Analysis of Serum IL-6 And TNF-αLevels in Children With Obstructive Sleep Apnea Syndrome_Chinese Journal of Evidence-Based Medicine

Authors：

CHEN Jie ¹ , YANG Jun ² , YANG Wenwei ³ , WU Hao ²

1 Shanghai JiaoTong University Medical College Children Medical Center ENT-Neck Department, Shanghai 2001272 Shanghai JiaoTong University Medical College Xin-hua hospital ENT-Neck Department, Shanghai 2000923 Shanghai Huangpu center hospital Immunity Department, Shanghai 200001;

Corresponding author：

Keywords：

OSAS; IL-6; TNF-α

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Objective 　To investigate the levels of IL-6 and TNF-α in children with obstructive sleep apnea syndrome (OSAS) and to determine their clinical significance.
Methods 　One hundred children with OSAS in our department from August 2005 to February 2006, and 40 healthy children were enrolled in the study. The serum levels of IL-6 and TNF-α were measured.
Results 　Serum levels of IL-6 and TNF-α were significantly higher in patients with OSAS than those in the control group (P lt;0.05). Both IL-6 and TNF-α were not correlated with AHI.
Conclusion 　It is concluded that OSAS is a chronic inflammatory process. A close correlation was observed between high levels of IL-6 and TNF-α and OSAS. High levels of IL-6 and TNF-α account for the risk factors in the development of cardiovascular diseases in children with OSAS.

Citation： CHEN Jie,YANG Jun,YANG Wenwei,WU Hao. Analysis of Serum IL-6 And TNF-αLevels in Children With Obstructive Sleep Apnea Syndrome. Chinese Journal of Evidence-Based Medicine, 2007, 07(7): 547-549. doi: Copy

1.	Liu YC, Lu XY, Cui ZZ, et al. Epidemiologic survey of 2-12 years children’s sleeping in 8 city of China. Sleep Medicine, 2004, 1(1): 4-7.
2.	刘玺诚, 卢秀英, 崔振泽, 等. 全国8城市2～12岁儿童睡眠状况流行病学调查. 睡眠医学, 2004, 1(1): 4-7.
3.	Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease interleukin-6 and the risk of mortality in order women: The women’ health and aging study. Circulation, 2001, 103(7): 947-953.
4.	Schulz R, Mahmoudi S, Hattar K, et al.Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Am J Respir Crit Care Med, 2000, 162(2): 566-570.
5.	Monaco C, Andreakos E, Young S, et al. T cell-mediated signaling to vascular endothelium: induction of cytokines,chemokines, and tissue factor. J Leukoc Biol, 2002, 71(4): 659-668 .
6.	Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of Creactive protine and Interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway preassure. Circulation, 2003, 107(8): 1129-1134.
7.	Riha RL, Brander P, Vennelle M, et al. Tumour necrosis factor- (–308) gene polymorphism in obstructive sleep apnoea–hypopnoea syndrome. Eur Respir J, 2005, 26(32): 673-678.
8.	Biasucci LM, Liuzzo G, Fantuzzi G, et al. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increase tisk of in-hospital coronary events. Circulation, 1999, 99(16): 2079-2084.
9.	Vansan RS, Sullivan LM, Roubenoff R, et al. Inflammatory markers and risks of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation, 2003, 107(11): 1486-1491.
10.	Tauman R, Ivanenko A, Louise P, et al. Plasma C-Reactive Protein Levels Among Children With Sleep-Disordered Breathing. Pediatrics, 2004, 113(6): 564-569.
11.	Takuya Y, Minoguchi K, Matsuo H, et al. Elevated Levels of C-Reactive Protein and Interleukin-6 in Patients With Obstructive Sleep Apnea Syndrome Are Decreased by Nasal Continuous Positive Airway Pressure. Circulation, 2003, 107(11): 1129-1133.

1. Liu YC, Lu XY, Cui ZZ, et al. Epidemiologic survey of 2-12 years children’s sleeping in 8 city of China. Sleep Medicine, 2004, 1(1): 4-7.
2. 刘玺诚, 卢秀英, 崔振泽, 等. 全国8城市2～12岁儿童睡眠状况流行病学调查. 睡眠医学, 2004, 1(1): 4-7.
3. Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease interleukin-6 and the risk of mortality in order women: The women’ health and aging study. Circulation, 2001, 103(7): 947-953.
4. Schulz R, Mahmoudi S, Hattar K, et al.Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Am J Respir Crit Care Med, 2000, 162(2): 566-570.
5. Monaco C, Andreakos E, Young S, et al. T cell-mediated signaling to vascular endothelium: induction of cytokines,chemokines, and tissue factor. J Leukoc Biol, 2002, 71(4): 659-668 .
6. Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of Creactive protine and Interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway preassure. Circulation, 2003, 107(8): 1129-1134.
7. Riha RL, Brander P, Vennelle M, et al. Tumour necrosis factor- (–308) gene polymorphism in obstructive sleep apnoea–hypopnoea syndrome. Eur Respir J, 2005, 26(32): 673-678.
8. Biasucci LM, Liuzzo G, Fantuzzi G, et al. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increase tisk of in-hospital coronary events. Circulation, 1999, 99(16): 2079-2084.
9. Vansan RS, Sullivan LM, Roubenoff R, et al. Inflammatory markers and risks of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation, 2003, 107(11): 1486-1491.
10. Tauman R, Ivanenko A, Louise P, et al. Plasma C-Reactive Protein Levels Among Children With Sleep-Disordered Breathing. Pediatrics, 2004, 113(6): 564-569.
11. Takuya Y, Minoguchi K, Matsuo H, et al. Elevated Levels of C-Reactive Protein and Interleukin-6 in Patients With Obstructive Sleep Apnea Syndrome Are Decreased by Nasal Continuous Positive Airway Pressure. Circulation, 2003, 107(11): 1129-1133.

Chinese Journal of Evidence-Based Medicine

Analysis of Serum IL-6 And TNF-αLevels in Children With Obstructive Sleep Apnea Syndrome

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