Analysis of clinical studies on puerarin for ischemic stroke_Chinese Journal of Evidence-Based Medicine

Authors：

TAN Yan , LIU Ming

Department of Neurology; West China Hospital; Sichuan University; Chengdu 6/0041; China;

Corresponding author：

Keywords：

Puerarin; ischemic stroke; clinical studies

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Objective 　To investigate the current situation of clinical studies on puerarin for ischemic stroke and the reliability of these evidence.
Methods 　By electronic searching and handsearching, we collected all the published clinical study reports on puerarin for ischemic stroke and assessed all the included reports according to clinical epidemiologic standard.
Results 　35 RCTs, 22 non-randomized controlled trials and 17 case serials studies were included and analysed.
Conclusions 　Current quality of clinical studies of puerarin for ischemic stroke is not good enough to provide reliable evidence.

Citation： TAN Yan,LIU Ming. Analysis of clinical studies on puerarin for ischemic stroke. Chinese Journal of Evidence-Based Medicine, 2003, 03(3): 207-209. doi: Copy

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1. ［1］WHO.World health report 1999[R].Geneva WHO,1999.
2. ［2］European stroke initiave. Recommendation for stroke management[J]. Cerebrovascular Diseases 2000;10:335-351.
3. ［3］王家良.临床流行病学-临床科研设计,衡量与评价[M]第2版上海:上海科学技术出版社,2001:47-72.
4. ［4］The standards of reporting trials group. A proposal for structured reporting of randomized controlled trials[J].JAMA 1994;272:1926-1931.
5. ［5］Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials[J].JAMA 1996;276:637-639.
6. ［6］Schulz KF, Chalmers I, Hayes R J, et al. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials[J]. JAMA 1995;273:408-412.
7. ［7］Duncan PW, Jorgensen HS, Wade DT. Outcome measures in acute stroke trial [J].Stroke 2000;31:1429-1438.
8. ［8］刘鸣,张世洪新知识:临床试验中的意向处理分析[J].英国医学杂志中文版2001;4:223-224.

Chinese Journal of Evidence-Based Medicine

Analysis of clinical studies on puerarin for ischemic stroke

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