Clinical Evidences for Topiramate in Intractable Epilepsy Treating_Chinese Journal of Evidence-Based Medicine

Authors：

ZHANG Shuying , ZOU Xiaoyi

Department of Neurology,West China Hospital,Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Topiramate/Topamax; Epilepsy; Efficacy and safety; Clinical evidence

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We searched The Cochrane Library（Issue 3, 2005）, MEDLINE（1996-2005） ,CMCC（1996-2005）, VIP（1996-2005） ,CNKI（1996-2005） to summarize the available evidence of topiramate for an intractable epilepsy. After scanning all these articles, we identified 11 articles including meta-analysis, randomised controlled trials and systematic reviews to evaluate. Topiramate offered an alternative in the treament for intractable epilepsy, especially for partial epilepsy, and its efficacy was proven. Patients had good tolerance. And no intercross effects with the traditional anti-epileptic drugs were found. So topiramate had broad clinical value. The primary dosage of topiramate was 200mg/d. The sustaining dosage was 400-600mg/d. And we didn＇t recommend the dosage of more than 600mg/d.

Citation： ZHANG Shuying,ZOU Xiaoyi. Clinical Evidences for Topiramate in Intractable Epilepsy Treating. Chinese Journal of Evidence-Based Medicine, 2006, 06(2): 142-145. doi: Copy

1.	Manish PB,Anita G,Michael G,et al.Clinical experience with topiramate.Epilepsia,2002; 43(Suppl 7):198-199.
2.	Hou XZ.Neurology.The 3th Edition.Beijing:The People’s Press; 1996.175-179.侯熙照.神经病学.第3版.北京:人民卫生出版社; 1996.175～179.
3.	Bob Phillips,Chris Ball,Dave Sackett,et al.Levels of Evidence and Grades.Recommendation.Oxford Centre for Evidence-based Medicine Levels of Evidence,May 2001.
4.	Elterman RD,Glauser TA,Wyllie R,et al.A double-blind randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children.Neurology,1999; 52(7):1338-1344.
5.	Privitera M,Fincham R,Penry,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-、800-and 1000-mg daily dosages.Neurology,1996; 46(6):1678-1683.
6.	Faught E,Wilder BJ,Ramsay RE,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-、400-and 600-mg daily dosages.Neurology,1996; 46(6):1684-1690.
7.	Jakob C,Frederik A,Pouls JH,et al.Randomized,concentration controlled trial of topiramate in refractory focal epilepsy.Neurology,2003; 61(9):1210-1218.
8.	Yen DJ,Yu HY,Guo YC,et al.A double-blind,placebo-controlled study of topiramate in adult patients with refractory partial epilepsy.Epilepsia,2000; 41(9):1162-1166.
9.	Lee B-1,Kim W-J,Kim D-K,et al.Topiramate in medically intractable partial epilepsies:Double-blind,placebo-controlled randomized parallel group trial.Epilepsia,1999; 40(12):1767-1774.
10.	Sharief M,Viteri C,Ben-Menachem E,et al.Double-blind,placebo-controlled study of topiramate in patients with refractory partial epilepsy.Epilepsy research,1996; 25(3):217-214.
11.	Tassinari CA,Michelucci R,Chauvel P,et al.Double-blind,placebo-controlled trial of topiramate (600mg daily)for treatment of refractory partial epilepsy.Epilepsia,1996; 37(8):763-768.
12.	Jette NJ,Marson AG,Hutton JL.Topiramate add-on for drug-resistant partial epilepsy[M/CD].The Cochrane Database of Systematic Reviews 2002,Issue 3.Art.No:CD001417.DOI:10.1002/14651858.CD001417.
13.	Reife RA,Pledger GW.Topiramate as adjunctive therapy in refractory partial epilepsy:pooled analysis of data from five double-blind,placebo-controlled trials.Epilepsia,1997; 138(suppl1):S31-33.
14.	Zheng LZ,Zhang HJ,Song XX.Topiramate in intractable epilepsy:A meta-analysis.Journal of Medical Reaserch,2005; 34(2):30-32.郑乃智,张慧娟,宋旭霞.托吡酯添加治疗难治性癫痫Meta分析.医学研究通讯,2005; 34(2):30～32.
15.	Lesaffre E,Boon P,Pledger GW.The value of the number-needed-to-treat method in antiepileptic drug trials.Epilepsia,2002; 41(4):440-446.

1. Manish PB,Anita G,Michael G,et al.Clinical experience with topiramate.Epilepsia,2002; 43(Suppl 7):198-199.
2. Hou XZ.Neurology.The 3th Edition.Beijing:The People’s Press; 1996.175-179.侯熙照.神经病学.第3版.北京:人民卫生出版社; 1996.175～179.
3. Bob Phillips,Chris Ball,Dave Sackett,et al.Levels of Evidence and Grades.Recommendation.Oxford Centre for Evidence-based Medicine Levels of Evidence,May 2001.
4. Elterman RD,Glauser TA,Wyllie R,et al.A double-blind randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children.Neurology,1999; 52(7):1338-1344.
5. Privitera M,Fincham R,Penry,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-、800-and 1000-mg daily dosages.Neurology,1996; 46(6):1678-1683.
6. Faught E,Wilder BJ,Ramsay RE,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-、400-and 600-mg daily dosages.Neurology,1996; 46(6):1684-1690.
7. Jakob C,Frederik A,Pouls JH,et al.Randomized,concentration controlled trial of topiramate in refractory focal epilepsy.Neurology,2003; 61(9):1210-1218.
8. Yen DJ,Yu HY,Guo YC,et al.A double-blind,placebo-controlled study of topiramate in adult patients with refractory partial epilepsy.Epilepsia,2000; 41(9):1162-1166.
9. Lee B-1,Kim W-J,Kim D-K,et al.Topiramate in medically intractable partial epilepsies:Double-blind,placebo-controlled randomized parallel group trial.Epilepsia,1999; 40(12):1767-1774.
10. Sharief M,Viteri C,Ben-Menachem E,et al.Double-blind,placebo-controlled study of topiramate in patients with refractory partial epilepsy.Epilepsy research,1996; 25(3):217-214.
11. Tassinari CA,Michelucci R,Chauvel P,et al.Double-blind,placebo-controlled trial of topiramate (600mg daily)for treatment of refractory partial epilepsy.Epilepsia,1996; 37(8):763-768.
12. Jette NJ,Marson AG,Hutton JL.Topiramate add-on for drug-resistant partial epilepsy[M/CD].The Cochrane Database of Systematic Reviews 2002,Issue 3.Art.No:CD001417.DOI:10.1002/14651858.CD001417.
13. Reife RA,Pledger GW.Topiramate as adjunctive therapy in refractory partial epilepsy:pooled analysis of data from five double-blind,placebo-controlled trials.Epilepsia,1997; 138(suppl1):S31-33.
14. Zheng LZ,Zhang HJ,Song XX.Topiramate in intractable epilepsy:A meta-analysis.Journal of Medical Reaserch,2005; 34(2):30-32.郑乃智,张慧娟,宋旭霞.托吡酯添加治疗难治性癫痫Meta分析.医学研究通讯,2005; 34(2):30～32.
15. Lesaffre E,Boon P,Pledger GW.The value of the number-needed-to-treat method in antiepileptic drug trials.Epilepsia,2002; 41(4):440-446.

Chinese Journal of Evidence-Based Medicine

Clinical Evidences for Topiramate in Intractable Epilepsy Treating

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