Clinical Efficacy of Pueraria for Acute Cerebral Infarction_Chinese Journal of Evidence-Based Medicine

Authors：

TAN Yan ¹ ,  LIU Ming ² , Wu Bo ²

1. Department of Neurology, Guangzhou Brain Hospitol, Guangzhou 510370 ,China 2. Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIU Ming, Email: wyplm@mail.sc.cninfo.net

Keywords：

Pueraria; Acute cerebral infarction; Systematic reviewe

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Objective 　To assess the efficacy and safety of pueraria for acute cerebral infarction.
Methods 　We searched MEDLINE, EMBASE, CBM, and the Chinese Stroke Clinical Trials Database. The search was conducted in Feb., 2006. Data were extracted and assessed by two reviewers independently. Revman 4.2 software was used for statistical analysis.
Results 　Nineteen potentially eligible trials were identified, of which 14 (1 141 patients) were included. Only one trial reported the death or disability rate at the end of 6-month follow-up (the difference between the two groups was not significant). Meta-analysis of 11 trials invovling the improvement of neurological deficit indicated that pueraria was significantly more effective than the control group [OR 3.04, 95%CI 2.11, 4.39].
Conclusions 　Pueraria might improve the short-term neurological deficit of patients with acute cerebral infarction. But the methodological quality of all the included trials is poor, reliable conclusions can not be drawn from the present data. More high-quality randomized controlled trials are required.

Citation： TAN Yan,LIU Ming,Wu Bo. Clinical Efficacy of Pueraria for Acute Cerebral Infarction. Chinese Journal of Evidence-Based Medicine, 2006, 06(7): 494-499. doi: Copy

1.	刘鸣, 张世洪. 临床试验中的意向处理分析. 英国医学杂志 (中文版), 2001; 4(4): 223-224.
2.	吴祖舜, 高俊凤, 陈玉山, 等. 普润 (葛根素) 葡萄糖注射液联合低分子肝素 (海普甯) 治疗急性脑梗死的疗效观察－附30例报告. 脑与神经疾病杂志, 2004; 12(1): 53～54,58.
3.	巢建新, 叶明. 葛根素治疗急性缺血性脑卒中的临床研究. 广东药学, 2004; 14(3): 38～39.
4.	宋春江, 李秋茹, 钟晓闵, 等. 葛根素治疗脑梗死40例疗效观察. 四川医学, 2005; 26(3): 306 ～307.
5.	石云, 马湖蕊. 葛根素治疗急性脑梗塞32例疗效观察. 云南中医中药杂志, 2005; 26(3): 7-8.
6.	荣培红, 林海, 查鹏洲. 葛根素联合降纤酶治疗急性脑梗塞48例. 陕西中医, 2004; 25(2): 123～124.
7.	王吉, 管仁莲. 葛根素与脑活素联合治疗急性脑梗塞的效果. 实用医药杂志, 2002; 19(7): 502.
8.	赵路清. 葛根素治疗急性脑梗死的临床观察. 实用临床医药杂志, 2004; 8(2): 76.
9.	吴新艳. 葛根素加川芎嗪治疗急性脑梗死临床疗效观察. 临床急诊杂志, 2003; 4(6): 26～27.
10.	龙明智, 王军, 谌蓉, 等. 中西医结合治疗急性缺血性脑梗塞的临床分析. 现代康复, 2000; 4(5): 682~683.
11.	李贤昌, 黄静波, 孙彦俊. 葛根素治疗脑梗死64例临床观察. 浙江中西医结合杂志, 2003; 13(9): 560.
12.	刘明龙. 葛根素氯化钠注射液辅助治疗急性脑梗死疗效观察. 现代中西医结合杂志, 2005; 14(7): 872~873。.
13.	邓娟, 周华东, 陈曼娥. 葛根素注射液对急性脑梗塞患者微循环保护机制的临床研究. 微循环学杂志, 2001; 11(1): 14~15.
14.	曹大力, 许宏伟, 胡景云, 等. 葛根素注射液治疗脑梗死的临床疗效. 湖南医学, 1999; 16(3): 191.
15.	张俭华. 葛根素治疗急性缺血性脑梗塞32例疗效观察. 浙江中西医结合杂志, 2002; 12(12): 731~732.
16.	贺卒英. 普乐林治疗老年人脑梗塞临床观察. 现代康复, 1998; 2(1): 44~45.
17.	应卫婵. 葛根素注射液治疗脑梗塞疗效观察. 浙江中西医结合杂志, 2002; 12(11): 690。.
18.	王碧云, 张梅丽, 谭燕, 等. 葛根素注射液对缺血性脑卒中患者的临床观察及其对血浆ET及HCY、OX-LDL的影响. 海南医学, 2005; 16(5): 9~10.
19.	马付坚. 葛根素对急性脑梗死纤溶及内皮功能治疗作用研究. 医学文选, 2001; 20(6): 794~795.
20.	扈友庄, 杨彬, 刘东彪. 葛根素对急性脑梗死患者血清SICAM-1, TNF-α水平的影响. 中国医师杂志, 2005; 7(8): 1135~1136.
21.	吴波, 刘鸣. 脑卒中临床试验疗效判定指标现状及趋势. 中华神经科杂志, 2002; 35(3): 177~179.
22.	International stroke trial collaborative group. The international stroke trial (IST): a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19 345 patients with acute ischaemic stroke. Lancet, 1997; 349(9065): 1569-1581.
23.	Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med, 1995; 333(24): 1581-1587.
24.	Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989; 20(10): 1407-1431.
25.	Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J, 1965; 14: 61- 65.
26.	Sulter G, Steen C, De Keyser J. Use of the Barthel index and modified Rankin scale in acute stroke scale in acute stroke trials. Stroke, 1999;30(8): 1538-1541.
27.	Liu M, Zhang SH. Intention to treat analysis in clinical trials. BMJ (Chinese edition), 2001; 4(4): 223-224.
28.	Wu ZS, Gao JF, Chen YS, et al. Observation of effect of pueraria injection and low molecular heparin on acute cerebral infarction. Journal of Brain and Neurology Disease, 2004; 12(1): 53-54, 58.
29.	Chao JX, Ye M. Clinical study of pueraria for acute ischemic stroke. Pharmacy of Guangdong, 2004; 14(3): 38-39.
30.	Song CJ, Li QR, Zhong XM, et al. Observation of effect of pueraria on cerebral infarction. Sichuan Medical Journal, 2005; 26(3): 306-307.
31.	. Shi Y, Ma HR. Observation of effect of pueraria on acute cerebral infarction. Yunnan Journal of Traditional Chinese Medicine and Materia Medica, 2005; 26(3): 7-8.
32.	Rong PH, Lin H, Cha PZ. 48 cases of pueraria and defibrase for acute cerebral infarction. Shaanxi Journal of Traditional Chinese Medicine, 2004; 25(2): 123-124.
33.	Wang J, Guang RL. Effect of pueraria and cerebrolysis on acute cerebral infarction. Practical Journal of Medicine and Pharmacy, 2002; 19(7): 502.
34.	Zhao LQ. Clinical observation on pueraria for acute ischemic stroke. Journal of Clinical Medicine in Practice, 2004; 8(2): 76.
35.	Wu XY. Observation on effect of pueraria and chuanxiongzine on acute cerebral infarction. Journal of Clinical Emergency, 2003; 4(6): 26 -27.
36.	Long MZ, Wang J, Shen R, et al. Observation on effect of gegen injection in treating patients of acute ischemic stroke. Modern Rehabilitation, 2000; 4(5): 682-683.
37.	Li CX, Huang JB, Shun YB. Clinical observation on pueraria injection for cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2003; 13(9): 560.
38.	Liu ML. Observation on effect of pueraria injection on acute cerebral infarction. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2005; 14(7): 72-873.
39.	Deng J, Zhou HD, Chen ME. Mechanism of Puerarin Induced Microcirculation Protection in Acute Cerebral Infarction. Chinese Journal of Microcirculation, 2001; 11(1): 14-15.
40.	Cao DL, Xu HW, Hu JY, et al. Observation of effect of pueraria injection on cerebral infarction. Hunan Medical Journal, 1999; 16(3): 191.
41.	Zhang JH. Observation of Therapeutic Efficacy in Treating Acute Cerebral Ischemia with Kankonein. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(12): 731-732.
42.	He ZY. Clinical observation of pueraria injection on cerebral infarction in the elder. Modern Rehabilitation, 1998; 2(1): 44- 45.
43.	Ying WC. Observation of effect of pueraria injection on cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(11): 690.
44.	Wang BY, Zhang ML, Tan Y, et al. Effects of puerarin injection treatment of cerebral ischemic stroke and its influence on plasma ET、HCY and OX-LDL. Hainan Medical Journal, 2005; 16(5): 9-10.
45.	Ma FJ. Effects of puerarin in treatment of acute cerebral infarction and its influence on fibrolysis system and endothelium function. Anthology of Medicine, 2001; 20(6): 794-795.
46.	Hu YZ, Yang B, Liu DB. Influence on plasma SICAM-1, TNF of puerarin for acute cerebral infarction. Journal of Chinese Physician, 2005; 7(8): 1135-1136.
47.	Wu B, Liu M. Trends of outcome measurement in stroke trials. Chinese Journal of Neurology, 2002; 35(3): 177-179.

1. 刘鸣, 张世洪. 临床试验中的意向处理分析. 英国医学杂志 (中文版), 2001; 4(4): 223-224.
2. 吴祖舜, 高俊凤, 陈玉山, 等. 普润 (葛根素) 葡萄糖注射液联合低分子肝素 (海普甯) 治疗急性脑梗死的疗效观察－附30例报告. 脑与神经疾病杂志, 2004; 12(1): 53～54,58.
3. 巢建新, 叶明. 葛根素治疗急性缺血性脑卒中的临床研究. 广东药学, 2004; 14(3): 38～39.
4. 宋春江, 李秋茹, 钟晓闵, 等. 葛根素治疗脑梗死40例疗效观察. 四川医学, 2005; 26(3): 306 ～307.
5. 石云, 马湖蕊. 葛根素治疗急性脑梗塞32例疗效观察. 云南中医中药杂志, 2005; 26(3): 7-8.
6. 荣培红, 林海, 查鹏洲. 葛根素联合降纤酶治疗急性脑梗塞48例. 陕西中医, 2004; 25(2): 123～124.
7. 王吉, 管仁莲. 葛根素与脑活素联合治疗急性脑梗塞的效果. 实用医药杂志, 2002; 19(7): 502.
8. 赵路清. 葛根素治疗急性脑梗死的临床观察. 实用临床医药杂志, 2004; 8(2): 76.
9. 吴新艳. 葛根素加川芎嗪治疗急性脑梗死临床疗效观察. 临床急诊杂志, 2003; 4(6): 26～27.
10. 龙明智, 王军, 谌蓉, 等. 中西医结合治疗急性缺血性脑梗塞的临床分析. 现代康复, 2000; 4(5): 682~683.
11. 李贤昌, 黄静波, 孙彦俊. 葛根素治疗脑梗死64例临床观察. 浙江中西医结合杂志, 2003; 13(9): 560.
12. 刘明龙. 葛根素氯化钠注射液辅助治疗急性脑梗死疗效观察. 现代中西医结合杂志, 2005; 14(7): 872~873。.
13. 邓娟, 周华东, 陈曼娥. 葛根素注射液对急性脑梗塞患者微循环保护机制的临床研究. 微循环学杂志, 2001; 11(1): 14~15.
14. 曹大力, 许宏伟, 胡景云, 等. 葛根素注射液治疗脑梗死的临床疗效. 湖南医学, 1999; 16(3): 191.
15. 张俭华. 葛根素治疗急性缺血性脑梗塞32例疗效观察. 浙江中西医结合杂志, 2002; 12(12): 731~732.
16. 贺卒英. 普乐林治疗老年人脑梗塞临床观察. 现代康复, 1998; 2(1): 44~45.
17. 应卫婵. 葛根素注射液治疗脑梗塞疗效观察. 浙江中西医结合杂志, 2002; 12(11): 690。.
18. 王碧云, 张梅丽, 谭燕, 等. 葛根素注射液对缺血性脑卒中患者的临床观察及其对血浆ET及HCY、OX-LDL的影响. 海南医学, 2005; 16(5): 9~10.
19. 马付坚. 葛根素对急性脑梗死纤溶及内皮功能治疗作用研究. 医学文选, 2001; 20(6): 794~795.
20. 扈友庄, 杨彬, 刘东彪. 葛根素对急性脑梗死患者血清SICAM-1, TNF-α水平的影响. 中国医师杂志, 2005; 7(8): 1135~1136.
21. 吴波, 刘鸣. 脑卒中临床试验疗效判定指标现状及趋势. 中华神经科杂志, 2002; 35(3): 177~179.
22. International stroke trial collaborative group. The international stroke trial (IST): a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19 345 patients with acute ischaemic stroke. Lancet, 1997; 349(9065): 1569-1581.
23. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med, 1995; 333(24): 1581-1587.
24. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989; 20(10): 1407-1431.
25. Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J, 1965; 14: 61- 65.
26. Sulter G, Steen C, De Keyser J. Use of the Barthel index and modified Rankin scale in acute stroke scale in acute stroke trials. Stroke, 1999;30(8): 1538-1541.
27. Liu M, Zhang SH. Intention to treat analysis in clinical trials. BMJ (Chinese edition), 2001; 4(4): 223-224.
28. Wu ZS, Gao JF, Chen YS, et al. Observation of effect of pueraria injection and low molecular heparin on acute cerebral infarction. Journal of Brain and Neurology Disease, 2004; 12(1): 53-54, 58.
29. Chao JX, Ye M. Clinical study of pueraria for acute ischemic stroke. Pharmacy of Guangdong, 2004; 14(3): 38-39.
30. Song CJ, Li QR, Zhong XM, et al. Observation of effect of pueraria on cerebral infarction. Sichuan Medical Journal, 2005; 26(3): 306-307.
31. . Shi Y, Ma HR. Observation of effect of pueraria on acute cerebral infarction. Yunnan Journal of Traditional Chinese Medicine and Materia Medica, 2005; 26(3): 7-8.
32. Rong PH, Lin H, Cha PZ. 48 cases of pueraria and defibrase for acute cerebral infarction. Shaanxi Journal of Traditional Chinese Medicine, 2004; 25(2): 123-124.
33. Wang J, Guang RL. Effect of pueraria and cerebrolysis on acute cerebral infarction. Practical Journal of Medicine and Pharmacy, 2002; 19(7): 502.
34. Zhao LQ. Clinical observation on pueraria for acute ischemic stroke. Journal of Clinical Medicine in Practice, 2004; 8(2): 76.
35. Wu XY. Observation on effect of pueraria and chuanxiongzine on acute cerebral infarction. Journal of Clinical Emergency, 2003; 4(6): 26 -27.
36. Long MZ, Wang J, Shen R, et al. Observation on effect of gegen injection in treating patients of acute ischemic stroke. Modern Rehabilitation, 2000; 4(5): 682-683.
37. Li CX, Huang JB, Shun YB. Clinical observation on pueraria injection for cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2003; 13(9): 560.
38. Liu ML. Observation on effect of pueraria injection on acute cerebral infarction. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2005; 14(7): 72-873.
39. Deng J, Zhou HD, Chen ME. Mechanism of Puerarin Induced Microcirculation Protection in Acute Cerebral Infarction. Chinese Journal of Microcirculation, 2001; 11(1): 14-15.
40. Cao DL, Xu HW, Hu JY, et al. Observation of effect of pueraria injection on cerebral infarction. Hunan Medical Journal, 1999; 16(3): 191.
41. Zhang JH. Observation of Therapeutic Efficacy in Treating Acute Cerebral Ischemia with Kankonein. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(12): 731-732.
42. He ZY. Clinical observation of pueraria injection on cerebral infarction in the elder. Modern Rehabilitation, 1998; 2(1): 44- 45.
43. Ying WC. Observation of effect of pueraria injection on cerebral infarction. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2002; 12(11): 690.
44. Wang BY, Zhang ML, Tan Y, et al. Effects of puerarin injection treatment of cerebral ischemic stroke and its influence on plasma ET、HCY and OX-LDL. Hainan Medical Journal, 2005; 16(5): 9-10.
45. Ma FJ. Effects of puerarin in treatment of acute cerebral infarction and its influence on fibrolysis system and endothelium function. Anthology of Medicine, 2001; 20(6): 794-795.
46. Hu YZ, Yang B, Liu DB. Influence on plasma SICAM-1, TNF of puerarin for acute cerebral infarction. Journal of Chinese Physician, 2005; 7(8): 1135-1136.
47. Wu B, Liu M. Trends of outcome measurement in stroke trials. Chinese Journal of Neurology, 2002; 35(3): 177-179.

Chinese Journal of Evidence-Based Medicine

Clinical Efficacy of Pueraria for Acute Cerebral Infarction

Abstract Full text Figures/Tables Video References Cited by

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