Cost Analysis in Clinical Trials_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Li ¹ , SUN Xin ¹ , HU Shanlian ² , LI Youping ¹

1. Chinese Cochrane Center; West China Hospital; Sichuan University; Chengdu 610041; China2. The Center for Research and Evaluation of Parmacoeconomics; Fudan University; Shanghai 200032;

Corresponding author：

Keywords：

Clinical trial; Cost analysis; Health economic evaluation

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Economic evaluation used alongside clinical trials has become a hot spot in the development of clinical studies. The definition and classification of the cost were introduced in this article. The ways to conduct cost analysis in clinical trials were introduced systematically, including the identification, collection and analysis of the data of costs, and the concern of the analysis.

Citation： WANG Li,SUN Xin,HU Shanlian,LI Youping. Cost Analysis in Clinical Trials. Chinese Journal of Evidence-Based Medicine, 2004, 04(4): 267-269. doi: Copy

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10.	［9］Clark RE, Teague GB, Ricketts SK, Bush PW, Keller AM,Zubkoff M, Drake RE. Measuring resource use in economic evaluations: determining the social costs of mental illness [J ]. Journal of Mental Health Adiministraion ,1994 ;21 ( 1 ) :32-41.
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12.	［11］Mullahy J , Manning W. Statistic issues in cost - effectiveness analysis[ A ]. In: Sloan FA. Valuing healthcare: costs benefits and effectiveness of pharmaceuticals and other medical technologies [ M ]. Cambridge: Cambridge University Press, 1995.
13.	［12］Bums T, Raftery J, Beadsmore A, McGuigan S, Dickson M.A controlled trial of home-based acute psychiatric services Ⅱ:Treatment patterns and costs[J]. British Journal of psychiatry,1993;163(15) :55-61.
14.	［13］Gray AM , Marshall M, Lockwood A, Morris J. Problems in conducting economic evaluations alongside clinical trials: lessons from a study of case management for people with mental disorders[J]. British Journal of psychiatry, 1997; 170 ( 40 ):47-52.
15.	［14］Her Majesty ’ s Treasury. Appraisal and evaluation in central government: treasury guidance [R ]. London: The Stationery Office, 1997.

1. ［1］He ZG , Chen J . Pharmaceutical economics and its role in controlling drug costs[J ]. Chinese Journal of Hospital Mangement, 1999; ( 5 ) :290-293.
2. 何志高,陈洁药物经济学及其在药品费用控制中的作用[J]中华医院管理杂志,1999;(5):290 293.
3. ［2］Drummond M. Economic analysis alongside controlled trials.Leeds: Department of Health, 1996.
4. ［3］Johnston K, Buxton MJ, Jones DR, Fitzpatric R. Assessing the costs of healthcare technologies in clinical trials [ J ]. Health Technology Assessment, 1999 ;3 ( 6 ): 1-76.
5. ［4］Johannesson M. A note on depreciation of the societal perspective in economic evaluation of healthcare[J]. Health policy, 1995;33(1): 59-66.
6. ［5］Cold MR, Siegel JE, Russell LB, Milton C. Cost-effectiveness in health and medicine[M]. New York: Oxford University Press ,1996.
7. ［6］Canadian Coordinating Office for Health Technology Assessment[R]. Guidelines for Economic Evaluation of Pharmaceuticals. Ottawa: CCOHTA. 1994.
8. ［7］Jomson B, Weinstein MC. Economic evaluation alongside multinational clinical trials: study considerations for GUSTO Iib[J]. International Journal of Technology Assessment of Health Care ,1997 ;13(1) :49-58.
9. ［8］Donaldson C, Shackley P. Economic evaluation[A]. In: Detels R, Holland WW, McEwen J, Omenn GS. Oxford textbook of public health[M]. 3rd ed. Oxford: Oxford University Press,1997.
10. ［9］Clark RE, Teague GB, Ricketts SK, Bush PW, Keller AM,Zubkoff M, Drake RE. Measuring resource use in economic evaluations: determining the social costs of mental illness [J ]. Journal of Mental Health Adiministraion ,1994 ;21 ( 1 ) :32-41.
11. ［10］Weissman JS, Levin K, Chasan-Taber S, Massagli MP, Seage GR 3rd, Scampini L. The validity of self-reported healthcare utilization by AIDS patients[J]. AIDS,1996;10(7):775-783.
12. ［11］Mullahy J , Manning W. Statistic issues in cost - effectiveness analysis[ A ]. In: Sloan FA. Valuing healthcare: costs benefits and effectiveness of pharmaceuticals and other medical technologies [ M ]. Cambridge: Cambridge University Press, 1995.
13. ［12］Bums T, Raftery J, Beadsmore A, McGuigan S, Dickson M.A controlled trial of home-based acute psychiatric services Ⅱ:Treatment patterns and costs[J]. British Journal of psychiatry,1993;163(15) :55-61.
14. ［13］Gray AM , Marshall M, Lockwood A, Morris J. Problems in conducting economic evaluations alongside clinical trials: lessons from a study of case management for people with mental disorders[J]. British Journal of psychiatry, 1997; 170 ( 40 ):47-52.
15. ［14］Her Majesty ’ s Treasury. Appraisal and evaluation in central government: treasury guidance [R ]. London: The Stationery Office, 1997.

Chinese Journal of Evidence-Based Medicine

Cost Analysis in Clinical Trials

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