内囊警示综合征研究进展_West China Medical Journal

Authors：

胡小辉 ¹ , 郑珍珍 ² ,  姚长江 ¹

Corresponding author：

姚长江, Email: smilewheeler@163.com

Keywords：

内囊警示综合征; 短暂缺血性发作; 桥脑警示综合征

Video：

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内囊警示综合征是一种反复刻板发作的脑短暂缺血性疾病，有时可类似癫痫发作。其综合征的病因可以是脑大血管病、脑小血管病、桥脑梗死、硬膜静脉窦血栓形成、间歇性血压下降等。综合征发展为永久性脑梗死的风险较高，并且常用于短暂缺血性发作的多种治疗方法（血液稀释、抗血小板聚集、溶栓治疗等），单独运用基本不能阻止发生永久性脑梗死的结局。联合疗法（抗血小板聚集、扩充血浆容量、溶栓治疗等联合）、颅内血管重塑术、抗癫痫、糖皮质激素、免疫抑制和药物性增加血压治疗可能对一些内囊警示综合征的患者有效。

Citation： 胡小辉,郑珍珍,姚长江. 内囊警示综合征研究进展. West China Medical Journal, 2012, 27(3): 459-462. doi: Copy

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2.	陈智才, 胡笑月, 周佳君, 等. 内囊警示综合征11例临床分析[J]. 中华神经科杂志, 2010, 43(12): 824-827.
3.	Muengtaweepongsa S, Singh NN, Cruz-Flores S. Pontine warning syndrome: case series and review of literature[J]. J Stroke Cerebrovasc Dis, 2010, 19(5): 353-356.
4.	Staaf G, Geijer B, Lindgren A, et al. Diffusion-weighted MRI findings in patients with capsular warning syndrome[J]. Cerebrovasc Dis, 2004, 17(1): 1-8.
5.	Farrar J, Donnan GA. Capsular warning syndrome preceding pontine infarction[J]. Stroke, 1993, 24(5): 762.
6.	Ferro JM, Falcao F, Melo TP, et al. Dural sinus thrombosis mimicking “capsular warning syndrome”[J]. J Neurol, 2000, 247(10): 802-803.
7.	Lee J, Albers GW, Marks MP, et al. Capsular warning syndrome caused by middle cerebral artery stenosis[J]. J Neurol Sci, 2010, 296(1-2): 115-120.
8.	Prabhakaran S, Krakauer JW. Multiple reversible episodes of subcortical ischemia following postcoital middle cerebral artery dissection[J]. Arch Neurol, 2006, 63(6): 891-893.
9.	Caporale CM, Notturno F, Caulo M, et al. Capsular warning syndrome mimicking a jacksonian sensory march[J]. J Neurol Sci, 2009, 285(1-2): 262-264.
10.	Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges[J]. Lancet Neurol, 2010, 9(7): 689-701.
11.	Tang CW, Wang PN, Lin KP, et al. Microscopic polyangiitis presenting with capsular warning syndrome and subsequent stroke[J]. J Neurol Sci, 2009, 277(1-2): 174-175.
12.	Ferro JM, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the international study on cerebral vein and dural sinus thrombosis (ISCVT)[J]. Stroke, 2004, 35(3): 664-670.
13.	Manzano-palomo S, Egido-Herrero JA, Saiz-Ayala A, et al. Transient ischemic attack: the only presenting syndrome of dural sinus thrombosis[J]. Neurologi, 2006, 21(3): 155-158.
14.	Wasay M, Bakshi R, Bobustuc G, et al. Cerebral venous thrombosis: analysis of a multicenter cohort from the United States[J]. J Stroke Cerebrovasc Dis, 2008, 17(2): 49-54.
15.	Lalive PH, Mayor I, Sztajzel R. The role of blood pressure in lacunar strokes preceded by TIAs[J]. Cerebrovasc Dis, 2003, 16(1): 88-90.
16.	Caplan L. Intracranial branch atheromatous disease: a neglected, understudied, and underused concept[J]. Neurol, 1989, 39(9): 1246-1250.
17.	山本康正. Branch atheromatous disease (BAD) の概念とその臨床意義[J]. 臨床神経, 2010, 50(11): 914-917.
18.	杨任民, 徐银. 分支动脉粥样硬化病附3例报告及文献复习[J]. 中国临床神经科学, 2010, 18(4): 396-400.
19.	武田英孝, 高木誠, 山本康正, 他. BADをどぅ治療するか[J]. 臨床神経, 2010, 50(11): 921-924.
20.	田口芳治, 高嵨修太郎, 温井孝昌, 他. Capsular warning syndrome を呈したbranch atheromatous disease の1例[J]. 臨床神経, 2010, 50(5): 320-324.
21.	Vivanco-Hidalgo RM, Rodriguez-Campello A, Ois A, et al. Thrombolysis in capsular warning syndrome[J]. Cerebrovasc Dis, 2008, 25(5): 508-510.
22.	Bruce NT, Neil WP, Zivin JA. Medico-legal aspects of using tissue plasminogen activator in acute ischemic stroke[J]. Cerebrovasc Dis and Stroke, 2011, 13(3): 233-239.
23.	Chernyshev OY, Martin-Schild S, Albright KC, et al. Safety of tPA in stroke mimics and neuroimaging-negative cerebral ischemia[J]. Neurol, 2010, 74(17): 1340-1345.
24.	Fahey CD, Alberts MJ, Bernstein RA. Oral clopidogrel load in aspirin-resistant capsular warning syndrome[J]. Neurocrit Care, 2005, 2(2): 183–184.
25.	斯晓燕, 赵永强. 阿司匹林抵抗研究进展[J]. 中国医学科学院学报, 2009, 31(5): 644-650.
26.	Ozben S, Ozben B, Tanrikulu AM, et al. Aspirin resistance in patients with acute ischemic stroke[J]. J Neurol, 2011, 258(11): 1979-1986.

1. 　Donnan GA, O’Malley HM, Quang L, et al. The capsular warning syndrome: pathogenesis and clinical features[J]. Neurol, 1993, 43(5): 957-962.
2. 　陈智才, 胡笑月, 周佳君, 等. 内囊警示综合征11例临床分析[J]. 中华神经科杂志, 2010, 43(12): 824-827.
3. 　Muengtaweepongsa S, Singh NN, Cruz-Flores S. Pontine warning syndrome: case series and review of literature[J]. J Stroke Cerebrovasc Dis, 2010, 19(5): 353-356.
4. 　Staaf G, Geijer B, Lindgren A, et al. Diffusion-weighted MRI findings in patients with capsular warning syndrome[J]. Cerebrovasc Dis, 2004, 17(1): 1-8.
5. 　Farrar J, Donnan GA. Capsular warning syndrome preceding pontine infarction[J]. Stroke, 1993, 24(5): 762.
6. 　Ferro JM, Falcao F, Melo TP, et al. Dural sinus thrombosis mimicking “capsular warning syndrome”[J]. J Neurol, 2000, 247(10): 802-803.
7. 　Lee J, Albers GW, Marks MP, et al. Capsular warning syndrome caused by middle cerebral artery stenosis[J]. J Neurol Sci, 2010, 296(1-2): 115-120.
8. 　Prabhakaran S, Krakauer JW. Multiple reversible episodes of subcortical ischemia following postcoital middle cerebral artery dissection[J]. Arch Neurol, 2006, 63(6): 891-893.
9. 　Caporale CM, Notturno F, Caulo M, et al. Capsular warning syndrome mimicking a jacksonian sensory march[J]. J Neurol Sci, 2009, 285(1-2): 262-264.
10. 　Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges[J]. Lancet Neurol, 2010, 9(7): 689-701.
11. 　Tang CW, Wang PN, Lin KP, et al. Microscopic polyangiitis presenting with capsular warning syndrome and subsequent stroke[J]. J Neurol Sci, 2009, 277(1-2): 174-175.
12. 　Ferro JM, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the international study on cerebral vein and dural sinus thrombosis (ISCVT)[J]. Stroke, 2004, 35(3): 664-670.
13. 　Manzano-palomo S, Egido-Herrero JA, Saiz-Ayala A, et al. Transient ischemic attack: the only presenting syndrome of dural sinus thrombosis[J]. Neurologi, 2006, 21(3): 155-158.
14. 　Wasay M, Bakshi R, Bobustuc G, et al. Cerebral venous thrombosis: analysis of a multicenter cohort from the United States[J]. J Stroke Cerebrovasc Dis, 2008, 17(2): 49-54.
15. 　Lalive PH, Mayor I, Sztajzel R. The role of blood pressure in lacunar strokes preceded by TIAs[J]. Cerebrovasc Dis, 2003, 16(1): 88-90.
16. 　Caplan L. Intracranial branch atheromatous disease: a neglected, understudied, and underused concept[J]. Neurol, 1989, 39(9): 1246-1250.
17. 　山本康正. Branch atheromatous disease (BAD) の概念とその臨床意義[J]. 臨床神経, 2010, 50(11): 914-917.
18. 　杨任民, 徐银. 分支动脉粥样硬化病附3例报告及文献复习[J]. 中国临床神经科学, 2010, 18(4): 396-400.
19. 　武田英孝, 高木誠, 山本康正, 他. BADをどぅ治療するか[J]. 臨床神経, 2010, 50(11): 921-924.
20. 　田口芳治, 高嵨修太郎, 温井孝昌, 他. Capsular warning syndrome を呈したbranch atheromatous disease の1例[J]. 臨床神経, 2010, 50(5): 320-324.
21. 　Vivanco-Hidalgo RM, Rodriguez-Campello A, Ois A, et al. Thrombolysis in capsular warning syndrome[J]. Cerebrovasc Dis, 2008, 25(5): 508-510.
22. 　Bruce NT, Neil WP, Zivin JA. Medico-legal aspects of using tissue plasminogen activator in acute ischemic stroke[J]. Cerebrovasc Dis and Stroke, 2011, 13(3): 233-239.
23. 　Chernyshev OY, Martin-Schild S, Albright KC, et al. Safety of tPA in stroke mimics and neuroimaging-negative cerebral ischemia[J]. Neurol, 2010, 74(17): 1340-1345.
24. 　Fahey CD, Alberts MJ, Bernstein RA. Oral clopidogrel load in aspirin-resistant capsular warning syndrome[J]. Neurocrit Care, 2005, 2(2): 183–184.
25. 　斯晓燕, 赵永强. 阿司匹林抵抗研究进展[J]. 中国医学科学院学报, 2009, 31(5): 644-650.
26. 　Ozben S, Ozben B, Tanrikulu AM, et al. Aspirin resistance in patients with acute ischemic stroke[J]. J Neurol, 2011, 258(11): 1979-1986.

West China Medical Journal

内囊警示综合征研究进展

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