Bundle Therapy in Five Severe Patients with Influenza A (H1N1)_West China Medical Journal

Authors：

YANG Mingquan , XIAO Guohui

Intensive Care Uint, the First People’s Hospital of Zigong, Zigong, Sichuan 643000, P. R. China;

Corresponding author：

Keywords：

甲型HlN1流感; 危重患者; 集束化治疗

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【摘要】　目的　探讨甲型H1N1流感危重症患者的抢救疗效。　方法　 2009年10月－2010年1月，对我院ICU收治5例甲型H1N1流感危重症患者采用集束化治疗方案进行救治，并就患者的器官功能变化进行评价。　结果　 5例患者平均住院天数为（11.8±5.59）d，4 例存活，1例死亡。存活患者在治疗过程中急性生理和既往健康（APACHE）Ⅱ、多器官功能障碍综合征评分（MODS）、全身性感染相关的器官衰竭评分（SOFA）总体呈逐渐下降趋势。死亡者APACHEⅡ、SOFA评分均呈逐渐升高趋势。　结论　对甲型H1N1流感危重症患者采取集束化救治疗效良好。
【Abstract】　Objective　 To explore the effect of bundle therapy on severe patients with influenza A (H1N1).　Methods　 Bundle therapy were used in 5 severe patients with influenza A from October 2009 to January 2010. The patients’ organ dysfunction were observed for.　Results　 The average in-hospital duration was (11.80±5.59) days. Four patients survived and one died with the survival ratio of 80%. Acute physiology and chronic health evaluation (APACHE) II score, Multiple organ dysfunction syndrome (MODS) score and sepsis-related organ failure assessment (SOFA) score gradually decreased in 4 survived patients, while gradually increased in the died patient.　Conclusion　 Bundle therapy is effective on patients with severe influenza A.

Citation： YANG Mingquan,XIAO Guohui. Bundle Therapy in Five Severe Patients with Influenza A (H1N1). West China Medical Journal, 2011, 26(7): 1022-1024. doi: Copy

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1. 　中华人民共和国卫生部. 甲型H1Nl流感诊疗方案(2009年试行版第三版)[J]. 传染病信息, 2009, 22(3): 1-3.
2. 　Agarwal PP, Cinti S, Kazerooni EA. Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus(S-OlV) infection[J]. AJR Am J Roentgenol, 2009, 193(6): 1488-1493.
3. 　朱玉春, 王建良, 刘丽华, 等. 6例重症甲型H1N1流感的肺部CT影像分析[J]. 中国医学影像学杂志, 2011, 19(2): 149-152.
4. 　Chowell G, Bertozzi SM, Cochero MA, et al. Severe respiratory disease concurrent with the circulation of HlN1 influenza[J]. N Engl J Med, 2009, 361(7): 674-679.
5. 　Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, et al. Pneumonia and respiratory failure from swine-origin inf1uenza A(H1N1)in Mexico[J]. N Engl J Med, 2009, 361(7): 680-689.
6. 　李华, 马如存. 青海省75例重症甲型H1N1流感患者临床分析[J]. 中国危重病急救医学, 2010, 22(3): 164-165.
7. 　李秀惠, 夏章, 田一梅, 等. 新型甲型H1 N1流感重症17例临床特征分析[J]. 环球中医药, 2010, 3(1): 13-17.
8. 　寇国先, 熊凤鸣, 韩爱华, 等. 重症与危重甲型H1N1流感40例临床分析[J]. 浙江临床医学, 2011, 13(3): 262-264.

West China Medical Journal

Bundle Therapy in Five Severe Patients with Influenza A (H1N1)

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