纳米级超声造影剂的技术进展_West China Medical Journal

Authors：

张美琴 ¹ , 周彩云 ² ,  罗红 ¹

Corresponding author：

罗红, Email: 2006zmqsjz@sina.com

Keywords：

纳米造影剂; 载药; 高分子聚合物; 脂质体

Video：

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Abstract Full text Figures/Tables Video References Cited by

纳米级超声造影剂是指直径＜1 000 nm的超声造影剂。与微米级微泡相比，纳米造影剂粒径较小，渗透能力极强，可以通过血管内皮间隙，进行病变部位血管外显影。同时因为纳米系统具有一定的靶向能力，将纳米级造影系统与临床治疗相结合可以在肿瘤治疗方面表现出其特定的靶向治疗优势。现就纳米级超声造影剂的特征、国内外制备方法及研究前景进行总结。

Citation： 张美琴,周彩云,罗红. 纳米级超声造影剂的技术进展. West China Medical Journal, 2012, 27(10): 1585-1587. doi: Copy

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25.	Marxer EE, Brüssler J, Becker A, et al. Development and characterization of new nanoscaled ultrasound active lipid dispersions as contrast agents[J]. Eur J Pharm Biopharm, 2011, 77 (3): 430-437.
26.	Wang D, Yang K, Gao YH, et al. Preparation and characterization of a nanoscale ultrasound contrast agent[J]. Clin Imaging, 2010, 34(4): 288-292.
27.	Becker A, Marxer E, Brüssler J, et al. Ultrasound active nanoscaled lipid formulations for thrombus lysis[J]. Eur J Pharm Biopharm, 2011, 77(3): 424-429.

1. 　Gramiak R, Shah PM, Kramer DH. Ultrasound cardiography: contrast studies in anatomy and function[J]. Radiology, 1969, 92(5): 939-948.
2. 　郑平. 超声对比造影的应用[J].中国分子心脏病学杂志, 2010, 10(4): 241-244.
3. 　Lencioni R, Piscaglia F, Bolondi L. Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma[J]. J Hepatol , 2008, 48(5): 848-857.
4. 　Görg C. The forgotten organ: contrast enhanced sonography of the spleen[J]. Eur J Radiol, 2007, 64(2): 189-201.
5. 　李凯,郑荣琴.输卵管的超声造影表现[J].中国超声诊断杂志, 2006,7(10): 745-747.
6. 　Gaur U, Sahoo SK, De TK, et al. Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system[J]. Int J Pharm, 2000, 202(1-2): 1-10.
7. 　Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis[J]. Adv Drug Deliv Rev, 2002, 54(5): 631-651.
8. 　Lanza GM, Winter PM, Caruthers SD, et al. Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions[J] . Angiogenesis, 2010, 13(2): 189-202.
9. 　杜永峰, 于铭, 闫烨. 微泡超声造影剂材料研究进展[J].功能材料, 2004, 35(增刊): 2473-2476.
10. 　曹银, 张洪波.超声造影剂制备方法[J],中国超声医学杂志, 2010, 26(9): 858-862.
11. 　Hadinoto K. Mechanical stability of hollow spherical nano-aggregates as ultrasound contrast agent[J]. Int J Pharm, 2009, 374(1-2): 153-161.
12. 　Wang Y, Li X, Zhou Y, et al. Preparation of nanobubbles for ultrasound imaging and intracelluar drug delivery[J]. Int J Pharm, 2010, 384(1-2): 148-53.
13. 　Forsberg F, Lathia JD, Merton DA, et al. of shell type on the in vivo backscatter from polymer-encapsulated microbubbles[J]. Ultrasound Med Biol, 2004, 30 (10): 1281-1287.
14. 　Sciallero C, Paradossi G, Trucco A. A preliminary in vitro assessment of polymer-shelled microbubbles in contrast-enhanced ultrasound imaging[J]. Ultrasonics, 2012, 52 (3): 456-464.
15. 　Néstor MM, Kei NP, Guadalupe NA, et al. Preparation and in vitro evaluation of poly(D, L-lactide-co-glycolide) air-filled nanocapsules as a contrast agent for ultrasound imaging[J]. Ultrasonics, 2011, 51(7): 839-845.
16. 　刘欣欣, 王衍戈，朱佩娟，等. 纳米级载药微泡的制备及其超声介导下的抑瘤研究[J]. 厦门大学学报(自然科学版), 2010, 49(6): 874-879.
17. 　Wheatley MA, Lewandowski J. Nano-sized ultrasound contrast agent:salting-out method[J]. Mol Imaging, 2010, 9(2): 96-107.
18. 　Rapoport N, Gao Z, Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy[J]. J Natl Cancer Inst, 2007, 99(14): 1095-1106.
19. 　Rapoport N, Kennedy AM, Shea JE, et al. Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging[J]. Mol Pharm, 2010, 7(1): 22-31.
20. 　Rapoport N, Nam KH, Gupta R, et al. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions[J]. J Control Release, 2011, 153(1): 4-15.
21. 　Mohan P, Rapoport N. Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intra cellular delivery[J]. Mol Pharm, 2010, 7(6): 1959-1973.
22. 　Díaz-López R, Tsapis N, Santin M, et al. The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent[J]. Biomaterials, 2010, 31(7): 1723-1731.
23. 　王平, 尹庭辉, 郑荣琴. 新型纳米微泡超声造影剂的制备及超声显像研究[J]. 中山大学学报（医学科学版）, 2011, 32(3): 327-330.
24. 　冯敏, 赵洪洋, 张丽, 等.纳米级脂质微泡的制备及其在动脉血栓检测中的应用[J].临床心血管病杂志, 2009, 25(12): 896-898.
25. 　Marxer EE, Brüssler J, Becker A, et al. Development and characterization of new nanoscaled ultrasound active lipid dispersions as contrast agents[J]. Eur J Pharm Biopharm, 2011, 77 (3): 430-437.
26. 　Wang D, Yang K, Gao YH, et al. Preparation and characterization of a nanoscale ultrasound contrast agent[J]. Clin Imaging, 2010, 34(4): 288-292.
27. 　Becker A, Marxer E, Brüssler J, et al. Ultrasound active nanoscaled lipid formulations for thrombus lysis[J]. Eur J Pharm Biopharm, 2011, 77(3): 424-429.

West China Medical Journal

纳米级超声造影剂的技术进展

Abstract Full text Figures/Tables Video References Cited by

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