Research on Efficiency of H2 Receptor Antagonists and Proton Pump Inhibitors in Alleviating Gastric Mucosal Lesions Caused by Acute Alcohol Intoxication_West China Medical Journal

Authors：

ZHOU Luming ¹ , LAI Shichao ² , HU Hai ² ,  CAO Yu ²

1. Emergency Department, Chengdu 7th People’s Hospital, Chengdu, Sichuan 610021, P. R. China; 2. Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

CAO Yu, Email: 38565592@qq.com

Keywords：

H2受体拮抗剂; 质子泵抑制剂; 急性乙醇中毒急性胃黏膜损伤; 时效性

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目的　探讨H2受体拮抗剂和质子泵抑制剂（PPI）缓解急性胃黏膜损伤的时效性研究。方法　对2008年1月－2010年1月在急诊科就诊的98例急性乙醇中毒后胃黏膜损伤患者，随机分为对照组50例，治疗组48例。常规给予休息、保暖，补液，维持水、电解质、酸碱平衡，维持循环功能等治疗基础上，对照组给予H2受体拮抗剂治疗，治疗组给予PPI治疗。通过观察急性胃黏膜损伤患者上消化道症状及体征，记录不同饮酒及饮酒量，并根据患者就诊时间及不同饮酒组治疗后上消化道症状完全缓解时间进行比较。结果　治疗组上消化道症状缓解所需时间与对照组比较差异有统计学意义（P＜0.001），不同饮酒组上消化道症状缓解时间上差异有统计学意义（P=0.000）。结论　PPI在缓解急性乙醇中毒所致胃黏膜损伤的时效上更明显，具有临床价值。

Citation： ZHOU Luming,LAI Shichao,HU Hai,CAO Yu. Research on Efficiency of H2 Receptor Antagonists and Proton Pump Inhibitors in Alleviating Gastric Mucosal Lesions Caused by Acute Alcohol Intoxication. West China Medical Journal, 2012, 27(9): 1319-1321. doi: Copy

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7.	张宏亮, 徐杨, 范晓. 不同病因导致的应激性胃黏膜损伤中环氧化酶-2的改变[J]. 华西医学, 2010, 25(5): 833-836.
8.	何绍珍, 任建林. 乙醇对胃黏膜作用机制的研究进展[J]. 世界华人消化杂志, 2005, 13(21): 2591-2596.
9.	吴燕燕, 郭勇, 邹妤婕. 泮托拉唑治疗急性酒精中毒后胃黏膜损伤的疗效观察[J]. 中国药房, 2011, 22(28): 2650-2652.
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1. 　Knoll MR, Kolbel CB, Teyssen S, et al. Action of pureethanol and some alcoholic beverages on the gastric mucosain healthy humans: a descriptive endoscopic study[J]. Endoscopy, 1998, 30(3): 293-301.
2. 　Yakabi K, Nakamura T. Acute gastroduodenal mucosal lesion[J]. Nihon Rinsho, 1998, 56(9): 2336-2342.
3. 　陈曼彤, 崔西玉, 邱小蕾, 等. 上消化道出血病因及发病趋势分析[J]. 实用临床医学, 2005, 6(10): 15-17.
4. 　拓楠, 余宏宇. 酒精致胃黏膜损伤的研究进展[J]. 中国实用内科杂志, 2009, 29(12): 1145-1146.
5. 　Brzozowski T, Konturek PC, Konturek SJ, et al. Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin[J]. Int J Colorectal Dis, 2003, 18(4): 320-329.
6. 　Kwiecień S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury[J]. J Physiol Pharmacol, 2002, 53(1): 39-50.
7. 　张宏亮, 徐杨, 范晓. 不同病因导致的应激性胃黏膜损伤中环氧化酶-2的改变[J]. 华西医学, 2010, 25(5): 833-836.
8. 　何绍珍, 任建林. 乙醇对胃黏膜作用机制的研究进展[J]. 世界华人消化杂志, 2005, 13(21): 2591-2596.
9. 　吴燕燕, 郭勇, 邹妤婕. 泮托拉唑治疗急性酒精中毒后胃黏膜损伤的疗效观察[J]. 中国药房, 2011, 22(28): 2650-2652.
10. 　Sibilia V, Rindi G, Pagani F, et al. Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action[J]. Endocrinology, 2003, 144(1): 353-359.

West China Medical Journal

Research on Efficiency of H2 Receptor Antagonists and Proton Pump Inhibitors in Alleviating Gastric Mucosal Lesions Caused by Acute Alcohol Intoxication

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