Retrospective Analysis of Multifocal Motor Neuropathy Cases Published in Chinese_Chinese Journal of Evidence-Based Medicine

Authors：

ZHONG Ping ¹ ,  HE Li ²

1. Department of Neurology, Shanghai Traditional and Western Medicine Integrated Hospital, Shanghai 200082, China 2. Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

HE Li, Email: heli2003new@126.com

Keywords：

Mulifocal motor neuropathy; Distal limb weakness; Muscle amyotrophy; Conduction block of motor nerve; Literature assessment

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Objective 　To study the clinical characteristics of mulifocal motor neuropathy.
Methods　 Patients records in China Biological Medicine Database (CBM-disc 1980-2005)and WanFang Database were searched. Demographic data, clinical manifestations, electrophysiology, and laboratory findings on multifocal motor neuropathy were analyzed. Results Of the total 80 patients, 61 cases were males, and 19 were females. A single limb weakness began in all the patients. Weakness was usually accentuated distally(95.3%), accompanied by muscle amyotrophy(76.3%) and fasciculation(46.3%). Reflexes were reduced (96.4%). Sensory impairment and cranial involvement were rare. 92.1% of the patients showed conduction block of motor nerve.
Results　 Of the total 80 patients, 61 cases were males, and 19 were females. A single limb weakness began in all the patients. Weakness was usually accentuated distally(95.3%), accompanied by muscle amyotrophy(76.3%) and fasciculation(46.3%). Reflexes were reduced (96.4%). Sensory impairment and cranial involvement were rare. 92.1% of the patients showed conduction block of motor nerve.
Conclusions 　Clinical features about multifocal motor neuropathy are a single distal limb weakness, muscle amyotrophy, and conduction block of motor nerve. MMN should be differentiated from motor neuron disease and chronic inflammatory demyelinating polyneuropathy.

Citation： ZHONG Ping,HE Li. Retrospective Analysis of Multifocal Motor Neuropathy Cases Published in Chinese. Chinese Journal of Evidence-Based Medicine, 2006, 06(4): 305-309. doi: Copy

1.	汤景乾，梁圣彬，王振金等. 神经电生理检测对多灶性运动神经病诊断价值的初步研究. 中华神经科杂志，2004；37（1）：59～61.
2.	杨荣东.多灶性运动神经病3例报告. 川北医学院学报，2003；18（1）：148～151.
3.	蒋荣峰，张光伟，李光勤等. 多灶性运动神经病四例报告. 中华神经科杂志, 2001; 34(3): 167.
4.	葛建新，姜俊珍.多灶性运动神经病2例报告. 河南实用神经病学, 2002; 2（5）: 96.
5.	李存江，王向波，邢华芳. 多灶性运动神经病的临床研究. 北京医学, 2002; 24（2）: 75～76.
6.	徐敏，贾建平，张津. 多灶性运动神经病10例分析. 中风与神经疾病杂志, 2003; 20（6）: 541～543.
7.	刘明生，崔丽英，李晓光等.多灶性运动神经病的临床和神经电生理研究. 中华神经科杂志, 2004; 37（1）: 62～64.
8.	蒋智林，叶静，范骏等.多灶性运动神经病的临床、电生理和病理分析. 中国实用内科杂志, 2003; 23（2）: 110～111.
9.	黄东祥，李艳.多灶性运动神经病的临床特征和诊断（附1例报告）. 脑与神经疾病杂志, 2002; 10（2）: 117.
10.	罗丹红，黄鉴政. 多灶性运动神经病2例报告. 中风与神经疾病杂志；2004，21（1）：84.
11.	吕宪民，冯凯，马建国等.多灶性运动神经病1例. 中国煤炭工业医学杂志, 2004; 1（7）: 91～92.
12.	王立军，康德瑄，钟延丰等. 多灶性运动神经病电生理诊断的初步研究. 中华物理医学杂志, 1998: 4（4）: 72.
13.	姚茂元，包兴昌.多灶性运动神经病2例. 南通医学院学报, 2002; 22（2）: 219.
14.	Olney RK, Lewis RA, Putnam TD, Campellone JV Jr. Consensus criteria for the diagnosis of multifocal motor neuropathy. Muscle Nerve, 2003; 27(1):117-121.
15.	TANG JQ, LIANG Sheng-bin, WANG Zhen-jin, et al. Preliminary research on electroneurophysiological examination for diagnosis of multifocal motor neuropathy. Chinese Journal Neurology, 2004; 37(1):59-61.
16.	Yang RD. Multifocal motor neuropathy 3 cases report. Journal of North Sichuan Medical College, 2003; 18（1）: 148-151.
17.	JIANG RF, ZHONG Guang-wei, LI Guang-qin, et al. Multifocal motor neuropathy 4 cases report. Chinese Journal Neurology, 2001; 34(3): 167.
18.	GE JX, JIANG Jun-zhen. Multifocal motor neuropathy 2 cases report. Henan Journal of Practical Nervous Diseases, 2002; 5（2）: 96.
19.	LI CJ, WANG Xiao-bao, XING Hua-fang. Clinical study in multifocal motor neuropathy[J]. Beijing Medicine Journal; 2002: 24（2）: 75-76.
20.	XU M, JIA JP, ZHANG Jin. Multifocal motor neuropathy 10 cases report. Journal of Apoplexy and Nervous Diseases; 2003；20（6）: 541-543.
21.	LIU MS, CUI Li-ying, LI Xiao-guang, et al. The clinical and electrophysiological features of multifocal motor neuropathy. Chinese Journal Neurology; 2004: 37（1）: 62-64.
22.	JIANG ZL, YE Jing, FAN Jun, et al. Analysis of clinic and electrophysiology and pathology on multifocal motor neuropathy. Chinese Journal of Practical Internal Medicine, 2003 ; 23（2）: 110-111.
23.	HUANG DX, LI Yan. The clinical characteristics and diagnosis of mulifocal motor neuropathy. Journal of Brain and Nervous Diseases, 2002: 10（2）: 117.
24.	Luo DH, HUANG Jian-zheng. Multifocal motor neuropathy 2 cases report. Journal of Apoplexy and Nervous Diseases; 2004, 21（1）: 84.
25.	LV XM, FENG Kai, MA Jian-guo, et al. Multifocal motor neuropathy 1 cases report. Chinese Journal of Coal Industry Medicine, 2004; 1（7）: 91-92.
26.	WANG LJ, KANG De-xuan, ZHONG Yan-feng,et al. Electrophysiological Diagnosis of Multifocal Motor Neuropathy. Chinese Journal of Physical medicine, 1998; 4（4）: 72.
27.	YAO MY, BAO Xing-chang. Multifocal motor neuropathy 2 cases report. Journal of Nantong Medical College, 2002; 22（2）: 219.
28.	Van den Berg-Vos RM, Franssen H, Wokke JH, et al. Multifocal motor neuropathy diagnostic criteria that predict the response to immunoglobulin treatment. Ann Neurol, 2000, 48(425): 919-926.
29.	Olney RK, Consensus criteria for the diagnosis of paritial conduction block. Muscle Nerve, 1999, 22(Suppl 8): 225-229.
30.	Katz JS, Wolfe GI, Bryan WW, et al. Multifocal motor neuropathy human sera block distal motor neuropathy. Neurology, 1997, 48(63): 700-707.
31.	Nobile-Orazio E. Multifocal motor neuropathy. J Neuroimmunol, 2001, 115(21): 4-18.

1. 汤景乾，梁圣彬，王振金等. 神经电生理检测对多灶性运动神经病诊断价值的初步研究. 中华神经科杂志，2004；37（1）：59～61.
2. 杨荣东.多灶性运动神经病3例报告. 川北医学院学报，2003；18（1）：148～151.
3. 蒋荣峰，张光伟，李光勤等. 多灶性运动神经病四例报告. 中华神经科杂志, 2001; 34(3): 167.
4. 葛建新，姜俊珍.多灶性运动神经病2例报告. 河南实用神经病学, 2002; 2（5）: 96.
5. 李存江，王向波，邢华芳. 多灶性运动神经病的临床研究. 北京医学, 2002; 24（2）: 75～76.
6. 徐敏，贾建平，张津. 多灶性运动神经病10例分析. 中风与神经疾病杂志, 2003; 20（6）: 541～543.
7. 刘明生，崔丽英，李晓光等.多灶性运动神经病的临床和神经电生理研究. 中华神经科杂志, 2004; 37（1）: 62～64.
8. 蒋智林，叶静，范骏等.多灶性运动神经病的临床、电生理和病理分析. 中国实用内科杂志, 2003; 23（2）: 110～111.
9. 黄东祥，李艳.多灶性运动神经病的临床特征和诊断（附1例报告）. 脑与神经疾病杂志, 2002; 10（2）: 117.
10. 罗丹红，黄鉴政. 多灶性运动神经病2例报告. 中风与神经疾病杂志；2004，21（1）：84.
11. 吕宪民，冯凯，马建国等.多灶性运动神经病1例. 中国煤炭工业医学杂志, 2004; 1（7）: 91～92.
12. 王立军，康德瑄，钟延丰等. 多灶性运动神经病电生理诊断的初步研究. 中华物理医学杂志, 1998: 4（4）: 72.
13. 姚茂元，包兴昌.多灶性运动神经病2例. 南通医学院学报, 2002; 22（2）: 219.
14. Olney RK, Lewis RA, Putnam TD, Campellone JV Jr. Consensus criteria for the diagnosis of multifocal motor neuropathy. Muscle Nerve, 2003; 27(1):117-121.
15. TANG JQ, LIANG Sheng-bin, WANG Zhen-jin, et al. Preliminary research on electroneurophysiological examination for diagnosis of multifocal motor neuropathy. Chinese Journal Neurology, 2004; 37(1):59-61.
16. Yang RD. Multifocal motor neuropathy 3 cases report. Journal of North Sichuan Medical College, 2003; 18（1）: 148-151.
17. JIANG RF, ZHONG Guang-wei, LI Guang-qin, et al. Multifocal motor neuropathy 4 cases report. Chinese Journal Neurology, 2001; 34(3): 167.
18. GE JX, JIANG Jun-zhen. Multifocal motor neuropathy 2 cases report. Henan Journal of Practical Nervous Diseases, 2002; 5（2）: 96.
19. LI CJ, WANG Xiao-bao, XING Hua-fang. Clinical study in multifocal motor neuropathy[J]. Beijing Medicine Journal; 2002: 24（2）: 75-76.
20. XU M, JIA JP, ZHANG Jin. Multifocal motor neuropathy 10 cases report. Journal of Apoplexy and Nervous Diseases; 2003；20（6）: 541-543.
21. LIU MS, CUI Li-ying, LI Xiao-guang, et al. The clinical and electrophysiological features of multifocal motor neuropathy. Chinese Journal Neurology; 2004: 37（1）: 62-64.
22. JIANG ZL, YE Jing, FAN Jun, et al. Analysis of clinic and electrophysiology and pathology on multifocal motor neuropathy. Chinese Journal of Practical Internal Medicine, 2003 ; 23（2）: 110-111.
23. HUANG DX, LI Yan. The clinical characteristics and diagnosis of mulifocal motor neuropathy. Journal of Brain and Nervous Diseases, 2002: 10（2）: 117.
24. Luo DH, HUANG Jian-zheng. Multifocal motor neuropathy 2 cases report. Journal of Apoplexy and Nervous Diseases; 2004, 21（1）: 84.
25. LV XM, FENG Kai, MA Jian-guo, et al. Multifocal motor neuropathy 1 cases report. Chinese Journal of Coal Industry Medicine, 2004; 1（7）: 91-92.
26. WANG LJ, KANG De-xuan, ZHONG Yan-feng,et al. Electrophysiological Diagnosis of Multifocal Motor Neuropathy. Chinese Journal of Physical medicine, 1998; 4（4）: 72.
27. YAO MY, BAO Xing-chang. Multifocal motor neuropathy 2 cases report. Journal of Nantong Medical College, 2002; 22（2）: 219.
28. Van den Berg-Vos RM, Franssen H, Wokke JH, et al. Multifocal motor neuropathy diagnostic criteria that predict the response to immunoglobulin treatment. Ann Neurol, 2000, 48(425): 919-926.
29. Olney RK, Consensus criteria for the diagnosis of paritial conduction block. Muscle Nerve, 1999, 22(Suppl 8): 225-229.
30. Katz JS, Wolfe GI, Bryan WW, et al. Multifocal motor neuropathy human sera block distal motor neuropathy. Neurology, 1997, 48(63): 700-707.
31. Nobile-Orazio E. Multifocal motor neuropathy. J Neuroimmunol, 2001, 115(21): 4-18.

Chinese Journal of Evidence-Based Medicine

Retrospective Analysis of Multifocal Motor Neuropathy Cases Published in Chinese

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