A Systematic Review of Assessing the Effect of Integrated Traditional Chinese Medicine with Western Medicine for Severe Acute Respiratory Syndrome_Chinese Journal of Evidence-Based Medicine

Authors：

WU Taixiang ¹ , LIU Baoyan ² , LIU Guanjian ¹ , ZHAO Ting ³ , PENG Weina ³ , XU Hairong ³ , ZHAO Na ¹ , DONG Birong ¹

1. Department of Clinical Edpimeology & Chinese Evidence-Based Medicine Centre; West China Hospital of Sichuan University（Chengdu 610041）; China 2. China Academy of Traditional Chinese Medicine（Beijing 100700） 3. Guang An Men Hospital; China Academy of Traditional Chinese Medicine（Beijing 100053）;

Corresponding author：

Keywords：

Severe acute respiratory syndrome; Integrated traditional Chinese medicine with western medicine; Systematic review

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To assess the effect of integrated traditional Chinese medicine with western medicine (ICWM) in the treatment of SARS.
Methods 　We searched MEDLINE, EMBASE, and Chinese BioMed Database ( CBM ) , and the Intemet performed handsearching in Chinese journals and reference lists. We included randomised controlled trials and prospective controlled studies of integrated Chinese medicine with western medicine versus western medicine alone in people with SARS. Three independent reviewers collected details of study population, interventions, and outcomes using a data extraction form. We conducted meta-analysis for similar data of studies.
Results 　Nine studies (n =812) were included, all with the possibility of containing serious bias. ICWM in the treatment of SARS was associated with the following reductions: case fatality [ OR 0.32, 95% CI (0.14,0.71 ) ] , fever clearance time [ WMD -1.17, 95% CI ( -1.83, -0.50 ) , symptom remission time [ WMD-1.47, 95% CI ( - 1.96, - 0. 98) ] and the number of inflammation absorption cases [ MD 1.63, 95% CI(0.95, 2.80 ) ], having no significant difference in symptom scores of convalescents [ WMD -1.25, 95% CI ( -2.71, 0.21 ) ], cumulative dose of corticosteroids [ WMD - 236.96, 95% CI ( - 490.64, 16.73) ] and inflammation absorption mean time [ WMD 0.63, 95% CI ( - 1.33, 2.59) ] .
Conclusions 　Due to the methodological limitations of the studies, the effect of ICWM for SARS is unclear. The apparent improvements in cases fatality, fever clearance time, syndromes remission time and numbers of inflammation absorption cases warrant further evaluation with high quality and large scale trials to be expected.

Citation： WU Taixiang,LIU Baoyan,LIU Guanjian,ZHAO Ting,PENG Weina,XU Hairong,ZHAO Na,DONG Birong. A Systematic Review of Assessing the Effect of Integrated Traditional Chinese Medicine with Western Medicine for Severe Acute Respiratory Syndrome. Chinese Journal of Evidence-Based Medicine, 2004, 04(4): 226-238. doi: Copy

1.	［31］Kjaergard LL, VillumsenJ, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses[J]. Annals of Internal Medicine, 2001;135(11 ) :982-989.
2.	［32］Egger M, Smith GD, Schneider M, Minder C. Bias in metaanalysis detected by a simple, graphical test[J]. BMJ, 1997;315 (7109) :629 -634.
3.	［33］Jiang ZY, Tong XD, Qi WS, Bian YJ, Song QQ, Li GW,Fu YL, Wang YH, Xiang XP, Wang RB, Chen YF, Liu BY, Xie YM. Efficacy of Chinese herbs in the treatment of SARS convalescents [ M ]. China Academy of Traditional Chinese Medicine. 2003. 64-81.
4.	姜在炀,唐旭东,齐文升,边永军,宋庆桥,李攻戊,付亚龙,王映辉,项晓培,王融冰,陈一凡,刘保延,谢雁鸣:中医药治疗SARS恢复期的临床疗效评价[M]中国中医研究院SARS研究文献汇编2003 64～81.
5.	［34］Li ZJ, Bao FH, Li Q, Li YP, Wang JD: Clinical study on treatment of severe acute respiratory syndrome with integrated traditional Chinese and western medicine [J ]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, 2003 ;10(4) :214-216.
6.	李志军,鲍凤和,李庆,王炳坤,李银平,王今达中西医结合治疗SARS临床研究[J]中国中西医结合急救杂志,2003;10(4):214～216.
7.	［35］Wang BE, Zhang SW, Ren AM. Traditional Chinese Medicine and western medicine in the treatment of SARS[ M ]. SARS Research, edited by China Academy of Traditional Chinese Medicine. 2003. 39 -41王宝恩,张淑文,任爱民中西医结合治疗SARS[M]中国中医研究院SARS研究文献汇编2003 39～41.
8.	［36］Wang RB, Liu JM, Wu YZ, Jiang YY, Wang XJ, Zhi PP,Sun FX. Effect assessment of traditional Chinese medicine integrated with western medicine in the treatment of SARS[M]. SARS Research, edited by China Academy of Traditional Chinese Medicine. 2003 ;31-34.
9.	王融冰,刘军民,吴云忠,江宇泳,王晓静,池频频,孙凤霞中西医结合治疗SARS疗效分析.中国中医研究院SARS研究文献汇编[M].2003 31～34.
10.	［37］Zhao CH, Li XH, Zhang K, Jin RH, Gou CY, Hu ZJ, Ye J, Yang Y, Guo XH, Liang LC, He JH, Li XM, Wu JS.Randomised control study of integrated traditional Chinese medicine and western medicine in treatment of 77 patients with severe acute respiratory syndrome [ J ]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, 2003; 10 ( 4 ): 197-200.
11.	赵春惠,李秀惠,张可,勾春燕,胡中杰,叶军,扬宇,郭新会,梁连春,胡建华,李雪梅,武聚山77例SARS患者中西医结合治疗随机对照研究[J]中国中西医结合急救杂志2003; 10(4) :197 ～200.
12.	［38］Zhang YP, Miao Q, Huang YZ, Yang ZX, Ji XH, Ji TJ,Xu FQ, Wang W, Hu NP, Guo Q, Xia CD, Zhang WJ,Feng DH, Zhang XL, Fan MR, Wang JG, Ma JH: A study of clinical effect of integrated traditional Chinese medicineand western medicine in the treatment of SARS. SARS Research,edited by China Academy of Traditional Chinese Medicine.2003. 62-66.
13.	张燕萍,苗青,黄尧洲,杨志旭,冀晓华,纪太军,徐凤芹,王伟,胡乃平,郭全,夏城东,张文江,冯德华,张旭丽,樊茂蓉,王建国,马建华中西医结合治疗SARS临床疗效评价研究[J]中国中医研究院SARS研究文献汇编2003.62～66.
14.	［39］Zhang RL, Jiao Q, Wang BG, Feng LM, Wang B, Wang HJ, Luo YN, Yan X, Shen HQ, Ma YM, Xiong Y, Chen WH, Ma D, Cheng C, Zhou W: Controlled clinical study on 49 patients of SARS treated by Integrated Chinese and westem medicine [ M ]. Chinese Journal of Integrated Traditional and Western Medicine, 2003; 23 ( 9 ): 654 - 657.
15.	张瑞麟,焦强,王保国,冯力民,王飙,王海箭,罗燕楠,剡雄,沈红强,马英明,熊云,陈卫衡,马达,程程,周卫中西医结合治疗49例SARS临床对照研究[J]中国中西医结合杂志2003;23(9):654～657.
16.	［40］Tong XL, Chen XG, Zhao D, Zhang ZY, Li AG, Duan J,Li T, Cui HJ, Mao JS, Li P, Liu P, Li CH, Hua CJ, Zhao TY, Zhang SN, Zheng M, Zhang YC, Li LJ, Cu XO,Wang WG, Li HC, Huang L, Hao YC, Du JX, Jia LQ,Zhao H, Zhang B, XY, Zhou SP, Shi XP, Lu J, Chang M,Qing WM, Wang YT. Effect assessment for Chinese traditional medicine integrated with western medicine in the treatment of 237 patients with SARS [ M ]. SARS Research,edited by China Academy of Traditional Chinese Medicine.2003. 13-20.
17.	仝小林,陈晓光,赵东,张志远,李爱国,段军,李涛,崔慧娟,毛建生,李平,刘鹏,李成辉,华传金,赵天豫,张纾难,郑敏,张远春,李丽玖,初笑鸥,王伟刚,李海聪,黄力,郝迎春,杜金行,贾立群,赵红,张斌,徐远,周水平,石效平,陆进,常明,秦文敏,王云亭中西医结合治疗SARS237例疗效分析[M]中国中医研究院SARS研究文献汇编2003.13～20.
18.	［41］Li XH, Zhang K, HuJH, Guo XH, Hu ZJ, Yang Y, Liang LJ. Clinical Observation on Effect of Treatment of Severe Acute Respiratory Syndrome (SARS) by Integrated Chinese and western medicine. Chinese Journal of Integrated Traditional and Western Medicine, 2003 ;23(7 ) :489-491.
19.	李秀辉,张可,胡建华,郭新会,胡中杰,扬宇,梁连春:中西医结合治疗SARS的临床疗效观察中国中西医结合杂志2003 ;23 (7) :489 ～ 491.
20.	［42］Wang RB, Liu JM, Jiang YY, Wu YZ, Wang XJ, Chi PP,Sun FX. Preliminary Study on Clinical Efficacy of Integrated Chinese and western medicine in Treating Severe Acute Respiratory Syndrome (SARS) [M]. Chinese Journal of Integrated Traditional and Western Medicine, 2003; 23 ( 7 ):492-493.
21.	王融冰,刘军民,江宇泳,吴云忠,王晓静,池频频,孙凤霞:中西医结合治疗SARS疗效初步分析中国中西医结合杂志.2003;23(7):492-493.
22.	［43］Hu YQ, Zhang RL, Zhang N, Jiao Q, Wang ZM, Qiu MY, Li FJ, Li Z, Wang YJ, Hou XB, Gao F, Zhou W.The advance of Chinese traditional medicine integrated with western medicine in the treatment of SARS [ M ]. SARS Research, edited by China Academy of Traditional Chinese Medicine. 2003. 132-137.
23.	胡荫奇,张瑞麟,张宁,焦强,王泽民,邱模炎,李方洁,李智,王义军,侯小兵,高峰,周卫对SARS的中医认识和中西医结合治疗的优势[M]中国中医研究院SARS研究文献汇编2003 132-137.
24.	［44］BianYJ, QiWS, ShongQQ, Li GS, Fu YL, TangXD,Jiang ZY, Wang YH. Evaluation on effect of integrative medical treatment on quality of life of rehabilitation stage in 85 patients with SARS [ J ]. Chinese Journal of Integrated Traditional and Western Medicine, 2003; 23 ( 9 ) :658-660.
25.	边永君,齐文生,宋庆桥,李攻戍,付亚龙,唐旭东,姜在炀,王映辉中西医结合治疗对85例SARS恢复期患者生存质量的影响[J].中国中西医结合杂志.2003;23(9):658-660.
26.	［1］WHO. Alert, verification and public health management of SARS in the post-outbreak period [ EB/OL ]. 2003 August 14. URL: http://www. who. int/csr/sars/postoutbreak/en/.
27.	［2］Guan Y, Zheng BJ, He YQ,. Liu XL, Zhuang ZX,Cheung CL, Luo SW, Li PH, Zhang LJ, Guan YJ, Butt KM, Wong KL, Chan KW, Lirm W, Shortridge KF, Yuen KY, Peiris JSM, Poon LLM. Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern na [ EB/OL]. Science, URL: http://www.sciencemag. org/cgi/content/ abstract/1087139 v1.
28.	［3］Zhong NS, Zeng QC. Our strategies for fighting severe acute respiratory syndrome ( SARS ) [ J ]. Am J Respir Crit Care Med. , 2003; 168(1 ) :7-9.
29.	［4］Hon KL, Leung CW, Cheng WT, Chan PK, Chu WC,Kwan YW, Li AM, Fong NC, Ng PC, Chiu MC, Li CK,Tam JS, Fok TF. Clinical presentations and outcome of severe acute respiratory syndrome in children[J]. Lancet, 2003; 361( 9370 ) :1701-1703.
30.	［5］Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM,Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC,Chung S, Sung JJ. A major outbreak of severe acute respiratory syndrome in Hong Kong [ J ]. N Engl J Med. ,2003; 348(20) :1986-1994.
31.	［6］Chen J, Xie YQ, Zhang HT, WanJW, Wang DT, LuZH,Wang QZ, Xue XH, Si WX, Luo YF, Qiu HM. Lung pathology of severe acute respiratory syndrome [ J ]. Acta Academiae Medicinae Sinicae, 2003; 25 (3) :360-362.
32.	［7］Franks TJ, Chong PY, Chui P, Galvin JR, Lourens RM,Reid AH, Selbs E, McEvoy CP, Hayden CD, Fukuoka J,Taubenberger JK, Travis WD. Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore[J]. Hum Patho,. 2003; 34(8) :743-748.
33.	［8］Lang Z, Zhang L, Zhang S, Meng X, Li J, Song C, Sun L,Zhou Y. Pathological study on severe acute respiratory syndrome [ J ]. Chin Med J ( Engl), 2003; 116 ( 7 ): 976-980.
34.	［9］Nicholls JM, Poon LL, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JS. Lung pathology of fatal severe acute respiratory syndrome [ J ].Lancet, 2003; 361 (9371):1773-1778.
35.	［10］Cui W, Fan Y, Wu W, Zhang F, Wang J Y, NiAP.Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome [ J ]. Clin Infect Dis,2003; 37 ( 6 ): 857-859.
36.	［11］He L, Ding YQ, Wang W, Zhang QL, Zhang JH, Geng J,Cai JJ. Expression of immune cells and their roles in the involved tissues of SARS patients [ J ]. Journal of First Military Medical University, 2003; 23 ( 8 ) :774-776, 780.
37.	［12］National Research Project For SARS Beijing Group. Dynamic changes of T-lymphocytes and immunoglobulins in patients with severe acute respiratory syndrome [ J ]. Chinese Medical Journal, 2003; 83(12) :1014-1017.
38.	［13］Yin CB, ZhangFC, TangXP, Chen WL, ChenYQ,Wang J, Jia WD. Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance [J ]. Chinese Journal of Tubergulosis and Respiratory Diseases, 2003; 26 ( 6 ) :343-346.
39.	［14］Li T, Qiu Z, HanY, Wang Z, Fan H, LuW, XieJ, Ma X, Wang A. R apid loss of both CD4+ and CD8 + T lymphocyte subsets during the acute phase of severe acute respiratory syndrome [ J ]. Chin Med J ( Engl ), 2003; 116(7) :985-987.
40.	［15］Li Z, Guo X, Hao W, Wu Y, JiY, Zhao Y, Liu F, Xie X. The relationship between serum interleukins and Tlymphocyte subsets in patients with severe acute respiratory syndrome[J]. Chin Med J ( Engl) , 2003; 116(7) :981-984.
41.	［16］Tang X, Yin C, Zhang F, Fu Y, Chen W, Chen Y, Wang J, Jia W, Xu A. Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance [ J ]. Chin Med J (Engl) ,2003; 116(6) :827-830.
42.	［17］WHO. Clinicalmanagementguidelines: Managementof Severe Acute Respiratory Syndrome ( SARS ) [ EB/OL ].URL: http ://www. who. int/csr/sars/management/en/.
43.	［18］So LK, Lau AC, Yam LY, Cheung TM, Poon E, Yung RW, Yuen KY: Development of a standard treatment protocol for severe acute respiratory syndrome. Lancet, 2003;361 (9369) :1615-1617.
44.	［19］Chinese Ministry of Health General Office. Announcement of issue revised diagnostic criteria of infectious atypical pneumonia(draft) and recommend treatment regime and discharge reference criteria[ EB/OL]. 2003 May 3; URL:http://www. moh. gov. cn/was40/detail.? record =6&channelid = 30749&searchword =% B4% AB% C8% BE%D0% D4% B7% C7% B5% E4% D0% CD% B7% CE% D1%D7 +AND +% D5% EF% B6% CF% B1% EA% D7% BC.
45.	［20］Tomlinson B, Cockram C. SARS: experience at Prince of Wales Hospital, Hong Kong[J ]. Lancet, 2003; 361 (9368):1486-7.
46.	［21］Joseph Sung. Preventing the spread of severe acute respiratory syndrome (SARS)[J]. Atlanta: Centers for Disease Control and Prevention, 2003 (broadcast). 2003 April 25. URL:http ://www. phppo. cdc. gov/PHTN/webcast/SARS/Sungsslides. pdf).
47.	［22］Oba Y. TheuseofcorticosteroidsinSARS[ J]. NEnglJ Med, 2003; 348(20) :2034-2035; author reply 2034-2035.
48.	［23］Gao Qiang. SARS Prevention and Control in China [ EB/OL]. Speak in 17 June 2003, Kuala Lumpur, WHO Global Conference on Severe Acute Respiratory Syndrome (SARS).URL: http ://www. who. int/csr/sars/conference/june_2003/eh/.
49.	［24］WHO. CaseD efinitionsforSurveillanceofSevereAcute Respiratory Syndrome (SARS) [ EB/OL ]. URL: http://www. who. int/csr/sars/casedefinition/en/.
50.	［25］CDC. Severe acute respiratory syndrome: Diagnosis /Evaluation[ EB/OL]. URL: http ://www. cdc. gov/ncidod/sars/diagnosis. htm.
51.	［26］InternationalConferenceonHarmonisationExpertWorking Group. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use[ A]. ICH harmonised tripartite guideline. Guideline for good clinical practice. CFR & ICH Guidelines. 1997; Vol. 1,Barnett Intemational/PAREXEL, PA 19063 -2043, USA.
52.	［27］Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials[J]. JAMA, 1995; 273(5):408-412.
53.	［28］Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? [ J ]Control Clin Trials, 1996; 17(1 ) :1-12.
54.	［29］Moher D, Pham B, Jones A, Cook DJ, Jadad A, Moher M,Tugwell P, Klassen TP. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in metaanalysis? [J] Lancet, 1998; 352(9128):609-613.
55.	［30］Juni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials [ J ].BMJ, 2001 ;323 (7303) :42 -46.

1. ［31］Kjaergard LL, VillumsenJ, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses[J]. Annals of Internal Medicine, 2001;135(11 ) :982-989.
2. ［32］Egger M, Smith GD, Schneider M, Minder C. Bias in metaanalysis detected by a simple, graphical test[J]. BMJ, 1997;315 (7109) :629 -634.
3. ［33］Jiang ZY, Tong XD, Qi WS, Bian YJ, Song QQ, Li GW,Fu YL, Wang YH, Xiang XP, Wang RB, Chen YF, Liu BY, Xie YM. Efficacy of Chinese herbs in the treatment of SARS convalescents [ M ]. China Academy of Traditional Chinese Medicine. 2003. 64-81.
4. 姜在炀,唐旭东,齐文升,边永军,宋庆桥,李攻戊,付亚龙,王映辉,项晓培,王融冰,陈一凡,刘保延,谢雁鸣:中医药治疗SARS恢复期的临床疗效评价[M]中国中医研究院SARS研究文献汇编2003 64～81.
5. ［34］Li ZJ, Bao FH, Li Q, Li YP, Wang JD: Clinical study on treatment of severe acute respiratory syndrome with integrated traditional Chinese and western medicine [J ]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, 2003 ;10(4) :214-216.
6. 李志军,鲍凤和,李庆,王炳坤,李银平,王今达中西医结合治疗SARS临床研究[J]中国中西医结合急救杂志,2003;10(4):214～216.
7. ［35］Wang BE, Zhang SW, Ren AM. Traditional Chinese Medicine and western medicine in the treatment of SARS[ M ]. SARS Research, edited by China Academy of Traditional Chinese Medicine. 2003. 39 -41王宝恩,张淑文,任爱民中西医结合治疗SARS[M]中国中医研究院SARS研究文献汇编2003 39～41.
8. ［36］Wang RB, Liu JM, Wu YZ, Jiang YY, Wang XJ, Zhi PP,Sun FX. Effect assessment of traditional Chinese medicine integrated with western medicine in the treatment of SARS[M]. SARS Research, edited by China Academy of Traditional Chinese Medicine. 2003 ;31-34.
9. 王融冰,刘军民,吴云忠,江宇泳,王晓静,池频频,孙凤霞中西医结合治疗SARS疗效分析.中国中医研究院SARS研究文献汇编[M].2003 31～34.
10. ［37］Zhao CH, Li XH, Zhang K, Jin RH, Gou CY, Hu ZJ, Ye J, Yang Y, Guo XH, Liang LC, He JH, Li XM, Wu JS.Randomised control study of integrated traditional Chinese medicine and western medicine in treatment of 77 patients with severe acute respiratory syndrome [ J ]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care, 2003; 10 ( 4 ): 197-200.
11. 赵春惠,李秀惠,张可,勾春燕,胡中杰,叶军,扬宇,郭新会,梁连春,胡建华,李雪梅,武聚山77例SARS患者中西医结合治疗随机对照研究[J]中国中西医结合急救杂志2003; 10(4) :197 ～200.
12. ［38］Zhang YP, Miao Q, Huang YZ, Yang ZX, Ji XH, Ji TJ,Xu FQ, Wang W, Hu NP, Guo Q, Xia CD, Zhang WJ,Feng DH, Zhang XL, Fan MR, Wang JG, Ma JH: A study of clinical effect of integrated traditional Chinese medicineand western medicine in the treatment of SARS. SARS Research,edited by China Academy of Traditional Chinese Medicine.2003. 62-66.
13. 张燕萍,苗青,黄尧洲,杨志旭,冀晓华,纪太军,徐凤芹,王伟,胡乃平,郭全,夏城东,张文江,冯德华,张旭丽,樊茂蓉,王建国,马建华中西医结合治疗SARS临床疗效评价研究[J]中国中医研究院SARS研究文献汇编2003.62～66.
14. ［39］Zhang RL, Jiao Q, Wang BG, Feng LM, Wang B, Wang HJ, Luo YN, Yan X, Shen HQ, Ma YM, Xiong Y, Chen WH, Ma D, Cheng C, Zhou W: Controlled clinical study on 49 patients of SARS treated by Integrated Chinese and westem medicine [ M ]. Chinese Journal of Integrated Traditional and Western Medicine, 2003; 23 ( 9 ): 654 - 657.
15. 张瑞麟,焦强,王保国,冯力民,王飙,王海箭,罗燕楠,剡雄,沈红强,马英明,熊云,陈卫衡,马达,程程,周卫中西医结合治疗49例SARS临床对照研究[J]中国中西医结合杂志2003;23(9):654～657.
16. ［40］Tong XL, Chen XG, Zhao D, Zhang ZY, Li AG, Duan J,Li T, Cui HJ, Mao JS, Li P, Liu P, Li CH, Hua CJ, Zhao TY, Zhang SN, Zheng M, Zhang YC, Li LJ, Cu XO,Wang WG, Li HC, Huang L, Hao YC, Du JX, Jia LQ,Zhao H, Zhang B, XY, Zhou SP, Shi XP, Lu J, Chang M,Qing WM, Wang YT. Effect assessment for Chinese traditional medicine integrated with western medicine in the treatment of 237 patients with SARS [ M ]. SARS Research,edited by China Academy of Traditional Chinese Medicine.2003. 13-20.
17. 仝小林,陈晓光,赵东,张志远,李爱国,段军,李涛,崔慧娟,毛建生,李平,刘鹏,李成辉,华传金,赵天豫,张纾难,郑敏,张远春,李丽玖,初笑鸥,王伟刚,李海聪,黄力,郝迎春,杜金行,贾立群,赵红,张斌,徐远,周水平,石效平,陆进,常明,秦文敏,王云亭中西医结合治疗SARS237例疗效分析[M]中国中医研究院SARS研究文献汇编2003.13～20.
18. ［41］Li XH, Zhang K, HuJH, Guo XH, Hu ZJ, Yang Y, Liang LJ. Clinical Observation on Effect of Treatment of Severe Acute Respiratory Syndrome (SARS) by Integrated Chinese and western medicine. Chinese Journal of Integrated Traditional and Western Medicine, 2003 ;23(7 ) :489-491.
19. 李秀辉,张可,胡建华,郭新会,胡中杰,扬宇,梁连春:中西医结合治疗SARS的临床疗效观察中国中西医结合杂志2003 ;23 (7) :489 ～ 491.
20. ［42］Wang RB, Liu JM, Jiang YY, Wu YZ, Wang XJ, Chi PP,Sun FX. Preliminary Study on Clinical Efficacy of Integrated Chinese and western medicine in Treating Severe Acute Respiratory Syndrome (SARS) [M]. Chinese Journal of Integrated Traditional and Western Medicine, 2003; 23 ( 7 ):492-493.
21. 王融冰,刘军民,江宇泳,吴云忠,王晓静,池频频,孙凤霞:中西医结合治疗SARS疗效初步分析中国中西医结合杂志.2003;23(7):492-493.
22. ［43］Hu YQ, Zhang RL, Zhang N, Jiao Q, Wang ZM, Qiu MY, Li FJ, Li Z, Wang YJ, Hou XB, Gao F, Zhou W.The advance of Chinese traditional medicine integrated with western medicine in the treatment of SARS [ M ]. SARS Research, edited by China Academy of Traditional Chinese Medicine. 2003. 132-137.
23. 胡荫奇,张瑞麟,张宁,焦强,王泽民,邱模炎,李方洁,李智,王义军,侯小兵,高峰,周卫对SARS的中医认识和中西医结合治疗的优势[M]中国中医研究院SARS研究文献汇编2003 132-137.
24. ［44］BianYJ, QiWS, ShongQQ, Li GS, Fu YL, TangXD,Jiang ZY, Wang YH. Evaluation on effect of integrative medical treatment on quality of life of rehabilitation stage in 85 patients with SARS [ J ]. Chinese Journal of Integrated Traditional and Western Medicine, 2003; 23 ( 9 ) :658-660.
25. 边永君,齐文生,宋庆桥,李攻戍,付亚龙,唐旭东,姜在炀,王映辉中西医结合治疗对85例SARS恢复期患者生存质量的影响[J].中国中西医结合杂志.2003;23(9):658-660.
26. ［1］WHO. Alert, verification and public health management of SARS in the post-outbreak period [ EB/OL ]. 2003 August 14. URL: http://www. who. int/csr/sars/postoutbreak/en/.
27. ［2］Guan Y, Zheng BJ, He YQ,. Liu XL, Zhuang ZX,Cheung CL, Luo SW, Li PH, Zhang LJ, Guan YJ, Butt KM, Wong KL, Chan KW, Lirm W, Shortridge KF, Yuen KY, Peiris JSM, Poon LLM. Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern na [ EB/OL]. Science, URL: http://www.sciencemag. org/cgi/content/ abstract/1087139 v1.
28. ［3］Zhong NS, Zeng QC. Our strategies for fighting severe acute respiratory syndrome ( SARS ) [ J ]. Am J Respir Crit Care Med. , 2003; 168(1 ) :7-9.
29. ［4］Hon KL, Leung CW, Cheng WT, Chan PK, Chu WC,Kwan YW, Li AM, Fong NC, Ng PC, Chiu MC, Li CK,Tam JS, Fok TF. Clinical presentations and outcome of severe acute respiratory syndrome in children[J]. Lancet, 2003; 361( 9370 ) :1701-1703.
30. ［5］Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM,Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC,Chung S, Sung JJ. A major outbreak of severe acute respiratory syndrome in Hong Kong [ J ]. N Engl J Med. ,2003; 348(20) :1986-1994.
31. ［6］Chen J, Xie YQ, Zhang HT, WanJW, Wang DT, LuZH,Wang QZ, Xue XH, Si WX, Luo YF, Qiu HM. Lung pathology of severe acute respiratory syndrome [ J ]. Acta Academiae Medicinae Sinicae, 2003; 25 (3) :360-362.
32. ［7］Franks TJ, Chong PY, Chui P, Galvin JR, Lourens RM,Reid AH, Selbs E, McEvoy CP, Hayden CD, Fukuoka J,Taubenberger JK, Travis WD. Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore[J]. Hum Patho,. 2003; 34(8) :743-748.
33. ［8］Lang Z, Zhang L, Zhang S, Meng X, Li J, Song C, Sun L,Zhou Y. Pathological study on severe acute respiratory syndrome [ J ]. Chin Med J ( Engl), 2003; 116 ( 7 ): 976-980.
34. ［9］Nicholls JM, Poon LL, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JS. Lung pathology of fatal severe acute respiratory syndrome [ J ].Lancet, 2003; 361 (9371):1773-1778.
35. ［10］Cui W, Fan Y, Wu W, Zhang F, Wang J Y, NiAP.Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome [ J ]. Clin Infect Dis,2003; 37 ( 6 ): 857-859.
36. ［11］He L, Ding YQ, Wang W, Zhang QL, Zhang JH, Geng J,Cai JJ. Expression of immune cells and their roles in the involved tissues of SARS patients [ J ]. Journal of First Military Medical University, 2003; 23 ( 8 ) :774-776, 780.
37. ［12］National Research Project For SARS Beijing Group. Dynamic changes of T-lymphocytes and immunoglobulins in patients with severe acute respiratory syndrome [ J ]. Chinese Medical Journal, 2003; 83(12) :1014-1017.
38. ［13］Yin CB, ZhangFC, TangXP, Chen WL, ChenYQ,Wang J, Jia WD. Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance [J ]. Chinese Journal of Tubergulosis and Respiratory Diseases, 2003; 26 ( 6 ) :343-346.
39. ［14］Li T, Qiu Z, HanY, Wang Z, Fan H, LuW, XieJ, Ma X, Wang A. R apid loss of both CD4+ and CD8 + T lymphocyte subsets during the acute phase of severe acute respiratory syndrome [ J ]. Chin Med J ( Engl ), 2003; 116(7) :985-987.
40. ［15］Li Z, Guo X, Hao W, Wu Y, JiY, Zhao Y, Liu F, Xie X. The relationship between serum interleukins and Tlymphocyte subsets in patients with severe acute respiratory syndrome[J]. Chin Med J ( Engl) , 2003; 116(7) :981-984.
41. ［16］Tang X, Yin C, Zhang F, Fu Y, Chen W, Chen Y, Wang J, Jia W, Xu A. Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance [ J ]. Chin Med J (Engl) ,2003; 116(6) :827-830.
42. ［17］WHO. Clinicalmanagementguidelines: Managementof Severe Acute Respiratory Syndrome ( SARS ) [ EB/OL ].URL: http ://www. who. int/csr/sars/management/en/.
43. ［18］So LK, Lau AC, Yam LY, Cheung TM, Poon E, Yung RW, Yuen KY: Development of a standard treatment protocol for severe acute respiratory syndrome. Lancet, 2003;361 (9369) :1615-1617.
44. ［19］Chinese Ministry of Health General Office. Announcement of issue revised diagnostic criteria of infectious atypical pneumonia(draft) and recommend treatment regime and discharge reference criteria[ EB/OL]. 2003 May 3; URL:http://www. moh. gov. cn/was40/detail.? record =6&channelid = 30749&searchword =% B4% AB% C8% BE%D0% D4% B7% C7% B5% E4% D0% CD% B7% CE% D1%D7 +AND +% D5% EF% B6% CF% B1% EA% D7% BC.
45. ［20］Tomlinson B, Cockram C. SARS: experience at Prince of Wales Hospital, Hong Kong[J ]. Lancet, 2003; 361 (9368):1486-7.
46. ［21］Joseph Sung. Preventing the spread of severe acute respiratory syndrome (SARS)[J]. Atlanta: Centers for Disease Control and Prevention, 2003 (broadcast). 2003 April 25. URL:http ://www. phppo. cdc. gov/PHTN/webcast/SARS/Sungsslides. pdf).
47. ［22］Oba Y. TheuseofcorticosteroidsinSARS[ J]. NEnglJ Med, 2003; 348(20) :2034-2035; author reply 2034-2035.
48. ［23］Gao Qiang. SARS Prevention and Control in China [ EB/OL]. Speak in 17 June 2003, Kuala Lumpur, WHO Global Conference on Severe Acute Respiratory Syndrome (SARS).URL: http ://www. who. int/csr/sars/conference/june_2003/eh/.
49. ［24］WHO. CaseD efinitionsforSurveillanceofSevereAcute Respiratory Syndrome (SARS) [ EB/OL ]. URL: http://www. who. int/csr/sars/casedefinition/en/.
50. ［25］CDC. Severe acute respiratory syndrome: Diagnosis /Evaluation[ EB/OL]. URL: http ://www. cdc. gov/ncidod/sars/diagnosis. htm.
51. ［26］InternationalConferenceonHarmonisationExpertWorking Group. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use[ A]. ICH harmonised tripartite guideline. Guideline for good clinical practice. CFR & ICH Guidelines. 1997; Vol. 1,Barnett Intemational/PAREXEL, PA 19063 -2043, USA.
52. ［27］Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials[J]. JAMA, 1995; 273(5):408-412.
53. ［28］Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? [ J ]Control Clin Trials, 1996; 17(1 ) :1-12.
54. ［29］Moher D, Pham B, Jones A, Cook DJ, Jadad A, Moher M,Tugwell P, Klassen TP. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in metaanalysis? [J] Lancet, 1998; 352(9128):609-613.
55. ［30］Juni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials [ J ].BMJ, 2001 ;323 (7303) :42 -46.

Chinese Journal of Evidence-Based Medicine

A Systematic Review of Assessing the Effect of Integrated Traditional Chinese Medicine with Western Medicine for Severe Acute Respiratory Syndrome

Abstract Full text Figures/Tables Video References Cited by

Format

Content