(3): 129-134．.
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11.	谭家忠, 王龙文. 阿苯达唑长期治疗肝包虫的临床观察. 地方病通报. 1995, 10(1): 67-68.
12.	张贺玲, 朱其银, 荆强, 等. 两种剂型阿苯达唑治疗肝囊型包虫病的疗效对照观察, 中国寄生虫病防治杂志, 2002, 15(4): 228-229.
13.	Mohamed AE, Yasawy MI, Al-Karawi MA. Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease. Hepatogastroenterology, 1998, 45(23): 1690-1694.
14.	Gupta SK, Schantz PM, Donaldson JS. Recurrent hydatid disease after therapy with albendazole. Pediatr Infect Dis J, 1993, 12(6): 535-536.
15.	Morris DL, Taylor. Sensitivity to albendazole sulphoxide of echinococcus granulosus scoleces in man. Lancet, 1986, 2(8514): 1035.
16.	Davis A, Pawlowski ZS, Dixon H. Multicetre clinical trials of benzimidazole carbamates in human echinococcosis. Bulletin of the World Health Organization, 1986, 64(3): 383-388.
17.	Davis A, Dixon H, Pawlowski ZS. Multicetre clinical trials of benzimidazole carbamates in human cystic echinococcosis (phase 2). Bulletin of the World Health Organization, 1989, 67(5): 503-508.
18.	Wilcox MH, Morris DL, Bailey JW. Serology in patients treated with albendazole for hydatid disease. J R Soc Med, 1988, 81(12): 714-717.
19.	Mohammed SK, Yousuf D, Ghulam NY. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study. Gastroenterology, 1993, 104: 1452-1459.
20.	Cristiana F, Bruno DV, Antonella T. Long-Term Evaluation of Patients with Hydatidosis Treated with Benzimidazole Carbamates. Clinical Infectious Diseases, 1999, 29: 304-309.
21.	Evangelos C, Tsimoyiannis PS, Kyriaki J. Moutesidou.Periopertive Benzimidazole Therapy in Human Hydaid Liver Disease. Int Surg, 1995, 80: 131-133.
22.	Byt Todorov K, Vutova G, Mechkov P. Georgiev. Chemotherapy of human cystic echinococcosis: comparative efficacy of mebendazole and albendazole. Annals of Tropical Medicine and Parasitology, 1992, 86(1): 59-66.
23.	Gil-Grande LA, Rodriguez-Caabeiro F, Prieto JG, et al. Randomised controlled trial of efficacy of albendazole in intra-abdominal hydatid disease. Lancet, 1993, 342(8882): 1269-1272.

1. Wen H, Yao BL, Zou PF, et al. Determination of albendazole and RTS metabolites in serum bile and cystic fluid by HPLC. Endemic Disease Bulletin, 1989, 4(4): 52-54.
2. Chai JJ, Meng HB, Jiao W, et al. Efficacy of ablendazole emulsion in treatment of 212 patients with cystic echinococcosis. Chinese Journal of Parasitology and Parasitic Diseases, 2001, 19(3): 129-134．.
3. CSBTS, MOH. Diagnostic criteria and treatment principle of echinococcosis. The National Standards of the People’s Republic of China, 1997, GB7013.
4. Tan JZ, Wang LW. Observision of clinical curative effect with abendazole longer therapy in hydatid disease, edemic aviso. Endemic Disease Bulletin, 1995, 10(1): 67-68.
5. Zhang HL, Zhu QY, Jiing Q, et al. A comparative trial of clinical efficacy of emulsion albendazole in treatment of hepatic cystic echinococcosis. Chinese Journal of Parasitic Disease Control, 2002, 15(4): 228-229.
6. Qian XM. Progress in surgical treatment of hydatid disease in China clinical analysis of 2005 surgical case. Chinese Medical Journal, 1995, 108(4): 2952.
7. Wen H, Zou PF, Yang WG, et al. Abendazole chemotherapy for human cystic and alveolar echinococcosis in Northwestern China. Trans Rsoc Trop MedHyg, 1994, 340-343.
8. 温浩, 姚秉礼, 邹培范, 等. 高效液相色谱法测定人体血液胆汁和包虫囊液的丙硫咪唑及代谢产物的含量. 地方病通报, 1989, 4(4): 52-54.
9. 柴君杰, 孟贺巴特, 焦伟, 等. 阿苯达唑乳剂治疗肝囊型包虫病212例临床疗效观察. 中国寄生虫学与寄生虫病杂志, 2001, 19(3): 129-134．.
10. 国家技术监督局, 中华人民共和国卫生部. 包虫病诊断标准及处理原则. 中华人民共和国国家标准, 1997, GB7013.
11. 谭家忠, 王龙文. 阿苯达唑长期治疗肝包虫的临床观察. 地方病通报. 1995, 10(1): 67-68.
12. 张贺玲, 朱其银, 荆强, 等. 两种剂型阿苯达唑治疗肝囊型包虫病的疗效对照观察, 中国寄生虫病防治杂志, 2002, 15(4): 228-229.
13. Mohamed AE, Yasawy MI, Al-Karawi MA. Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease. Hepatogastroenterology, 1998, 45(23): 1690-1694.
14. Gupta SK, Schantz PM, Donaldson JS. Recurrent hydatid disease after therapy with albendazole. Pediatr Infect Dis J, 1993, 12(6): 535-536.
15. Morris DL, Taylor. Sensitivity to albendazole sulphoxide of echinococcus granulosus scoleces in man. Lancet, 1986, 2(8514): 1035.
16. Davis A, Pawlowski ZS, Dixon H. Multicetre clinical trials of benzimidazole carbamates in human echinococcosis. Bulletin of the World Health Organization, 1986, 64(3): 383-388.
17. Davis A, Dixon H, Pawlowski ZS. Multicetre clinical trials of benzimidazole carbamates in human cystic echinococcosis (phase 2). Bulletin of the World Health Organization, 1989, 67(5): 503-508.
18. Wilcox MH, Morris DL, Bailey JW. Serology in patients treated with albendazole for hydatid disease. J R Soc Med, 1988, 81(12): 714-717.
19. Mohammed SK, Yousuf D, Ghulam NY. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study. Gastroenterology, 1993, 104: 1452-1459.
20. Cristiana F, Bruno DV, Antonella T. Long-Term Evaluation of Patients with Hydatidosis Treated with Benzimidazole Carbamates. Clinical Infectious Diseases, 1999, 29: 304-309.
21. Evangelos C, Tsimoyiannis PS, Kyriaki J. Moutesidou.Periopertive Benzimidazole Therapy in Human Hydaid Liver Disease. Int Surg, 1995, 80: 131-133.
22. Byt Todorov K, Vutova G, Mechkov P. Georgiev. Chemotherapy of human cystic echinococcosis: comparative efficacy of mebendazole and albendazole. Annals of Tropical Medicine and Parasitology, 1992, 86(1): 59-66.
23. Gil-Grande LA, Rodriguez-Caabeiro F, Prieto JG, et al. Randomised controlled trial of efficacy of albendazole in intra-abdominal hydatid disease. Lancet, 1993, 342(8882): 1269-1272.

Chinese Journal of Evidence-Based Medicine

Albendazole for Hepatic Cystic Echinococcosis: A Systematic Review

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