The Clinico-pathological Features of Malignant Breast Lymphoma_West China Medical Journal

Authors：

LIU Xuejuan

Department of Thyroid, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

Keywords：

乳腺; 恶性淋巴瘤; 临床分析

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【摘要】　目的　探讨乳腺恶性淋巴瘤的临床病理特征、治疗方式及其与预后关系。　方法　 1980年1月-2007年12月对收治的21例乳腺恶性淋巴瘤患者的临床病理特点、诊断和治疗方法进行回顾性分析。　结果　 21例乳腺恶性淋巴瘤患者均为女性，中位年龄47岁；其中原发性乳腺恶性淋巴瘤18例，继发性恶性淋巴瘤3例。原发性乳腺恶性淋巴瘤均为非霍奇金淋巴瘤，B细胞来源为主，大多为术后诊断，治疗均采用手术+化学疗法。　结论　乳腺恶性淋巴瘤治疗应强调手术，化学疗法和放射治疗的综合治疗。
【Abstract】　Objective　 To study the clinico-pathological features and treatment modality of malignant breast lymphoma, and their relationships with the prognosis of the disease.　Methods　 The clinico-pathological features, diagnosis and treatment methods of 21 cases of malignant breast lymphoma diagnosed between January 1980 and December 2007 were analyzed retrospectively and related domestic and overseas literature was reviewed.　Results　 Among the 21 female patients, 18 had primary breast lymphoma (PBL), 3 had secondary breast lymphoma. All cases of PBL were non-Hodgkin’s lymphoma with mainly B cells as the origin. The median age of the patients was 46.5 years old. Most of the cases were diagnosed postoperatively and all patients were treated by operation combined with chemotherapy. Related literature reviewing showed that clinical staging and treatment modality were important factors of prognosis.　Conclusion　 In treating malignant breast lymphoma, operation and chemoradiotherapy should be combined together to get a better result.

Citation： LIU Xuejuan. The Clinico-pathological Features of Malignant Breast Lymphoma. West China Medical Journal, 2011, 26(2): 207-209. doi: Copy

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1. 　朱元喜. 20例乳腺原发性恶性淋巴瘤临床病理及预后分析[J]. 中国肿瘤临床, 2008, 28(7): 504-507.
2. 　吴小红. 乳腺原发性恶性淋巴瘤15例临床分析[J]. 癌, 1999, 18(3): 311-313.
3. 　Duncan VE, Reddy VV, Jhala NC, et al. Non-Hodgkin’s lymphoma of the breast: a review of 18 primary and secondary cases[J]. Ann Diagn Pathol, 2006, 10(3): 144-148.
4. 　胡春宏. 原发性乳腺淋巴瘤(15例报告及文献复习)J].中国肿瘤临床, 2001, 28(7): 501-503.
5. 　Aviles A, Delgado S, Nambo MJ, et al. Primary breast lymphoma: results of a controlled clinical trial[J]. Oncology, 2005, 69(3): 256-260.
6. 　Jeanneret-Sozzi W, Taghian A, Epelbaum R, et al. Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study[J]. BMC Cancer, 2008, 1(8): 86.
7. 　Wong WW, Schild SE, Halyard MY, et al. Primary non-Hodgkin lymphoma of the breast: the mayo clinic experience[J]. J Surg Oncol, 2002, 80(1): 19-25.
8. 　Jennings WC, Baker RS, Murray SS, et al. Primary breast lymphoma: the role of mastectomy and the importance of lymph node status[J]. Ann Surg, 2007, 245(5): 784-789.
9. 　胡巧英. 乳腺原发性恶性淋巴瘤[J]. J Pract Oncol, 2001, 16(3): 194-195.
10. 　Abbondanzo SL, Seidman DJ, Lefkowweits M, et al. Primary diffuse large B-cell lymphoma of clinicopathologic study of 31 cases[J]. Pathol Res Pract, 1996, 192(1): 37-43.
11. 　Ha CS, Dubey P, Goyal LK, et al.Localized primary non-Hodgkin’s lymphoma of the breast[J].Am J Clin Oncol, 1998, 21(4): 376-380.
12. 　王黎明. 原发性乳腺恶性淋巴瘤21例临床分析[J]. 实用癌症杂志, 2004, 7(4): 401-405.

West China Medical Journal

The Clinico-pathological Features of Malignant Breast Lymphoma

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