The Expression and Clinical Significance of P53, Epidermal Growth Factor Receptor and Ki-67 in Different Kinds of Breast Infiltrative Ductal Cancer_West China Medical Journal

Authors：

WANG Lei ,  SONG Linhong , ZHU Hong , FU Jing , LI Ke

Department of Pathology, Sichuan Academy of Medical sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

SONG Linhong, Email: tutou2000@163.com

Keywords：

乳腺肿瘤; 癌，导管，浸润性; 免疫表型分型; P53; 表皮生长因子受体; 人类表皮生长因子受体2; Ki-67

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目的　探讨不同分子分型乳腺浸润性导管癌手术病例标本中P53、表皮生长因子受体（EGFR）和Ki-67的表达及临床意义。方法　采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶连接法法对2010年1月－2011年7月446例乳腺浸润性导管癌患者标本进行分子分型，并同时检测其P53、EGFR、Ki-67等的表达。结果　P53和Ki-67在人类表皮生长因子受体2（HER2）过表达型、基底细胞样型、未分类型中的表达明显强于管腔A型及管腔B型（P＜0.05）；HER2过表达型和未分类型中的EGFR表达明显强于管腔A型及管腔B型（P＜0.05）。结论　在使用雌激素受体、c-erbB-2等指标对浸润性导管癌进行分子分型时同时检测P53、EGFR及Ki-67等标记物，有助于更加精准的评估肿瘤的生物学行为及预后，对靶向药物的个体化治疗提供参考和疗效预测有重要意义。

Citation： WANG Lei,SONG Linhong,ZHU Hong,FU Jing,LI Ke. The Expression and Clinical Significance of P53, Epidermal Growth Factor Receptor and Ki-67 in Different Kinds of Breast Infiltrative Ductal Cancer. West China Medical Journal, 2012, 27(9): 1349-1353. doi: Copy

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9.	Mao XY, Fan CF, Zheng HC, et al. P53 nuclear accumulation and ER alpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women [J]. J Exp Clin Cancer Res, 2010, 29(8): 112.
10.	曾敏. survivin 在乳腺癌中的表达及其与P53基因的关系[J]. 中华实用诊断与治疗杂志, 2009, 23(12): 1181-1183.
11.	Yuen PM, Ng PS, Leung PL, et al. Outcome in laparoscopic management of persistent adnexal mass during the second trimester of the second trimester of pregnancy[J]. Surg Endosc, 2004, 18(9): 1354-1357.
12.	Hanprasertpong J, Tungsinmunkong K, Chichareon S, et al. Correlation of P53 and Ki-67 (MIB-1) expressions with clinicopathological feat ures and prognos is of early stage cervical squamous cell carcinomas[J]. J Obstet Gynaecol Res, 2010, 36(3): 572-580.
13.	Tzaida O, Gogas H, Dafni U, et al. Evaluation of the prognostic and predictive value of HER-1/EGFR in breast cancer patients participating in a randomized study with dose-dense sequential adjuvant chemotherapy[J]. Oncology, 2007, 72(5-6): 388-396.
14.	Wu M, Jung L, Zhou J, et al. Dissecting genetic requirements of human breast tumorigenes is in a tissue transgenic model of human breast cancer in mice[J]. Proc Natl Acad Sci USA, 2009, 106(17): 7022-7077.
15.	Zhang Y, Opresko L, Shankaran H, et al. HER/ErbB receptorin teractions and signaling patterns in human mammary epithelialcells[J]. BMC Cell Biol, 2009, 10: 78-80.

1. 　Elston CW, Ellis IO. Classification of malignant breast disease[M]// Elston CW, Ellis IO. The breast. Systemic pathology. 3rd ed. Edinburgh: Churchill Livingstone, 1998: 239-247.
2. 　唐平, 魏兵, Hicks DG, 等. 乳腺癌的分子分类及其临床应用[J]. 中华病理学杂志, 2009, 38(1): 13-17.
3. 　Setiawan VW, Monroe KR, Wilkens LR, et al. Breast cancer risk factors defined by estrogen and progesterone receptor status: the multiethnic cohort study[J]. Am J Epidemiol, 2009, 169(10): 1251-1259.
4. 　Demonty G, Bernard-Marty C, Puglisi F, et al. Progress and new standards of care in the management of HER-2 positive breast cancer[J]. Eur J Cancer, 2007, 43(3): 497-509.
5. 　林敏, 陈忠清, 包芸, 等. 乳腺浸润性导管癌分子亚型与临床病理特征及预后的关系[J]. 中华病理杂志, 2010, 39(6): 372-376.
6. 　袁中玉, 王树森, 朱美琴, 等. 不同分子亚型乳腺癌的临床特征和预后[J]. 中华肿瘤杂志, 2008, 30(6): 456-461.
7. 　Calza S, Hall P, Auer G, et al. Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients[J]. Breast Cancer Res, 2006, 8(4): R34.
8. 　Shirley SH, Rundhaug JE, Tian J, et al. Transcriptional regulation of estrogen receptor-alpha by P53 in human breast cancer cells[J]. Cancer Res, 2009, 69(16): 3405-3414.
9. 　Mao XY, Fan CF, Zheng HC, et al. P53 nuclear accumulation and ER alpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women [J]. J Exp Clin Cancer Res, 2010, 29(8): 112.
10. 　曾敏. survivin 在乳腺癌中的表达及其与P53基因的关系[J]. 中华实用诊断与治疗杂志, 2009, 23(12): 1181-1183.
11. 　Yuen PM, Ng PS, Leung PL, et al. Outcome in laparoscopic management of persistent adnexal mass during the second trimester of the second trimester of pregnancy[J]. Surg Endosc, 2004, 18(9): 1354-1357.
12. 　Hanprasertpong J, Tungsinmunkong K, Chichareon S, et al. Correlation of P53 and Ki-67 (MIB-1) expressions with clinicopathological feat ures and prognos is of early stage cervical squamous cell carcinomas[J]. J Obstet Gynaecol Res, 2010, 36(3): 572-580.
13. 　Tzaida O, Gogas H, Dafni U, et al. Evaluation of the prognostic and predictive value of HER-1/EGFR in breast cancer patients participating in a randomized study with dose-dense sequential adjuvant chemotherapy[J]. Oncology, 2007, 72(5-6): 388-396.
14. 　Wu M, Jung L, Zhou J, et al. Dissecting genetic requirements of human breast tumorigenes is in a tissue transgenic model of human breast cancer in mice[J]. Proc Natl Acad Sci USA, 2009, 106(17): 7022-7077.
15. 　Zhang Y, Opresko L, Shankaran H, et al. HER/ErbB receptorin teractions and signaling patterns in human mammary epithelialcells[J]. BMC Cell Biol, 2009, 10: 78-80.

West China Medical Journal

The Expression and Clinical Significance of P53, Epidermal Growth Factor Receptor and Ki-67 in Different Kinds of Breast Infiltrative Ductal Cancer

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