Clinical Analysis of Medulla Oblongata Tumor_West China Medical Journal

Authors：

HAO De , YANG Xiang ,  ZHANG Yuekang

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHANG Yuekang, Email: xichuan001@163.com

Keywords：

延髓; 肿瘤; 显微外科; 伽马刀

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目的　探讨延髓肿瘤的治疗策略，以达到最佳预后。方法　回顾分析2007年1月－2010年12月19例延髓肿瘤患者的临床资料，其中18例经外科手术治疗和病理证实，1例通过影像学确诊。结果　12例血管网状细胞瘤中，11例手术全切，1例手术次全切；2例室管膜瘤均手术全切；2例海绵状血管瘤分别手术全切及伽马刀治疗；3例胶质瘤均手术部分切除。18例手术治疗患者术后神经功能障碍明显好转者13例，无明显变化者3例，2例因术后严重并发症死亡；1例伽马刀治疗患者症状好转。术后随访6～48个月，平均24个月。11例恢复工作，4例生活可自理，2例因肿瘤复发死亡。结论　术前通过MRI检查、术中神经电生理监测及熟练的显微外科技术是外科治疗优势，伽马刀治疗延髓较小肿瘤有着损伤小的优点，因此制定合理的治疗策略有利于提高患者生存质量。

Citation： HAO De,YANG Xiang,ZHANG Yuekang. Clinical Analysis of Medulla Oblongata Tumor. West China Medical Journal, 2012, 27(6): 885-888. doi: Copy

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1. 　Dan SH, James Z, Donlin M. Surgical resection of intrinsic brain steml lesions: an overview[J]. Neurosurgery, 1990, 27(5): 789-798.
2. 　Chang UK, ChoeWJ, Chung SK, et al. Surgical outcome and prognostic factors of spinal intramedullary ependymomas in adults[J]. J Neurooncol, 2002, 57(2): 133-139.
3. 　周良辅, 杜固宏, 毛颖, 等. 脑干血管母细胞瘤的诊断和治疗[J]. 中华神经外科杂志, 2004, 20(2): 127-131.
4. 　Wang C, Zhang J, Liu A, et al. Surgical management of medullary hemangioblastoma. Report of 47 cases [J]. Surg Neurol, 2001, 56(4): 218-227.
5. 　Weil RJ, Lonser RR, DeVroom HL, et al. Surgical man-agement of brainstem hemangioblastomas in patients withvon Hippel-Lindau disease [J]. J Neurosurg, 2003, 98(1): 95-105.
6. 　Parker F, Aghakhani N, Ducati LG, et al. Results of micro-surgical treatment of medulla oblongata and spinal cordhemangioblastomas: a comparison of two distinct clinicalpatient groups [J]. J Neurooncol, 2009, 93(1): 133-137.
7. 　王恩敏, 张南, 王滨江. 伽玛刀治疗血管母细胞瘤临床分析[J]. 中华外科杂志, 2003, 41(9): 516-520.
8. 　Kohno K, Matsul S, Nishizaki A, et al. Successful total removal of intramedullary hemangiohlastoma from the medulla oblongata[J]. Surg Neurol, 1993, 39(2): 25-30.

West China Medical Journal

Clinical Analysis of Medulla Oblongata Tumor

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