- 1. Chinese Evidence-Based Medicine Centre/INCLEN CERTC, West China Hospital, Sichuan Univer-sity, Chengdu 610041, China2. West China Medical School, Sichuan University, Chengdu 610041, China;
Objective To assess the effectiveness and safety of reptilase in the treatment of bleeding due to internal diseases.
Methods The Cochrane Library, MEDLINE, VIP, and CNKI were searched. The quality of included studies was evaluated and meta-analysis was performed for the results of homogeneous studies.
Results Forty studies involving 2 879 participants related to a variety of internal diseases were included. All included studies were inadquate in reporting randomization, concealment of allocation and blinding. Meta-analysis based on included studies showed that reptilase could better alleviate bleeding compared with the control group in intrecranial encephalic hemorrhage (RD 0. 24, 95 % CI 0. 01 to 0.48), hypertension induced intrecranbd hemorrhage (RD -0.20, 95% CI -0. 38 to -0. 03), in hemostasis rate within 24 hours in hemoptysis (RD 0.41, 95% CI 0.17 to 0. 64), in upper alimentary tract hemorrhage ( RD 0.39, 95% CI 0.03 to 0. 76 ), in newborn upper alimentary tract hemorrhage (RD 0.32, 95% CI 0. 23 to 0.41 ). Only one case of hypersensitivity occured in reptilase group.
Conclusions Reptilase is an effective and safe hemostasia remedy for hemorrhage of internal diseases. Due to high risk of selection bias and detection bias of included studies, the evidence is not b enough to judge whether reptilase is better than other hemostatics. Our results suggest that further and larger-scale trials of the use of reptilase in the treatment of hemorrhages of internal diseases are needed.
Citation: WU Taixiang,XIE Linxia,ZHUO Qi. Reptilase in the Treatment of Hemorrhages: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2005, 05(10): 747-766. doi: Copy
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- 3. 卢洪萍,袁增权.甘露醇和巴曲酶(立芷雪)治疗新生儿颅内出血的临床探讨[J].儿科药学杂志,2002;8(4):25~26.
- 4. 李梅荣,王春生,蔡永敏.复方丹参注射液合血活素治疗高血压脑出血疗效观察[J]. 中成药,,2003;25(8):635~636.
- 5. 许春胜,苏长海,李爱云,范卫明,王洪新,陈金波,鹿树军,孙建英,杨忠,周晓生,郑麒,马贺.立芷雪对高血压性脑出血早期血肿继续扩大的干预研究[J]. 脑与神经疾病杂志,2003;11(3):181.
- 6. 黄立相,黎剑泉,杨晓红,吕龙,朱春龙.脑脊液置换疗法并鞘内注射立芷雪、地塞米松治疗蛛网膜下腔出血的临床研究[J]. 中华新医学,2004;5(8):689~690.
- 7. 郗崇利.立芷雪治疗支气管扩张咯血23例分析[J]. Shandong Medical Journal,2000;40(10):67~68.
- 8. 万耘.酚妥拉明与立芷雪联用治疗肺结核咯血27例疗效观察[J]. 厂矿医药卫生,2000;16(3):254~255.
- 9. 刘璋华.经纤支镜注入立芷雪治疗咯血临床观察[J]. 重庆医学,2004;33(7):117~118.
- 10. 陆普选,曹满瑞,蔡雄茂,孙燕芝,余卫业,杨根东,刘锦清,龚小龙,陈心春,郑广平.支气管动脉栓塞与结合局部应用立芷雪治疗肺结核咯血对照研究[J]. 中国医学影像技术,2003;19(8):1035~1036.
- 11. 贺仁忠,黄璐.立芷雪垂体后叶素、酚妥拉明治疗肺结核大咯血的疗效[J]. 现代医药卫生,2004;20(19):1990~1991.
- 12. 宋小意,许岩,徐齐峰.立芷雪和止血芳酸联合治疗老年肺结核并咯血疗效观察[J]. 医师进修杂志,2003;26(12):53~54.
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- 15. 赵虹.立芷雪预防早产儿肺出血[J]. 河南医药信息,2002;10(4):22~23.
- 16. 林名勤,蓝海燕.早期应用复方丹参注射液和立芷雪预防早产儿肺出血的临床观察[J]. 中国小儿血液,2002;7(2):89~90.
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