Diagnosing Depression According to Changes in Rapid Eye Movements during Sleep_Chinese Journal of Evidence-Based Medicine

Authors：

SUN Xueli , ZHANG Wei , LI Tao , ZHANG Qi , LI Yan

Mental Health Center; West China Hospital; Sichuan University; Chengdu 610041; China;

Corresponding author：

Keywords：

Depression; Rapid eye movements sleep; Polysomnogram

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Objective 　To investigate the association between types of rapid eye movements during sleep and ICD-10 as a mothod for diagnosing depression.
Methods 　Depression was diagnosed according to ICD-10 and changes of 9 variables of REM sleep in 120 psychiatric outpatients and inpatients by calculating the Kappa values.
Results 　In 120 psychiatric patients, 52 depressive patients were diagnosed by using ICD-10, and 58 patients were diagnosed as depression according to decreased REM sleep latency and increased REM activity, REM intensity, REM density, and increasing amount of REM sleep. Kappa value was 0.73, P lt;0.05, which implied that these two diagnosing ways were significantly consistent.
Conclusions 　Measuremen of REM sleep variable should be investigated further as a supplementary method for diagnosing depression.

Citation： SUN Xueli,ZHANG Wei,LI Tao,ZHANG Qi,LI Yan. Diagnosing Depression According to Changes in Rapid Eye Movements during Sleep. Chinese Journal of Evidence-Based Medicine, 2004, 04(8): 553-555. doi: Copy

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1. 韩济生.主编.神经科学原理[M].第2版,北京:北京医科大学出版社,1999,903～915.
2. ［1］Sun XL, Liu XH, Zhang YH, Zhang Q, Li Y. A study on rapid eye movements sleep in the patients with depression and schizophrenia[J]. J of Nerv & Ment Dis, 1998; 24(6): 350 -352.
3. 孙学礼,刘协和,张远惠,张麒,李炎.抑郁症和精神分裂症的快眼动睡眠研究[J].中国神经精神疾病杂志,1998;24(6):349～351.
4. ［2］Sun XL. Polysomnograph in clinical psychiatric practice [J].Journal of Clinical Psychiatry, 1999; 9 ( 1 ): 45 - 47.
5. 孙学礼.多导睡眠图在精神医学中的应用[J].临床精神医学杂志,1999;9(1):45～47.
6. ［3］Sun XL, Liu XH, Zhang GZ, Zhang YH, Zhang Q. A study on sleep disorders on depressive, neurasthenic and normal subjects[J]. Chinese Journal of Neurology and Psychiatry, 1994;27(2): 101 -104.
7. 孙学礼,刘协和,张国柱,张远惠,张麒.抑郁症、神经衰弱和正常人的睡眠障碍研究[J].中华神经精神科杂志,1994;27(2):101～104.
8. ［4］Rechtschafen A, Kale A. A manual of standardized terminology techniques and scoring system for stages of human subjects[M].3rd ed. Los Angeles: Brain Information Service/Brain Institute of University of California, 1973; 1 - 12.
9. ［5］Han JS. Principle ofneuroscience[ M]. 2nd ed, Beijing: Beijing University of Medical Science Press, 1999; 903-915.

Chinese Journal of Evidence-Based Medicine

Diagnosing Depression According to Changes in Rapid Eye Movements during Sleep

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