WEI Yongsheng , YANG Yousong , LUO Yongjie , XIAO Jun , SUN Hongbin , GUO Fuqiang , DAI Hongyuan
  • Department of Neurology Sichuan Provincial Hospital; Chengdu 610031; China;
Naloxone; acute cerebral infarction; randomized controlled trial
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Objective 　To assess the effect of naloxone in treating the disease of acute cerebral infarction.
Methods 　Sixty patients of acute cerebral infarction were randomly divided into two groups. One group received routine therapy and the other routine therapy plus naloxone. Neuroprotective effect of naloxone were measured by using NIH stroke scale and Bathel-Index. Adverse effect of the drug was also observed.
Results 　There were 27 patients (90%) improved with clinical manifestations in experiment group, and 20 patients (67%) improved in control group. There is a significant difference between the two groups (P lt;0.05).There is no adverse reactions of naxloxone observed.
Conclusion 　Naloxone might protect the nervous cells and restore the function of the nervous system in patients with acute cerebral infraction.

Citation： WEI Yongsheng,YANG Yousong,LUO Yongjie,XIAO Jun,SUN Hongbin,GUO Fuqiang,DAI Hongyuan. Assessment of clinical effects of naloxone in treating patients with acute cerebral infarction. Chinese Journal of Evidence-Based Medicine, 2003, 03(3): 178-180. doi: Copy