Evidence-Based Therapy of Rheumatoid Arthritis_Chinese Journal of Evidence-Based Medicine

Authors：

YUE Jirong , GUO Jia , YANG Ming , DONG Birong

Department of Geriatrics; West China Hospital; Sichuan University; Chengdu 610041; China;

Corresponding author：

Keywords：

Rheumatoid arthritis; Evidence-based therapy

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Rheumatoid arthritis is a chronic inflammatory disorder. It is characterized by a chronic polyarthritis that primarily affects the peripheral joints and related periarticular tissues. To a patient with rheumatoid arthritis, we searched the evidence and indentified the best available therapy for him: ① Ibuprofen was used to relieve pain. ② Methopterin ivgtt qw and oral methopterin after the discharge for 12 months. ③ Oral omeprazole 20 mg/d to prevent peptic ulcear. ④ Administration with fish oil and physical exercises after discharge were recommended.

Citation： YUE Jirong,GUO Jia,YANG Ming,DONG Birong. Evidence-Based Therapy of Rheumatoid Arthritis. Chinese Journal of Evidence-Based Medicine, 2004, 04(5): 351-354. doi: Copy

1.	［1］Rostom A, Dube C, Wells G, Tugwell P, Welch V, Jolicoeur E,McGowan J. Prevention of chronic NSAID induced upper gastrointestinal toxicity[ M/CD]. In: The Cochrane Library,Issue 1, 2003. Oxford: Update Software.
2.	［2］Gotzsche PC, Johansen HK. Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis ( Cochrane Review) [ M/CD]. In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.
3.	［3］Van Den Ende CH, Vliet Vlieland TP, Munneke M, Hazes JM. Dynamic exercise therapy for treating rheumatoid arthritis (Cochrane Review) [M/CD]. In: The Cochrane Library,Issue 1, 2003. Oxford: Update Software.
4.	［4］Gotzsche PC. Meta-analysis of NSAIDs: contribution of drugs,doses, trial designs, and meta-analytic techniques[J]. Scand J Rheumatol, 1993; 22(6): 255-260.
5.	［5］Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ.Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs[J]. BMJ, 1998; 316(7128): 333 -338.
6.	［6］Suarez-Almazor ME, Belseck E, Wells G, Shea B, Tugwell P.Meta-analyses of placebo controlled trails of disease-modifying antirheumatic drugs (DMARDs)for the treatment of rheumatoid arthritis(RA) [J]. Arthritis Rheum, 1998; 41 ( 12 ): s153.
7.	［7］Maetzel A, Wong A, Strand V, Tngwell P, Wells G, Bombardier C. Meta-analysis of treatment teminarion rates among rheumatoid arthritis patients receiving disease-modifying antitheimatic drugs[J]. Rheumatology (Oxford), 2000; 39(9): 975 -981.
8.	［8］Volker D, Fitzgerald P, Major G, Garg M. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis [ J ]. J Rheumatol, 2000; 27 (10) :2 343-2 346.
9.	［9］Hawkey CJ, Karrasch JA, Szczepanski L, Walker DG, Barkun A, Swannell AJ, Yeomans ND. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group[J]. N Engl J Med, 1998; 338(11): 727-734.
10.	［10］Wolfe F, Hawley DJ, Cathey MA. Terminarion of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts [ J ]. J Rheumatol, 1990; 17(8): 994-1 002.
11.	［11］MacDonald TM, Morant SV, Robinson GC, Shield MJ,McGilchrist MM, Murray FE, McDevitt DG. Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study [J]. BMJ,1997; 315(7 119): 1 333 -1 337.
12.	［12］Henry D, Lim LL, Garcia Rodtiguez LA, Perez Gutthann S,Carson JL, Griffin M, Savage R, Logan R, Moride Y,Hawkey C, Hill S, Fries JT. Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis [J]. BMJ,1996; 312(7 046): 1563-1566.

1. ［1］Rostom A, Dube C, Wells G, Tugwell P, Welch V, Jolicoeur E,McGowan J. Prevention of chronic NSAID induced upper gastrointestinal toxicity[ M/CD]. In: The Cochrane Library,Issue 1, 2003. Oxford: Update Software.
2. ［2］Gotzsche PC, Johansen HK. Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis ( Cochrane Review) [ M/CD]. In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.
3. ［3］Van Den Ende CH, Vliet Vlieland TP, Munneke M, Hazes JM. Dynamic exercise therapy for treating rheumatoid arthritis (Cochrane Review) [M/CD]. In: The Cochrane Library,Issue 1, 2003. Oxford: Update Software.
4. ［4］Gotzsche PC. Meta-analysis of NSAIDs: contribution of drugs,doses, trial designs, and meta-analytic techniques[J]. Scand J Rheumatol, 1993; 22(6): 255-260.
5. ［5］Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ.Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs[J]. BMJ, 1998; 316(7128): 333 -338.
6. ［6］Suarez-Almazor ME, Belseck E, Wells G, Shea B, Tugwell P.Meta-analyses of placebo controlled trails of disease-modifying antirheumatic drugs (DMARDs)for the treatment of rheumatoid arthritis(RA) [J]. Arthritis Rheum, 1998; 41 ( 12 ): s153.
7. ［7］Maetzel A, Wong A, Strand V, Tngwell P, Wells G, Bombardier C. Meta-analysis of treatment teminarion rates among rheumatoid arthritis patients receiving disease-modifying antitheimatic drugs[J]. Rheumatology (Oxford), 2000; 39(9): 975 -981.
8. ［8］Volker D, Fitzgerald P, Major G, Garg M. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis [ J ]. J Rheumatol, 2000; 27 (10) :2 343-2 346.
9. ［9］Hawkey CJ, Karrasch JA, Szczepanski L, Walker DG, Barkun A, Swannell AJ, Yeomans ND. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group[J]. N Engl J Med, 1998; 338(11): 727-734.
10. ［10］Wolfe F, Hawley DJ, Cathey MA. Terminarion of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts [ J ]. J Rheumatol, 1990; 17(8): 994-1 002.
11. ［11］MacDonald TM, Morant SV, Robinson GC, Shield MJ,McGilchrist MM, Murray FE, McDevitt DG. Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study [J]. BMJ,1997; 315(7 119): 1 333 -1 337.
12. ［12］Henry D, Lim LL, Garcia Rodtiguez LA, Perez Gutthann S,Carson JL, Griffin M, Savage R, Logan R, Moride Y,Hawkey C, Hill S, Fries JT. Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis [J]. BMJ,1996; 312(7 046): 1563-1566.

Chinese Journal of Evidence-Based Medicine

Evidence-Based Therapy of Rheumatoid Arthritis

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