Randomized, Double Blind Controlled Trial of Trazodone versus Alprazolam in the Treatment of Generalized Anxiety Disorder_Chinese Journal of Evidence-Based Medicine

Authors：

JI Weidong , GUO Benyu , LI Ning , CHEN Zuoming

The Second Hospital of Xinxiang Medical College; Xinxiang 453002; China;

Corresponding author：

Keywords：

Trazodone; Alprazolam; Generalized anxiety disorder; Randomized controlled trial

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Objective 　To evaluate the therapeutic efficacy and safety of trazodone versus alprazolam for generalized anxiety disorder (GAD).
Methods 　After the third day of a three-day screening period, 60 patients with generalized anxiety disorder were randomly assigned to the trazodone group (30 patients, 50-150 mg/d), and alprazolam group (30 patients 1.2-4 mg/d) for 4 weeks. Patients and their doctors were blind. Data were analyzed by SPSS 10.0 and intention-to-treat analysis.
Results 　The total effective rate of trazodone was 77% (23/30), while alprazolam was 70% (21/30) (P gt;0.05) .No difference was seen for adverse events. None was lost to follow in the two groups.
Conclusions 　Trazodone appears to be as effective as alprazolam in treating generalized anxiety disorder. Adverse events may include confusion and loss of appetite, but patients are able to tolerate these.

Citation： JI Weidong,GUO Benyu,LI Ning,CHEN Zuoming. Randomized, Double Blind Controlled Trial of Trazodone versus Alprazolam in the Treatment of Generalized Anxiety Disorder. Chinese Journal of Evidence-Based Medicine, 2004, 04(8): 528-531. doi: Copy

1.	［1］Gath D. Generalized anxiety disorders[ A]. In:Gelder M, Mayou R, Cowen P, eds. Oxford Textbook of Psychiatry [M]. 3rd ed. New York: Oxford University Press, 1996: 162- 169.
2.	［2］Xu JM. Progress of the clinical application of Trazodone[J].Foreign Medical Sciences Section of Psychiatry, 2002, 29 (2):65 - 67.
3.	徐俊冕.曲唑酮临床应用研究的进展[J].国外医学精神病学分册,2002;29(2):65-67.
4.	［3］Tesar GE. High-potency BDZ for short-term management of panic disorder:the U.S. experience[J]. J Clin Psychiatry,1990 ;51:4-10.
5.	［4］Lydiard RB, Ballenger JC, R ickels K. A double-blind evaluation of the safety and efficacy of abecamil, alprazolam,and placebo in outpatients with generalized anxiety disorder [J]. J Clin Psychiatry,1997; 58(suppl 11 ) :11 -18.
6.	［5］Davidson JR. Use of benzodiazepines in social anxiety disorder,genernalized anxiety disorder, and posttraumatic stress disorder[J]. J Clin Psychiatry, 2004;65(suppl 5) :29 -33.
7.	［6］Hamilton M. Hamilton anxiety scale. In: Wang XD, Wang XL,Ma H, eds. Rating Scales for Mental Health [M]. Enlarged edition. Beijing: The Publishing Company of Chinese Mental Health Journal, 1999:223 - 226Hamilton M.
8.	汉密顿焦虑量表.见:汪向东,王希林,马弘,主编.心理卫生评定量表手册[M].增订版.北京:中国心理卫生杂志出版社;1999.p.223-226.
9.	［7］Lader MH, Bond AJ. Interaction of pharmacological and psychological treatments of anxiety[J]. Br J Psychiatry , 1998;173( Suppl 34) :165 - 168.
10.	［8］R ickels K, Downing R, Schweizer. Antidepressants for the treatment of generalized anxiety disorder:a placebo-controlled comparison of imipramine, trazodone, and diazepam [ J ]. Arch Gen Psychiatry, 1998 ;23 ( 50 ): 884 - 895.
11.	［9］Kapczinski F, Lima MS, Souza JS, Schmitt R. Antidepressants for generalized anxiety disorder (Cochrane Review )\[M/CD]. In: The Cochrane Library, Issue 2,2003. Oxford: Update Software.
12.	［10］Gamble PE, Peterson LG. Trazodone overdose four years of experience from voluntary reporters[J]. J Clinical Psychiatry,1986;47(1) :6.
13.	［11］Gould RA, Otto MW, Pollack MH, Yap L. Cognitive behavioural and pharmacological treatment of generalised anxiety disorder: a preliminary meta-analysis [ J ]. Behaviour Ther,1997 ;28(2): 285 -305.

1. ［1］Gath D. Generalized anxiety disorders[ A]. In:Gelder M, Mayou R, Cowen P, eds. Oxford Textbook of Psychiatry [M]. 3rd ed. New York: Oxford University Press, 1996: 162- 169.
2. ［2］Xu JM. Progress of the clinical application of Trazodone[J].Foreign Medical Sciences Section of Psychiatry, 2002, 29 (2):65 - 67.
3. 徐俊冕.曲唑酮临床应用研究的进展[J].国外医学精神病学分册,2002;29(2):65-67.
4. ［3］Tesar GE. High-potency BDZ for short-term management of panic disorder:the U.S. experience[J]. J Clin Psychiatry,1990 ;51:4-10.
5. ［4］Lydiard RB, Ballenger JC, R ickels K. A double-blind evaluation of the safety and efficacy of abecamil, alprazolam,and placebo in outpatients with generalized anxiety disorder [J]. J Clin Psychiatry,1997; 58(suppl 11 ) :11 -18.
6. ［5］Davidson JR. Use of benzodiazepines in social anxiety disorder,genernalized anxiety disorder, and posttraumatic stress disorder[J]. J Clin Psychiatry, 2004;65(suppl 5) :29 -33.
7. ［6］Hamilton M. Hamilton anxiety scale. In: Wang XD, Wang XL,Ma H, eds. Rating Scales for Mental Health [M]. Enlarged edition. Beijing: The Publishing Company of Chinese Mental Health Journal, 1999:223 - 226Hamilton M.
8. 汉密顿焦虑量表.见:汪向东,王希林,马弘,主编.心理卫生评定量表手册[M].增订版.北京:中国心理卫生杂志出版社;1999.p.223-226.
9. ［7］Lader MH, Bond AJ. Interaction of pharmacological and psychological treatments of anxiety[J]. Br J Psychiatry , 1998;173( Suppl 34) :165 - 168.
10. ［8］R ickels K, Downing R, Schweizer. Antidepressants for the treatment of generalized anxiety disorder:a placebo-controlled comparison of imipramine, trazodone, and diazepam [ J ]. Arch Gen Psychiatry, 1998 ;23 ( 50 ): 884 - 895.
11. ［9］Kapczinski F, Lima MS, Souza JS, Schmitt R. Antidepressants for generalized anxiety disorder (Cochrane Review )\[M/CD]. In: The Cochrane Library, Issue 2,2003. Oxford: Update Software.
12. ［10］Gamble PE, Peterson LG. Trazodone overdose four years of experience from voluntary reporters[J]. J Clinical Psychiatry,1986;47(1) :6.
13. ［11］Gould RA, Otto MW, Pollack MH, Yap L. Cognitive behavioural and pharmacological treatment of generalised anxiety disorder: a preliminary meta-analysis [ J ]. Behaviour Ther,1997 ;28(2): 285 -305.

Chinese Journal of Evidence-Based Medicine

Randomized, Double Blind Controlled Trial of Trazodone versus Alprazolam in the Treatment of Generalized Anxiety Disorder

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