Relation between Randomized Clinical Trials of Traditional Chinese Medicine and Local Burden of Disease in China_West China Medical Journal

Authors：

FAN Tao ¹ ,  ZHANG Yu ² , JIANG HongLi ¹ , MIN Jie ¹ , WANG Ke ¹ , ZHOU Wei ¹

1. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 2. Department of Intensive Care Medicine, The Integrated Medicine Hospital of Chengdu City, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHANG Yu, Email: Edward.fan@yeah.net

Keywords：

中医药; 随机对照试验; 疾病负担; 死亡率; 伤残调整寿命年

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　评估中医药临床研究是否与我国主要疾病负担相关。方法　首先从1999年－2004年出版的13种中医、中西医结合杂志中手工检索出随机对照试验（RCT），并提取出杂志名称、出版年限、治疗的疾病类别及样本含量等数据。然后采用死亡率和伤残调整寿命年（DALY）作为衡量标准，统计2002年我国疾病负担前30位病因的RCT数量，采用秩相关分析这些疾病负担与发表的中医药RCT及其受试者数量的关系。结果　最终确认7 422个RCT，约38%的RCT来自于3种国家级杂志。这些RCT覆盖了我国疾病负担中的主要病种，其中4 280个RCT（57.7%）研究前30位病因合并产生的42个病种，只有3个病种（7%）没有任何RCT研究。采用DALY得到的相关系数分别是0.108（P=0.569）、0.092（P=0.628），通过死亡率产生的相关系数分别是0.453（P=0.012）、0.536（P=0.002）。结论　中医药RCT与采用死亡率衡量的疾病负担明显相关，但采用DALY分析却未发现二者存在相关性。中医药临床研究可能更注重死亡率高的病种，一定程度上忽略了DALY衡量的疾病负担。

Citation： FAN Tao,ZHANG Yu,JIANG HongLi,MIN Jie,WANG Ke,ZHOU Wei. Relation between Randomized Clinical Trials of Traditional Chinese Medicine and Local Burden of Disease in China. West China Medical Journal, 2012, 27(4): 538-541. doi: Copy

1.	Gensus UT. World population profile: 1998[M]. Washington: US Government Printing Office, 1999: 31.
2.	Fraser DW. Overlooked opportunities for investing in health research and development[J]. Bull World Health Organ, 2000, 78(8): 1054-1061.
3.	Gross CP, Anderson GF, Powe NR. The relation between funding by the National Institutes of Health and the burden of disease[J]. N Engl J Med, 1999, 340(24): 1881-1887.
4.	Rochon PA, Mashari A, Cohen A, et al. Relation between randomized controlled trials published in leading general medical journals and the global burden of disease[J]. CMAJ, 2004, 170(11): 1673-1677.
5.	Perel P, Miranda JJ, Ortiz Z, et al. Relation between the global burden of disease and randomized clinical trials conducted in Latin America published in the five leading medical journals[J]. PLoS One, 2008, 3(2): e1696.
6.	Davey S. The 10/90 report on health research 2001-2002[M]. Geneva: Global Forum for Health Research, 2002.
7.	Sumathipala A, Siribaddana S, Patel V. Under-representation of developing countries in the research literature: ethical issues arising from a survey of five leading medical journals[J]. BMC Med Ethics, 2004, 5: E5.
8.	Miranda JJ, Zaman MJ. Exporting ’failure’: why research from rich countries may not benefit the developing world[J]. Rev Saude Publica, 2010, 44(1): 185-189.
9.	Stevens D, Siegel K, Smith R. Global interest in addressing non-communicable disease[J]. Lancet, 2007, 370(9603): 1901-1902.
10.	Wang G, Mao B, Xiong ZY, et al. The quality of reporting of randomized controlled trials of traditional Chinese medicine: a survey of 13 randomly selected journals from mainland China[J]. Clin Ther, 2007, 29(7): 1456-1467.
11.	毛兵, 王刚, 樊涛, 等. 中医药随机对照试验疾病谱的变化及趋势[J]. 中国中西医结合杂志, 2007, 27(5): 404-408.
12.	Isaakidis P, Swingler GH, Pienaar E, et al. Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research[J]. BMJ, 2002, 324(7339): 702.
13.	World Health Organization. Global Burden of Disease (GBD) 2002 estimates: incidence, prevalence, mortality, YLL, YLD and DALYs by sex, cause and region, estimates for 2002 as reported in the World Health Reports 2003 and 2004. Available from: http://www.who.int/ healthinfo/bodgbd2002/en/index.html.
14.	Tang JL. Research priorities in traditional Chinese medicine[J]. BMJ, 2006, 333(7564): 391-394.
15.	李廷谦, 毛兵, 常静, 等. 中西医、中医核心杂志临床研究文献评价[J]. 华西医学, 2000, 15(3): 266-269.
16.	Murray C, Lopez AD. The global burden of disease:a comprehensive assessment of mortality and disability from diseases,injuries,and risk factors in 1990 and projected to 2020[R]. Cambridge: Harvard School of Public Health, 1996: 43.
17.	王家良. 临床流行病学[M]. 第2版. 上海:上海科技出版社, 2011: 11-18.

1. 　Gensus UT. World population profile: 1998[M]. Washington: US Government Printing Office, 1999: 31.
2. 　Fraser DW. Overlooked opportunities for investing in health research and development[J]. Bull World Health Organ, 2000, 78(8): 1054-1061.
3. 　Gross CP, Anderson GF, Powe NR. The relation between funding by the National Institutes of Health and the burden of disease[J]. N Engl J Med, 1999, 340(24): 1881-1887.
4. 　Rochon PA, Mashari A, Cohen A, et al. Relation between randomized controlled trials published in leading general medical journals and the global burden of disease[J]. CMAJ, 2004, 170(11): 1673-1677.
5. 　Perel P, Miranda JJ, Ortiz Z, et al. Relation between the global burden of disease and randomized clinical trials conducted in Latin America published in the five leading medical journals[J]. PLoS One, 2008, 3(2): e1696.
6. 　Davey S. The 10/90 report on health research 2001-2002[M]. Geneva: Global Forum for Health Research, 2002.
7. 　Sumathipala A, Siribaddana S, Patel V. Under-representation of developing countries in the research literature: ethical issues arising from a survey of five leading medical journals[J]. BMC Med Ethics, 2004, 5: E5.
8. 　Miranda JJ, Zaman MJ. Exporting ’failure’: why research from rich countries may not benefit the developing world[J]. Rev Saude Publica, 2010, 44(1): 185-189.
9. 　Stevens D, Siegel K, Smith R. Global interest in addressing non-communicable disease[J]. Lancet, 2007, 370(9603): 1901-1902.
10. 　Wang G, Mao B, Xiong ZY, et al. The quality of reporting of randomized controlled trials of traditional Chinese medicine: a survey of 13 randomly selected journals from mainland China[J]. Clin Ther, 2007, 29(7): 1456-1467.
11. 　毛兵, 王刚, 樊涛, 等. 中医药随机对照试验疾病谱的变化及趋势[J]. 中国中西医结合杂志, 2007, 27(5): 404-408.
12. 　Isaakidis P, Swingler GH, Pienaar E, et al. Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research[J]. BMJ, 2002, 324(7339): 702.
13. 　World Health Organization. Global Burden of Disease (GBD) 2002 estimates: incidence, prevalence, mortality, YLL, YLD and DALYs by sex, cause and region, estimates for 2002 as reported in the World Health Reports 2003 and 2004. Available from: http://www.who.int/ healthinfo/bodgbd2002/en/index.html.
14. 　Tang JL. Research priorities in traditional Chinese medicine[J]. BMJ, 2006, 333(7564): 391-394.
15. 　李廷谦, 毛兵, 常静, 等. 中西医、中医核心杂志临床研究文献评价[J]. 华西医学, 2000, 15(3): 266-269.
16. 　Murray C, Lopez AD. The global burden of disease:a comprehensive assessment of mortality and disability from diseases,injuries,and risk factors in 1990 and projected to 2020[R]. Cambridge: Harvard School of Public Health, 1996: 43.
17. 　王家良. 临床流行病学[M]. 第2版. 上海:上海科技出版社, 2011: 11-18.

West China Medical Journal

Relation between Randomized Clinical Trials of Traditional Chinese Medicine and Local Burden of Disease in China

Abstract Full text Figures/Tables Video References Cited by

Format

Content