Clinical Evidence on Gliquidone for Diabetes Mellitus_Chinese Journal of Evidence-Based Medicine

Authors：

LI Jun ,  WU Hongmei

Department of Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China;

Corresponding author：

WU Hongmei, Email: drwhm@163.com

Keywords：

Gliquidone; Diabetes mellitus; Evidence-based medicine

Video：

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Objective 　To summarize the available clinical research evidence on gliquidone for treating diabetes mellitus.
Methods 　The clinical research on gliquidone for diabetes mellitus was systematically searched and appraised.
Result 　Six randomized controlled trials and eleven controlled clinical trials were identified. The methodological quality of most papers about gliquidone for diabetes mellitus was poor. Currently, clinically patient-related endpoints as outcome measures and health economic analyses are lacking in this field.
Conclusions 　Based on the available evidence, gliquidone appears specifically applicable to elderly diabetic patients with kidney diseases. More methodologically sound and patient-related endpoints and economic analyses based on clinical research are required.

Citation： LI Jun,WU Hongmei. Clinical Evidence on Gliquidone for Diabetes Mellitus. Chinese Journal of Evidence-Based Medicine, 2006, 06(9): 690-694. doi: Copy

1.	李幼平主编. 循证医学. 第1版. 北京: 高等教育出版社; 2003. 20～21.
2.	刘国良, 赵晓娟, 都建, 等. 糖适平治疗2型糖尿病的临床疗效观察. 辽宁实用糖尿病杂志, 2004; 12(3): 58～60.
3.	张子文, 吴长富, 许敏琦. 糖适平对2型糖尿病患者肾脏保护作用研究. 现代中西医结合杂志, 2004; 13(4): 488～489.
4.	王素如. 格列喹酮2种片剂治疗2型糖尿病的比较. 中国新药与临床杂志, 2000; 19(5): 417～418.
5.	李伟红, 周雅清. 糖适平治疗糖尿病肾功能不全10例疗效观察. 黑龙江医药科学, 2001; 24(3): 40.
6.	龚燕平, 李春霖, 田慧. 格列喹酮治疗老年人2型糖尿病疗效观察. 人民军医, 2004; 47(l1): 623～625.
7.	Nicolai H, Brickl R, Eschey H, et al. Duration of action and Pharmacokinetics of the oral antidiahetic drug gliquidone in patients with non-insulin-dependent (type2) diabetes mellitus. Arzneimittelforschung, 1997; 47(3): 247–252.
8.	Guyatt GH, Rennie D, Editors, The Evidence–Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. AMA Press, Chicago, 2002.
9.	Li YP, Chief editor. Evidence-Based Medicine. 1st eds. Beijing: Higher Education Press; 2003. 20–21.
10.	Ciccarone A, Cecchetti P, Orsini P, et al. Effects of gliquidone and glibenclamide on metabolic response and insulin receptor interaction in monocytes from patients with type 2 diabetes mellitus. Current Therapeutic Research, Clinical & Experimental, 1999; 60(6): 314–325.
11.	Harrower AD. Comparison of efficacy, secondary failure rate, and complications of sulfonylureas. J Diabetes Complications, 1994; 8(4): 201–203.
12.	Harrower AD. Efficacy of gliclazide in comparison with other sulphonylureas in the treatment of NIDDM. Diabetes research and clinical practice, 1991; 14(2): s65–67.
13.	Harrower AD. Comparison of diabetic control in type 2 (non-insulin dependent) diabetic patients treated with different sulphonylureas. Curr Med Res Opin, 1985; 9(10): 676–680.
14.	Nikkil K, Groop L. Glibenclamide and gliquidone in the treatment of non-insulin-dependent diabetes mellitus. Acta medica Scandinavica, 1982; 211(1-2): 13–17.
15.	Chou SC, Chen KW, Huang CC, et al. The effects of glurenorm on plasma glucose and lipids in patients with type 2 diabetes mellitus. Chang Gung Med J, 2000; 23(8): 480–484.
16.	Nitiyanant W, Sriussadaporn S, Deerochanawong C, et al. The efficacy and safety of gliquidone in Thai diabetics. J Med Assoc Thai, 1997; 80(12): 771–777.
17.	Degtiareva II, Lodianaia EV, Opanasiuk ND, et al. The use of the hypoglycemic preparation gliquidone in patients with digestive organ diseases combined with diabetes mellitus. Lik Sprava, 1995; (7-8): 84–87.
18.	Podrouzkova B, Krusova D. Combined therapy with insulin/gliquidone (Glurenorm) in type 2 diabetes after treatment failure using oral antidiabetic agents. Vnitr Lek, 1992; 38(10): 963–967.
19.	Bonora E, Moghetti P, Querena M, et al. Studies on the mechanism of action of sulphonylureas in type II diabetic subjects: gliquidone. J Endocrinol Invest, 1992; 15(1): 1-11.
20.	Kreze A, Vozar J, Razus P, et al. Multicenter study with gliquidone in type 2 diabetes mellitus. Vnitr Lek, 1991; 37(9–10): 761–767.
21.	Liu GL, Zhao XJ, Du J, et al. Clinical observation on the efficacy of glurenorm in the treatment of type 2 diabetes. Liaoning Journal of Practical Diabetology, 2004; 12(3): 58–60.
22.	Zhang ZW, Wu CF, Xu MQ. Research on the effect of glurenom in kidney protection of type 2 diabetes. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2004; 12(3): 58–60.
23.	Wang SR. Comparison of two tablet types of gliquidone in the treatment of type 2 diabetes. Chinese Journal of New Drugs and Clinical Remedies, 2000; 19(5): 417–418.
24.	Li WH, Zhou YQ. Observation on the efficacy of glurenom in the treatment of renal insufficiency caused by diabetes. Heilongjiang Medicine and Pharmacy, 2001; 24(3): 40.
25.	Gong YP, Li CL, Tian H. Observation on the efficacy of gliquidone in the treatment of type 2 diabetes in elderly patients. People’s Military Surgeon, 2004; 47(11): 623–625.

1. 李幼平主编. 循证医学. 第1版. 北京: 高等教育出版社; 2003. 20～21.
2. 刘国良, 赵晓娟, 都建, 等. 糖适平治疗2型糖尿病的临床疗效观察. 辽宁实用糖尿病杂志, 2004; 12(3): 58～60.
3. 张子文, 吴长富, 许敏琦. 糖适平对2型糖尿病患者肾脏保护作用研究. 现代中西医结合杂志, 2004; 13(4): 488～489.
4. 王素如. 格列喹酮2种片剂治疗2型糖尿病的比较. 中国新药与临床杂志, 2000; 19(5): 417～418.
5. 李伟红, 周雅清. 糖适平治疗糖尿病肾功能不全10例疗效观察. 黑龙江医药科学, 2001; 24(3): 40.
6. 龚燕平, 李春霖, 田慧. 格列喹酮治疗老年人2型糖尿病疗效观察. 人民军医, 2004; 47(l1): 623～625.
7. Nicolai H, Brickl R, Eschey H, et al. Duration of action and Pharmacokinetics of the oral antidiahetic drug gliquidone in patients with non-insulin-dependent (type2) diabetes mellitus. Arzneimittelforschung, 1997; 47(3): 247–252.
8. Guyatt GH, Rennie D, Editors, The Evidence–Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. AMA Press, Chicago, 2002.
9. Li YP, Chief editor. Evidence-Based Medicine. 1st eds. Beijing: Higher Education Press; 2003. 20–21.
10. Ciccarone A, Cecchetti P, Orsini P, et al. Effects of gliquidone and glibenclamide on metabolic response and insulin receptor interaction in monocytes from patients with type 2 diabetes mellitus. Current Therapeutic Research, Clinical & Experimental, 1999; 60(6): 314–325.
11. Harrower AD. Comparison of efficacy, secondary failure rate, and complications of sulfonylureas. J Diabetes Complications, 1994; 8(4): 201–203.
12. Harrower AD. Efficacy of gliclazide in comparison with other sulphonylureas in the treatment of NIDDM. Diabetes research and clinical practice, 1991; 14(2): s65–67.
13. Harrower AD. Comparison of diabetic control in type 2 (non-insulin dependent) diabetic patients treated with different sulphonylureas. Curr Med Res Opin, 1985; 9(10): 676–680.
14. Nikkil K, Groop L. Glibenclamide and gliquidone in the treatment of non-insulin-dependent diabetes mellitus. Acta medica Scandinavica, 1982; 211(1-2): 13–17.
15. Chou SC, Chen KW, Huang CC, et al. The effects of glurenorm on plasma glucose and lipids in patients with type 2 diabetes mellitus. Chang Gung Med J, 2000; 23(8): 480–484.
16. Nitiyanant W, Sriussadaporn S, Deerochanawong C, et al. The efficacy and safety of gliquidone in Thai diabetics. J Med Assoc Thai, 1997; 80(12): 771–777.
17. Degtiareva II, Lodianaia EV, Opanasiuk ND, et al. The use of the hypoglycemic preparation gliquidone in patients with digestive organ diseases combined with diabetes mellitus. Lik Sprava, 1995; (7-8): 84–87.
18. Podrouzkova B, Krusova D. Combined therapy with insulin/gliquidone (Glurenorm) in type 2 diabetes after treatment failure using oral antidiabetic agents. Vnitr Lek, 1992; 38(10): 963–967.
19. Bonora E, Moghetti P, Querena M, et al. Studies on the mechanism of action of sulphonylureas in type II diabetic subjects: gliquidone. J Endocrinol Invest, 1992; 15(1): 1-11.
20. Kreze A, Vozar J, Razus P, et al. Multicenter study with gliquidone in type 2 diabetes mellitus. Vnitr Lek, 1991; 37(9–10): 761–767.
21. Liu GL, Zhao XJ, Du J, et al. Clinical observation on the efficacy of glurenorm in the treatment of type 2 diabetes. Liaoning Journal of Practical Diabetology, 2004; 12(3): 58–60.
22. Zhang ZW, Wu CF, Xu MQ. Research on the effect of glurenom in kidney protection of type 2 diabetes. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2004; 12(3): 58–60.
23. Wang SR. Comparison of two tablet types of gliquidone in the treatment of type 2 diabetes. Chinese Journal of New Drugs and Clinical Remedies, 2000; 19(5): 417–418.
24. Li WH, Zhou YQ. Observation on the efficacy of glurenom in the treatment of renal insufficiency caused by diabetes. Heilongjiang Medicine and Pharmacy, 2001; 24(3): 40.
25. Gong YP, Li CL, Tian H. Observation on the efficacy of gliquidone in the treatment of type 2 diabetes in elderly patients. People’s Military Surgeon, 2004; 47(11): 623–625.

Chinese Journal of Evidence-Based Medicine

Clinical Evidence on Gliquidone for Diabetes Mellitus

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