Clinical Efficacy of Cordyceps Sinensis for Chronic Kidney Diseases: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

XU Fenglei ¹ , HUAN Wenying ¹ ,  WU Taixiang ² , QIU Xa ¹ , ZHANG Hong ¹ , LIU Xinhua ¹

1.The Central Hospital of Karamay, Karamay 834000, China 2.Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

WU Taixiang, Email: xufl2004@hotmail.com

Keywords：

Cordyceps sinensis; Jinshuibao; Chronic kidney diseases; Systematic review; Meta-analysis; Randomized controlled trial

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Objective 　To assess the clinical efficacy of Cordyceps sinensis in the treatment of chronic kidney diseases.
Methods 　Randomized or quasi-randomized controlled trials (RCTs or quasi-RCTs) were identified from MEDLINE (1996 to Oct. 2005), EMbase (1984 to Oct. 2005), The Cochrane Central Register of controlled Trials (Issue 3, 2005) and CBMdisc (1978 to Oct. 2005). We also handsearched related published and unpublished data and their references. Data were extracted and evaluated by two reviewers independently with a designed extraction form. RevMan4.2.7 software was used for data analysis.
Results 　One RCT and 5 quasi-RCTs involving 434 patients were included. Results of meta-analysis were presented as follows: ① Response rate: five studies showed that, compared with the blank control group, significant differences were observed after the treatment with Cordyceps (RR 2.13, 95%CI 1.06 to 4.26); one study showed that there was no difference between Cordyceps and Shenyankangfu tablet (RR 2.17, 95%CI 0.73 to 6.460). ② Total effective rate: five studies showed that, compared with the blank control group, significant differences were observed after the treatment with Cordyceps (RR1.94, 95 %CI 1.14 to 3.30); one study showed that there was no difference between Cordyceps and Shenyankangfu tablet (RR 1.39, 95%CI 0.89 to 2.16). ③ Adverse reactions: adverse reactions were rare only with mild symptoms.
Conclusions 　Cordyceps sinensis may improve the response rate and total effective rate of chronic kidney diseases. More high quality trials are required.

Citation： XU Fenglei,HUAN Wenying,WU Taixiang,QIU Xa,ZHANG Hong,LIU Xinhua. Clinical Efficacy of Cordyceps Sinensis for Chronic Kidney Diseases: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2006, 06(11): 804-808. doi: Copy

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2.	季晖, 李战, 濮祖茂. 人工虫草对庆大霉素所致大鼠急性肾损伤的保护作用. 中国药科大学学报, 1996; 27(4): 245~239.
3.	杨焕荣, 张春梅, 马景春, 等. 人工虫草对慢性肾功能衰竭患者肾功能及免疫功能的影响. 中西医结合实用临床急救, 1999; 6(4): 168~169.
4.	贾峥嵘. 卡托普利联用冬虫夏草制剂对2型糖尿病肾病早期微白蛋白尿的影响. 中国中西医结合急救杂志, 1999; 12(6): 566~567.
5.	宋怀方, 林令华, 宋莹莹. 金水宝胶囊在治疗糖尿病肾病中的作用观察. 药学进展, 2000; 24(2): 116~118.
6.	尹继明, 廖文燕, 江晓生. 冬虫夏草对单纯性血尿转阴效果的观察. 广州医药, 2000; 31(4): 65~66.
7.	邓隆银, 文晓冬, 樊雷. 冬虫夏草制剂对原发性肾病综合征复发的影响及其作用机制的临床研究. 中国中西医结合肾病杂志, 2001; 2(6): 335~336.
8.	全毅红, 徐力. 虫草制剂治疗慢性肾功能衰竭的临床研究. 湖北中医杂志, 2004; 26(5): 11~12.
9.	钟清, 陈思静, 李曼丽. 人工虫草治疗慢性肾炎的临床观察. 广东医学, 2002; 23 suppl: 178.
10.	Luo M. General situation of research on Cordyceps sinensis. Chinese Pharmaceutical Journal, 1989; 9(8): 361.
11.	Ji H, Li Z, Fu ZM. Protection of artificial Cordyceps for acute renal injury in rats induced by cidomycin. Journal of China Pharmaceutical University, 1996; 27(4): 245–249.
12.	Yang HR, Zhang CM, Ma JC, et al. Influences of artifical cordyceps sinensis on renal functions and immune functions in patients with chronic renal failure. Practical clinical emergency journal of Integrated Traditional Chinese with Western Medicine, 1999; 6(4): 168–169.
13.	Jia ZR. Influences of treatment with captopril combined with cordyceps preparation on microalbuminuria of early-stage diabetic nephropathy in 2 type diabetes. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, 1999; 12(6): 566–567.
14.	Song HF, Lin LH, Song YY. The clinical effects of Jinshuibao capsules in the treatment of diabetic nephropathy. Progress in Pharmaceutical Sciences, 2000; 24(2): 116–118.
15.	Yin JM, Liao WY, Jiang XS. Effect of cordyceps on simple hematuria. Guangzhou Medical Journal, 2000; 31(4): 65–66.
16.	Deng LY , Wen XD, Fan L. Clinical study on Effect and mechanism of cordyceps on primary nephrotic syndrome. Chinese Journal of Integrated Traditional and Western Nephrology, 2001; 2(6): 335–336.
17.	Quan YH, Xu L. Clinical study on chronic renal failure delayed by Chongcao preparation. Hubei Journal of Traditional Chinese Medicine, 2004; 26(5): 11–12.
18.	Zhong Q, Chen SJ, LI ML. Clinical observation of cordyceps in the treatment of chronic nephritis. Guangdong Medical Journal, 2002; 23suppl: 178.
19.	Juni P, A ltm an DG, EgerM. Assessing the quality of controlled clinical trails. BMJ, 2001; 323 (7303) : 42–46.

1. 罗敏. 冬虫夏草的研究概况. 中国药学杂志, 1989; 9(8): 361.
2. 季晖, 李战, 濮祖茂. 人工虫草对庆大霉素所致大鼠急性肾损伤的保护作用. 中国药科大学学报, 1996; 27(4): 245~239.
3. 杨焕荣, 张春梅, 马景春, 等. 人工虫草对慢性肾功能衰竭患者肾功能及免疫功能的影响. 中西医结合实用临床急救, 1999; 6(4): 168~169.
4. 贾峥嵘. 卡托普利联用冬虫夏草制剂对2型糖尿病肾病早期微白蛋白尿的影响. 中国中西医结合急救杂志, 1999; 12(6): 566~567.
5. 宋怀方, 林令华, 宋莹莹. 金水宝胶囊在治疗糖尿病肾病中的作用观察. 药学进展, 2000; 24(2): 116~118.
6. 尹继明, 廖文燕, 江晓生. 冬虫夏草对单纯性血尿转阴效果的观察. 广州医药, 2000; 31(4): 65~66.
7. 邓隆银, 文晓冬, 樊雷. 冬虫夏草制剂对原发性肾病综合征复发的影响及其作用机制的临床研究. 中国中西医结合肾病杂志, 2001; 2(6): 335~336.
8. 全毅红, 徐力. 虫草制剂治疗慢性肾功能衰竭的临床研究. 湖北中医杂志, 2004; 26(5): 11~12.
9. 钟清, 陈思静, 李曼丽. 人工虫草治疗慢性肾炎的临床观察. 广东医学, 2002; 23 suppl: 178.
10. Luo M. General situation of research on Cordyceps sinensis. Chinese Pharmaceutical Journal, 1989; 9(8): 361.
11. Ji H, Li Z, Fu ZM. Protection of artificial Cordyceps for acute renal injury in rats induced by cidomycin. Journal of China Pharmaceutical University, 1996; 27(4): 245–249.
12. Yang HR, Zhang CM, Ma JC, et al. Influences of artifical cordyceps sinensis on renal functions and immune functions in patients with chronic renal failure. Practical clinical emergency journal of Integrated Traditional Chinese with Western Medicine, 1999; 6(4): 168–169.
13. Jia ZR. Influences of treatment with captopril combined with cordyceps preparation on microalbuminuria of early-stage diabetic nephropathy in 2 type diabetes. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, 1999; 12(6): 566–567.
14. Song HF, Lin LH, Song YY. The clinical effects of Jinshuibao capsules in the treatment of diabetic nephropathy. Progress in Pharmaceutical Sciences, 2000; 24(2): 116–118.
15. Yin JM, Liao WY, Jiang XS. Effect of cordyceps on simple hematuria. Guangzhou Medical Journal, 2000; 31(4): 65–66.
16. Deng LY , Wen XD, Fan L. Clinical study on Effect and mechanism of cordyceps on primary nephrotic syndrome. Chinese Journal of Integrated Traditional and Western Nephrology, 2001; 2(6): 335–336.
17. Quan YH, Xu L. Clinical study on chronic renal failure delayed by Chongcao preparation. Hubei Journal of Traditional Chinese Medicine, 2004; 26(5): 11–12.
18. Zhong Q, Chen SJ, LI ML. Clinical observation of cordyceps in the treatment of chronic nephritis. Guangdong Medical Journal, 2002; 23suppl: 178.
19. Juni P, A ltm an DG, EgerM. Assessing the quality of controlled clinical trails. BMJ, 2001; 323 (7303) : 42–46.

Chinese Journal of Evidence-Based Medicine

Clinical Efficacy of Cordyceps Sinensis for Chronic Kidney Diseases: A Systematic Review

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