Clinical Trials of Traditional Chinese Medicine in China: Status and Evaluation_Chinese Journal of Evidence-Based Medicine

Authors：

LI TingQian , WANG Gang , WANG Lei , MAO Bing

Department of Integrated Trad itional Chinese & Western Medicine; West China Hospital; Sichuan University; Che ngdu 610041; China;

Corresponding author：

Keywords：

Traditional Chinese medicine; Evidence-based medicine; Clinical trial; St atus quo; Evaluation

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The modernization and internationalization of traditional Chinese medicine (TCM) are the key issues we must face up to. The development of TCM needs to depend on the breakthrough of methods and the innovation of ideology, and the international standardization of scientific research evaluation. The clinical evidence from randomized comtrolled trials (RCT) is valuable and reliable. It has shown that the proportion of RCT identified in TCM journals was less than 30%, and the score of RCT’s quality was less than 3 using Jadad scale. However, the number of systematic reviews on TCM is increasing rapidly after the evidence-based medicine (EBM) was introduced and practiced in China. Until 2004, 43 systematic reviews of TCM were published in China, and the quality of RCT included in those reviews was elevated. It has shown that the efficacy and safety of TCM indicated some advances in treatment of certain kind of diseases. It has been realized that RCT are important in TCM, and improving the quality of RCT is the key step for modernization and internationalization of TCM.

Citation： LI TingQian,WANG Gang,WANG Lei,MAO Bing. Clinical Trials of Traditional Chinese Medicine in China: Status and Evaluation. Chinese Journal of Evidence-Based Medicine, 2005, 05(6): 431-437. doi: Copy

1.	王覃, 吴泰相, 刘关键. 关于不稳定型心绞痛的中医药临床随机对照试验质量的评价[J]. 成都中医药大学学报, 2003; 26(2): 52～55.
2.	刘雪梅, 张鸣明, 李幼平, 李廷谦, 何林, 杜亮. 中西医结合治疗严重急性呼吸综合征的随机对照试验质量调查[J]. 中国循证医学杂志, 2003; 3(4) : 298～306.
3.	龙波, 陈玉成, 陈怀生, 曾智. 葛根素治疗冠心病心绞痛的临床研究文献评价[J]. 中国循证医学杂志, 2004; 4(5): 333～336.
4.	王蕾, 熊泽宇, 王刚, 李廷谦. 复方丹参滴丸治疗稳定型心绞痛随机对照试验的系统评价[J]. 中国中西医结合杂志, 2004; 24(6): 500～504.
5.	吴泰相, 刘关键, 张鸣明, 王覃, 倪娟, 魏家富, 周礼鲲, 段鑫, 陈小燕, 郑洁, 乔杰奇. 青蒿素类药物预防日本血吸虫感染效果及安全性的系统评价[J]. 中华医学杂志, 2003; 83(14): 1219～1224.
6.	吴泰相, 刘保延, 刘关键, 赵婷, 彭伟娜, 徐海蓉, 赵娜, 董碧蓉. 中西医结合治疗SARS疗效的系统评价[J]. 中国循证医学杂志. 2004, 4(4): 226～238.
7.	王蕾, 李廷谦, 张瑞明, 毛兵, 常静, 张颖. 达立通颗粒治疗痞满证(功能性消化不良)的随机对照双盲试验[J]. 中国循证医学杂志, 2004; 4(4): 239～266.
8.	黄继汉, 郑青山, 高蕊, 涂秀华, 徐凤芹, 孙瑞元. 牛黄降压片治疗原发性高血压病(肝火亢盛证)的临床等效性试验[J]. 中国循证医学杂志, 2004; 4(4): 249～254.
9.	张颖, 李廷谦, 王刚, 常静, 毛兵, 王蕾, 迟焕海, 万美华. 痰热清注射液治疗慢性阻塞性肺疾病急性加重期(痰热阻肺证)的随机对照试验[J]. 中国循证医学杂志, 2004; 4(5): 300～336.
10.	梁传余, 温蓓, 郑艳, 何刚, 范敏, 黎万荣, 唐嗣泉, 彭涛, 梁国庆, 王杰, 张玉萍. 鼻渊舒口服液改善慢性鼻窦炎/鼻息肉内窥镜手术预后的多中心随机对照试验[J]. 中国循证医学杂志, 2004; 4(6): 377～381, 416.
11.	况伟宏, 李进, 李静, 王雪, 黄明生, 王书臣, 李涛, 黄淑贞, 翁永振, 高成阁, 颜红. 九味虑平颗粒治疗广泛性焦虑障碍的随机双盲双模拟临床对照研究[J]. 中国循证医学杂志, 2004; 4(8): 523～527, 536.
12.	毛兵, 张瑞明, 王蕾, 常静, 李廷谦. 复方连蒲颗粒治疗感冒(风热证)的随机对照临床试验[J]. 中国循证医学杂志, 2004; 4(10): 677～684.
13.	王丽春, 雷秉钧, 刘丽, 刘聪, 张瑞明, 李廷谦. 九味柔肝颗粒治疗慢性乙型肝炎肝纤维化的随机对照双盲双模拟对照试验[J]. 中国循证医学杂志, 2004; 4(11): 778～782, 793.
14.	陈静, 刘世喜, 胡国华, 张学渊, 夏彦. 天麻注射液治疗眩晕的多中心单盲对照试验[J]. 中国循证医学杂志, 2004; 4(12): 864～870.
15.	李廷谦, 毛兵, 常静, 杨晓楠,王蕾, 张颖, 夏庆, 迟焕海, 巫刚, 熊泽宇, 陈光远, 黄宗文, 马建昕, 王刚, 赖珍玉. 中西医、中医核心杂志临床研究文献评价[J]. 华西医学, 2000; 15(3): 266～269.
16.	卫茂玲, 辜蕊, 张鸣明, 苏珊, 刘琴, 郑柳涛, 刘剑波, 杨曦, 宋黎. 11种地方性中医药期刊1995～2000年临床研究文献质量的初步分析[J]. 中国循证医学杂志, 2004; 4(6): 410～413.
17.	郭新峰, 赖世隆, 杨小波, 李先涛, 温泽淮, 梁伟雄.中医药治疗中风研究文献的质量评价[J]. 广州中医药大学学报, 2000; 17(1): 15～19.
18.	李宁, 吴滨, 杨华, 张永玲. 针灸治疗老年性痴呆临床随机对照试验方法学评价[J]. 华西医学, 2000; 15(1): 3～4.
19.	王玺坤, 崔学教, 邱云桥. 中医药治疗慢性前列腺炎临床研究文献质量的调查研究[J]. 中国中医药信息杂志, 2001; 8(1): 82～83.
20.	唐雪春, 罗翌, 赖世隆, 郭新峰, 宋苹. 对双黄连粉针剂治疗急性呼吸道感染研究文献的质量评价[J]. 广州中医药大学学报, 2002; 19(2): 149～153.
21.	孙洁. 中医药治疗阳萎文献质量分析[J]. 湖北中医学院学报, 2002; 4(3): 10～12.
22.	王澍欣, 洪文. 耳针治疗痤疮临床研究文献质量的调查[J]. 中国针灸, 2002; 22(12): 847～849.
23.	段鑫, 周礼鲲, 吴泰相, 刘关键. 中医药治疗冠心病的临床随机对照试验文献的质量分析[J]. 中国中西医结合杂志, 2003; 23(3): 164～167.
24.	林晓忠, 吴焕林, 刘泽银, 文旺秀. 原发性高血压中医药治疗性研究文献评价[J]. 华西医学, 2003; 18(4): 453～455.
25.	孙大志, 许玲, 姜林娣, 魏品康. 中医药治疗胃癌临床研究文献质量的调查评价[J]. 中国临床医学, 2003; 10(6): 833～835.
26.	王喜, 刘庆, 岳小强, 侯凤刚, 邓伟哲, 顾伟, 沈旭波. 对中医药治疗原发性肝癌临床研究的方法学评价[J]. 湖南中医学院学报, 2003; 23(4): 50～52.
27.	滕东海, 卢一平, 王莉, 李响, 魏强, 辛宇鹏, 刘孝东, 杨宇如. 中医药治疗慢性前列腺炎临床随机对照试验的方法学质量评价[J]. 华西医学, 2004; 19(1): 2～3.
28.	马斌. 中医药治疗老年痴呆-随机对照资料的质量分析和建议[J]. 辽宁中医杂志, 2004; 31(3): 203～204.
29.	李洁, 史美育, 施毅, 王琼芳,邸若虹, 倪伟. 中医药防治胆石症文献的方法学质量评价[J]. 上海中医药, 2004; 38(4): 17～18.
30.	周礼鲲, 段鑫, 安宁, 吴泰相, 刘关键. 冠心病心绞痛中医药研究文献的质量评价[J]. 中国循证医学杂志, 2004; 4(4): 258～266.
31.	陈弼沧, 吴秋英, 向成斌, 王丽英. 中医药治疗糖尿病肾病临床随机对照试验文献评价[J]. 福建中医药, 2004; 35(4): 5～6.
32.	徐珉, 司徒仪, 老鹰荣, 郭新峰, 温泽淮, 赖世隆. 中医药治疗子宫内膜异位症临床试验的文献评价[J]. 广州中医药大学学报, 2004; 21(5): 399～402.
33.	Li TQ, Mao B, Chang J, Yang XL, Wang L, Zhang Y, Xia Q, Chi HH, Wu G, Xiong ZY, Cheng GY, Huang ZW, Ma JX, Wang G, Lai ZY. An evaluation of clinical research literatures in core journals of traditional Chinese medicine integrated with western medicine or traditional Chinese medicine[J]. West China Medical Journal, 2000; 15(3): 266-269.
34.	Tang JL, Zhan SY, Ernst E. Review of randomised controlled trials of traditional Chinese medicine[J]. BMJ, 1999; 319(7203): 160-161.
35.	Wei ML, Gu R, Zhang MM, Su S, Liu Q, Zheng LT, Liu JB, Yang X, Song L. A brief study on the quality of clinical trials in 11 medical journals of traditional Chinese medicine from 1995 to 2000[J]. Chin J of EBM, 2004; 4(6): 410-413.
36.	Guo XF, Lai SL, Yang XB, Li XZ, Wen ZH, Liang WX. Quality analysis of literature of traditional Chinese medicine on clinical study of stroke[J]. Journal of Guangzhou University of Traditional Chinese medicine, 2000; 17(1): 15-19.
37.	Li N, Wu B, Yang H, Zhang YL. Methodological evaluation of randomized controlled trials for AD and VD treated by acupuncture and moxibustion from Chinese medical literatures[J]. West China Medical Journal, 2000; 15(1): 3-4.
38.	Wang XK, Chui XJ, Qiu YQ. Quality analysis of clinical study on the treatment of chronic prostatitis with traditional Chinese medicine[J]. Chinese Journal of information on traditional Chinese medicine, 2001; 8(1) : 82-83.
39.	Tang XC, Luo Y, Lai SL, Guo XF, Song P. Evaluation of studies on Shuang Huanglian injection for acute respiratory infections[J]. Journal of Guangzhou University of traditional Chinese medicine, 2002; 19(2): 149-153.
40.	Sun J. Quality analysis of clinical study on the treatment of Yangwei with traditional Chinese medicine[J]. Journal of Hubei College of Traditional Chinese Medicine, 2002; 4(3): 10-12.
41.	Wang SX, Hong W. Investigation on quality of literature of clinical studies of auricular acupuncture for treatment of acne[J]. Chinese Acupuncture & Moxibustion, 2002; 22(12): 847-849.
42.	Duan X, Zhou LK, Wu TX, Liu GJ. Quality analysis of literatures on clinical randomized controlled trial of coronary heat diseases treated with TCM [J]. Chin J of Integrated Traditional & Western Medicine, 2003; 23(3): 164-167.
43.	Lin XZ, Wu HL, Liu ZY, Wen WX. Evaluation on the articles of randomized controlled trials in primary hypertension treated[J]. West China Medical Journal, 2003; 18(4): 453-455.
44.	Sun DZ, Xu L, Jiang LD, Wei PK. Evaluation of the quality of clinical literatures of traditional Chinese Medicine for gastric carcinoma[J]. Clinical Medical Journal of China, 2003; 10(6): 833-835.
45.	Wang X, Liu Q, Yue XQ, Hou FG, Deng WZ, Gu W, Shen XB. Methodological evaluation of clinical study on traditional Chinese medicine therapies for primary liver carcinoma [J]. Journal of traditional Chinese medicine University of Hunan, 2003; 23(4): 50-52.
46.	Teng DH, Lu YP, Wang L, Li X, Wei Q, Xing YP, Liu XD, Yang YR. Methodological Quality assessment for randomized control trials on traditional Chinese medicine herbs in the treatment of chronic prostatitis[J]. West China Medical Journal, 2004; 19(1): 2-3.
47.	Ma B. Alzheimer’s disease with the treatment of traditional Chinese medicine: quality analysis and advice on randomized controlled trials[J]. Liaoning Journal of traditional Chinese medicine, 2004; 31(3): 203-204.
48.	Methodological quality of the literature involving the treatment of cholelithiasis by Chinese medicine[J]. Shanghai Journal of traditional Chinese medicine, 2004; 38(4): 17-18.
49.	Zhou LK, Duan X, An N, Wu TX, Liu GJ. Quality assessement of the studies of traditional Chinese medicine for coronary heart disease angina[J]. Chin J of EBM, 2004; 4(4): 258-266.
50.	Chen BC, Wu QY, Xiang CB, Wang LY. Quality analysis of randomize clinical trials on the treatment of diabetes mellitus with traditional Chinese medicine[J]. Fujian Journal of Traditional Chinese Medicine, 2004; 35(4): 5-6.
51.	Xu M, Shi TY, Lao YR, Guo XF, Wen ZH, Lai SL. Quality analysis of clinical trials on the treatment of endometriosis with Traditional Chinese Medicine[J]. Journal of Guangzhou University of traditional Chinese medicine, 2004; 21(5): 399-402.
52.	Wang T, Wu TX, Liu GJ. Quality analysis of randomized clinical trials on the treatment of unstable angina pectoris with traditional Chinese medicine[J]. Journal of Chengdu University of Traditional Chinese Medicine, 2003; 26(2): 52-55.
53.	Liu XM, Zhang MM, Li YP, Li TQ, He L, Du L. Quality of randomized controlled trials of traditional Chinese medicine integrated with western medicine for acute respiratory syndrome[J]. Chin J of EBM, 2003; 3(4): 298-306.
54.	Long B, Chen YC, Chen HS, Zheng Z. Quality assessment of clinical studies on puerarin for angina pectoris[J]. Chin J of EBM, 2004; 4(5): 333-336.
55.	Wang L, Xiong ZY, Wang G,Li TQ. Systematic assessment on randomized controlled trials for treatment of stable angina pectoris by compound selvia pellet[J]. Chin J of Integrated Traditional & Western Medicine, 2004; 24(6): 500-504.
56.	Wu TX, Liu GJ, Zhang MM, Wang T, Li J, Wei JF, Zhou LK, Duan X, Chen XY, Zheng J, Qiao JQ. Systematic review of benefits and harms of artemisinin type compounds for preventing schistosomiasis[J]. Natl Med J China, 2003; 83(14): 1219-1224.
57.	Wu TX. Liu BY, Liu GJ, Zhao Ting, Peng WN, Xu HR,Zhao Na, Dong BR. A systematic review of assessing the effect of integrated traditional Chinese medicine with western medicine for severe acute respiratory syndrome[J]. Chin J of EBM, 2004; 4(4): 226-238.
58.	Wang L, Li TQ, Zhang RM, Mao B, Chang J, Zhang Y. Double-blind randomized controlled trial of Dalitong granule in the treatment of Piman syndrome (Functional Dyspepsia) [J]. Chin J of EBM, 2004; 4(4): 239-266.
59.	Huang JH, Zheng QS, Gao R, Tu XH, Xu FQ, Sun RY. Clinical equivalence evaluation on the efficacy and safety of Niuhuangjiangya tablets and pills in the treatment of patients with primary hypertension[J]. Chin J of EBM, 2004; 4(4): 249-254.
60.	Zhang Y, Li TQ, Wang G, Chang J, Mao B, Wang L, Chi HH, Wan MH. Randomized controlled trial of Tanreqing injection in treatment of acute exacerbation of chronic obstructice pulmonary disease (syndrome of retention of Phlegm-heat in the lung) [J]. Chin J of EBM, 2004; 4(5): 300-336.
61.	Liang CY, Wen P, Zheng Y, He G, Fan M, Li WR, Tang SQ, Peng T, Liang GQ, Wang J, Zhang YP. Muti-centre randomized controlled trial of Bi Yuan Shu liquid on patients with chronic nasal sinusitis or nasal polyp after endosoopic sinus surgery[J]. Chin J of EBM, 2004; 4(6): 377-381, 416.
62.	Kuang WH, Li J, Li Jing, Wang X, Huang MS, Wang SC, Li T, Huang SZ, Weng YZ, Gao CG, Yan H. Randomized double-blind controlled trial on effectiveness and safety of Jiu Wei Lv Ping particle in the treatment of generalized anxiety disorder[J]. Chin J of EBM, 2004; 4(8): 523-527, 536.
63.	Mao B, Zhang RM, Wang L, Chang J, Li TQ. Randomized clinical trial of Lianpu granule in the treatment of common cold (Feng-Re Syndrome) [J]. Chin J of EBM, 2004; 4(10): 677-684.
64.	Wang LC, Lei BJ, Liu Li, Liu C, Zhang RM, Li TQ. Jiuweirougan granule in the treatment of chronic hepatitis with hepatic fibrosis: a double-blind randomized controlled trial[J]. Chin J of EBM, 2004; 4(11): 778-782, 793.
65.	Chen J, Liu SX, Hu GH, Zhang XY, Xia Y. Gastrodin injection in the treatment of Vertigo: a multi-center single-blind randomized controlled trial[J]. Chin J of EBM, 2004; 4(12): 864-870.

1. 王覃, 吴泰相, 刘关键. 关于不稳定型心绞痛的中医药临床随机对照试验质量的评价[J]. 成都中医药大学学报, 2003; 26(2): 52～55.
2. 刘雪梅, 张鸣明, 李幼平, 李廷谦, 何林, 杜亮. 中西医结合治疗严重急性呼吸综合征的随机对照试验质量调查[J]. 中国循证医学杂志, 2003; 3(4) : 298～306.
3. 龙波, 陈玉成, 陈怀生, 曾智. 葛根素治疗冠心病心绞痛的临床研究文献评价[J]. 中国循证医学杂志, 2004; 4(5): 333～336.
4. 王蕾, 熊泽宇, 王刚, 李廷谦. 复方丹参滴丸治疗稳定型心绞痛随机对照试验的系统评价[J]. 中国中西医结合杂志, 2004; 24(6): 500～504.
5. 吴泰相, 刘关键, 张鸣明, 王覃, 倪娟, 魏家富, 周礼鲲, 段鑫, 陈小燕, 郑洁, 乔杰奇. 青蒿素类药物预防日本血吸虫感染效果及安全性的系统评价[J]. 中华医学杂志, 2003; 83(14): 1219～1224.
6. 吴泰相, 刘保延, 刘关键, 赵婷, 彭伟娜, 徐海蓉, 赵娜, 董碧蓉. 中西医结合治疗SARS疗效的系统评价[J]. 中国循证医学杂志. 2004, 4(4): 226～238.
7. 王蕾, 李廷谦, 张瑞明, 毛兵, 常静, 张颖. 达立通颗粒治疗痞满证(功能性消化不良)的随机对照双盲试验[J]. 中国循证医学杂志, 2004; 4(4): 239～266.
8. 黄继汉, 郑青山, 高蕊, 涂秀华, 徐凤芹, 孙瑞元. 牛黄降压片治疗原发性高血压病(肝火亢盛证)的临床等效性试验[J]. 中国循证医学杂志, 2004; 4(4): 249～254.
9. 张颖, 李廷谦, 王刚, 常静, 毛兵, 王蕾, 迟焕海, 万美华. 痰热清注射液治疗慢性阻塞性肺疾病急性加重期(痰热阻肺证)的随机对照试验[J]. 中国循证医学杂志, 2004; 4(5): 300～336.
10. 梁传余, 温蓓, 郑艳, 何刚, 范敏, 黎万荣, 唐嗣泉, 彭涛, 梁国庆, 王杰, 张玉萍. 鼻渊舒口服液改善慢性鼻窦炎/鼻息肉内窥镜手术预后的多中心随机对照试验[J]. 中国循证医学杂志, 2004; 4(6): 377～381, 416.
11. 况伟宏, 李进, 李静, 王雪, 黄明生, 王书臣, 李涛, 黄淑贞, 翁永振, 高成阁, 颜红. 九味虑平颗粒治疗广泛性焦虑障碍的随机双盲双模拟临床对照研究[J]. 中国循证医学杂志, 2004; 4(8): 523～527, 536.
12. 毛兵, 张瑞明, 王蕾, 常静, 李廷谦. 复方连蒲颗粒治疗感冒(风热证)的随机对照临床试验[J]. 中国循证医学杂志, 2004; 4(10): 677～684.
13. 王丽春, 雷秉钧, 刘丽, 刘聪, 张瑞明, 李廷谦. 九味柔肝颗粒治疗慢性乙型肝炎肝纤维化的随机对照双盲双模拟对照试验[J]. 中国循证医学杂志, 2004; 4(11): 778～782, 793.
14. 陈静, 刘世喜, 胡国华, 张学渊, 夏彦. 天麻注射液治疗眩晕的多中心单盲对照试验[J]. 中国循证医学杂志, 2004; 4(12): 864～870.
15. 李廷谦, 毛兵, 常静, 杨晓楠,王蕾, 张颖, 夏庆, 迟焕海, 巫刚, 熊泽宇, 陈光远, 黄宗文, 马建昕, 王刚, 赖珍玉. 中西医、中医核心杂志临床研究文献评价[J]. 华西医学, 2000; 15(3): 266～269.
16. 卫茂玲, 辜蕊, 张鸣明, 苏珊, 刘琴, 郑柳涛, 刘剑波, 杨曦, 宋黎. 11种地方性中医药期刊1995～2000年临床研究文献质量的初步分析[J]. 中国循证医学杂志, 2004; 4(6): 410～413.
17. 郭新峰, 赖世隆, 杨小波, 李先涛, 温泽淮, 梁伟雄.中医药治疗中风研究文献的质量评价[J]. 广州中医药大学学报, 2000; 17(1): 15～19.
18. 李宁, 吴滨, 杨华, 张永玲. 针灸治疗老年性痴呆临床随机对照试验方法学评价[J]. 华西医学, 2000; 15(1): 3～4.
19. 王玺坤, 崔学教, 邱云桥. 中医药治疗慢性前列腺炎临床研究文献质量的调查研究[J]. 中国中医药信息杂志, 2001; 8(1): 82～83.
20. 唐雪春, 罗翌, 赖世隆, 郭新峰, 宋苹. 对双黄连粉针剂治疗急性呼吸道感染研究文献的质量评价[J]. 广州中医药大学学报, 2002; 19(2): 149～153.
21. 孙洁. 中医药治疗阳萎文献质量分析[J]. 湖北中医学院学报, 2002; 4(3): 10～12.
22. 王澍欣, 洪文. 耳针治疗痤疮临床研究文献质量的调查[J]. 中国针灸, 2002; 22(12): 847～849.
23. 段鑫, 周礼鲲, 吴泰相, 刘关键. 中医药治疗冠心病的临床随机对照试验文献的质量分析[J]. 中国中西医结合杂志, 2003; 23(3): 164～167.
24. 林晓忠, 吴焕林, 刘泽银, 文旺秀. 原发性高血压中医药治疗性研究文献评价[J]. 华西医学, 2003; 18(4): 453～455.
25. 孙大志, 许玲, 姜林娣, 魏品康. 中医药治疗胃癌临床研究文献质量的调查评价[J]. 中国临床医学, 2003; 10(6): 833～835.
26. 王喜, 刘庆, 岳小强, 侯凤刚, 邓伟哲, 顾伟, 沈旭波. 对中医药治疗原发性肝癌临床研究的方法学评价[J]. 湖南中医学院学报, 2003; 23(4): 50～52.
27. 滕东海, 卢一平, 王莉, 李响, 魏强, 辛宇鹏, 刘孝东, 杨宇如. 中医药治疗慢性前列腺炎临床随机对照试验的方法学质量评价[J]. 华西医学, 2004; 19(1): 2～3.
28. 马斌. 中医药治疗老年痴呆-随机对照资料的质量分析和建议[J]. 辽宁中医杂志, 2004; 31(3): 203～204.
29. 李洁, 史美育, 施毅, 王琼芳,邸若虹, 倪伟. 中医药防治胆石症文献的方法学质量评价[J]. 上海中医药, 2004; 38(4): 17～18.
30. 周礼鲲, 段鑫, 安宁, 吴泰相, 刘关键. 冠心病心绞痛中医药研究文献的质量评价[J]. 中国循证医学杂志, 2004; 4(4): 258～266.
31. 陈弼沧, 吴秋英, 向成斌, 王丽英. 中医药治疗糖尿病肾病临床随机对照试验文献评价[J]. 福建中医药, 2004; 35(4): 5～6.
32. 徐珉, 司徒仪, 老鹰荣, 郭新峰, 温泽淮, 赖世隆. 中医药治疗子宫内膜异位症临床试验的文献评价[J]. 广州中医药大学学报, 2004; 21(5): 399～402.
33. Li TQ, Mao B, Chang J, Yang XL, Wang L, Zhang Y, Xia Q, Chi HH, Wu G, Xiong ZY, Cheng GY, Huang ZW, Ma JX, Wang G, Lai ZY. An evaluation of clinical research literatures in core journals of traditional Chinese medicine integrated with western medicine or traditional Chinese medicine[J]. West China Medical Journal, 2000; 15(3): 266-269.
34. Tang JL, Zhan SY, Ernst E. Review of randomised controlled trials of traditional Chinese medicine[J]. BMJ, 1999; 319(7203): 160-161.
35. Wei ML, Gu R, Zhang MM, Su S, Liu Q, Zheng LT, Liu JB, Yang X, Song L. A brief study on the quality of clinical trials in 11 medical journals of traditional Chinese medicine from 1995 to 2000[J]. Chin J of EBM, 2004; 4(6): 410-413.
36. Guo XF, Lai SL, Yang XB, Li XZ, Wen ZH, Liang WX. Quality analysis of literature of traditional Chinese medicine on clinical study of stroke[J]. Journal of Guangzhou University of Traditional Chinese medicine, 2000; 17(1): 15-19.
37. Li N, Wu B, Yang H, Zhang YL. Methodological evaluation of randomized controlled trials for AD and VD treated by acupuncture and moxibustion from Chinese medical literatures[J]. West China Medical Journal, 2000; 15(1): 3-4.
38. Wang XK, Chui XJ, Qiu YQ. Quality analysis of clinical study on the treatment of chronic prostatitis with traditional Chinese medicine[J]. Chinese Journal of information on traditional Chinese medicine, 2001; 8(1) : 82-83.
39. Tang XC, Luo Y, Lai SL, Guo XF, Song P. Evaluation of studies on Shuang Huanglian injection for acute respiratory infections[J]. Journal of Guangzhou University of traditional Chinese medicine, 2002; 19(2): 149-153.
40. Sun J. Quality analysis of clinical study on the treatment of Yangwei with traditional Chinese medicine[J]. Journal of Hubei College of Traditional Chinese Medicine, 2002; 4(3): 10-12.
41. Wang SX, Hong W. Investigation on quality of literature of clinical studies of auricular acupuncture for treatment of acne[J]. Chinese Acupuncture & Moxibustion, 2002; 22(12): 847-849.
42. Duan X, Zhou LK, Wu TX, Liu GJ. Quality analysis of literatures on clinical randomized controlled trial of coronary heat diseases treated with TCM [J]. Chin J of Integrated Traditional & Western Medicine, 2003; 23(3): 164-167.
43. Lin XZ, Wu HL, Liu ZY, Wen WX. Evaluation on the articles of randomized controlled trials in primary hypertension treated[J]. West China Medical Journal, 2003; 18(4): 453-455.
44. Sun DZ, Xu L, Jiang LD, Wei PK. Evaluation of the quality of clinical literatures of traditional Chinese Medicine for gastric carcinoma[J]. Clinical Medical Journal of China, 2003; 10(6): 833-835.
45. Wang X, Liu Q, Yue XQ, Hou FG, Deng WZ, Gu W, Shen XB. Methodological evaluation of clinical study on traditional Chinese medicine therapies for primary liver carcinoma [J]. Journal of traditional Chinese medicine University of Hunan, 2003; 23(4): 50-52.
46. Teng DH, Lu YP, Wang L, Li X, Wei Q, Xing YP, Liu XD, Yang YR. Methodological Quality assessment for randomized control trials on traditional Chinese medicine herbs in the treatment of chronic prostatitis[J]. West China Medical Journal, 2004; 19(1): 2-3.
47. Ma B. Alzheimer’s disease with the treatment of traditional Chinese medicine: quality analysis and advice on randomized controlled trials[J]. Liaoning Journal of traditional Chinese medicine, 2004; 31(3): 203-204.
48. Methodological quality of the literature involving the treatment of cholelithiasis by Chinese medicine[J]. Shanghai Journal of traditional Chinese medicine, 2004; 38(4): 17-18.
49. Zhou LK, Duan X, An N, Wu TX, Liu GJ. Quality assessement of the studies of traditional Chinese medicine for coronary heart disease angina[J]. Chin J of EBM, 2004; 4(4): 258-266.
50. Chen BC, Wu QY, Xiang CB, Wang LY. Quality analysis of randomize clinical trials on the treatment of diabetes mellitus with traditional Chinese medicine[J]. Fujian Journal of Traditional Chinese Medicine, 2004; 35(4): 5-6.
51. Xu M, Shi TY, Lao YR, Guo XF, Wen ZH, Lai SL. Quality analysis of clinical trials on the treatment of endometriosis with Traditional Chinese Medicine[J]. Journal of Guangzhou University of traditional Chinese medicine, 2004; 21(5): 399-402.
52. Wang T, Wu TX, Liu GJ. Quality analysis of randomized clinical trials on the treatment of unstable angina pectoris with traditional Chinese medicine[J]. Journal of Chengdu University of Traditional Chinese Medicine, 2003; 26(2): 52-55.
53. Liu XM, Zhang MM, Li YP, Li TQ, He L, Du L. Quality of randomized controlled trials of traditional Chinese medicine integrated with western medicine for acute respiratory syndrome[J]. Chin J of EBM, 2003; 3(4): 298-306.
54. Long B, Chen YC, Chen HS, Zheng Z. Quality assessment of clinical studies on puerarin for angina pectoris[J]. Chin J of EBM, 2004; 4(5): 333-336.
55. Wang L, Xiong ZY, Wang G,Li TQ. Systematic assessment on randomized controlled trials for treatment of stable angina pectoris by compound selvia pellet[J]. Chin J of Integrated Traditional & Western Medicine, 2004; 24(6): 500-504.
56. Wu TX, Liu GJ, Zhang MM, Wang T, Li J, Wei JF, Zhou LK, Duan X, Chen XY, Zheng J, Qiao JQ. Systematic review of benefits and harms of artemisinin type compounds for preventing schistosomiasis[J]. Natl Med J China, 2003; 83(14): 1219-1224.
57. Wu TX. Liu BY, Liu GJ, Zhao Ting, Peng WN, Xu HR,Zhao Na, Dong BR. A systematic review of assessing the effect of integrated traditional Chinese medicine with western medicine for severe acute respiratory syndrome[J]. Chin J of EBM, 2004; 4(4): 226-238.
58. Wang L, Li TQ, Zhang RM, Mao B, Chang J, Zhang Y. Double-blind randomized controlled trial of Dalitong granule in the treatment of Piman syndrome (Functional Dyspepsia) [J]. Chin J of EBM, 2004; 4(4): 239-266.
59. Huang JH, Zheng QS, Gao R, Tu XH, Xu FQ, Sun RY. Clinical equivalence evaluation on the efficacy and safety of Niuhuangjiangya tablets and pills in the treatment of patients with primary hypertension[J]. Chin J of EBM, 2004; 4(4): 249-254.
60. Zhang Y, Li TQ, Wang G, Chang J, Mao B, Wang L, Chi HH, Wan MH. Randomized controlled trial of Tanreqing injection in treatment of acute exacerbation of chronic obstructice pulmonary disease (syndrome of retention of Phlegm-heat in the lung) [J]. Chin J of EBM, 2004; 4(5): 300-336.
61. Liang CY, Wen P, Zheng Y, He G, Fan M, Li WR, Tang SQ, Peng T, Liang GQ, Wang J, Zhang YP. Muti-centre randomized controlled trial of Bi Yuan Shu liquid on patients with chronic nasal sinusitis or nasal polyp after endosoopic sinus surgery[J]. Chin J of EBM, 2004; 4(6): 377-381, 416.
62. Kuang WH, Li J, Li Jing, Wang X, Huang MS, Wang SC, Li T, Huang SZ, Weng YZ, Gao CG, Yan H. Randomized double-blind controlled trial on effectiveness and safety of Jiu Wei Lv Ping particle in the treatment of generalized anxiety disorder[J]. Chin J of EBM, 2004; 4(8): 523-527, 536.
63. Mao B, Zhang RM, Wang L, Chang J, Li TQ. Randomized clinical trial of Lianpu granule in the treatment of common cold (Feng-Re Syndrome) [J]. Chin J of EBM, 2004; 4(10): 677-684.
64. Wang LC, Lei BJ, Liu Li, Liu C, Zhang RM, Li TQ. Jiuweirougan granule in the treatment of chronic hepatitis with hepatic fibrosis: a double-blind randomized controlled trial[J]. Chin J of EBM, 2004; 4(11): 778-782, 793.
65. Chen J, Liu SX, Hu GH, Zhang XY, Xia Y. Gastrodin injection in the treatment of Vertigo: a multi-center single-blind randomized controlled trial[J]. Chin J of EBM, 2004; 4(12): 864-870.

Chinese Journal of Evidence-Based Medicine

Clinical Trials of Traditional Chinese Medicine in China: Status and Evaluation

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