枸橼酸他莫昔芬片与中成药在乳腺良性增生的近期疗效对比_West China Medical Journal

Authors：

王晓东 ¹ , 陈玉娟 ¹ , 金显峰 ² , 梁法清 ³

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Keywords：

乳腺增生; 他莫昔芬; 中成药

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【摘要】　目的　评价他莫昔芬片与市售中成药乳增宁、乳疾灵治疗乳腺良性增生的疗效。　方法　自2009年8月－2010年6月，将门诊就诊240例乳腺增生疾病患者，随机分为两组，每组各120例。治疗组应用他莫昔芬，对照组应用中成药治疗。以疼痛减轻和包块缩小为指标，对两组疗效做比较。　结果　治疗组有效率为89.83%，对照组有效率为67.86%。两组比较差异有统计学意义（P lt;0.05）。　结论　采用他莫昔芬片治疗女性乳腺良性增生性疾病，近期疗效优于市售中成药。

Citation： 王晓东,陈玉娟,金显峰,梁法清. 枸橼酸他莫昔芬片与中成药在乳腺良性增生的近期疗效对比. West China Medical Journal, 2011, 26(7): 1082-1083. doi: Copy

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1. 　Mansel RF, Wisbey JR, Hughes LE. Controlled trial of the antigonadotrophin danazol in painful nodular banign breast disease[J]. Lancet, 1982, 1: 928.
2. 　Doberl A,Tobiassen T, Rasmussen T. Treatment of recurrent cyclical mastodynia in patients with fibrocystic breast disease[J]. Acta Obstet Gynecol Scand Suppl, 1984, 123: 177.
3. 　Fentiman IS, Caleffi D, Brame K, et al. Double-blind controlled trial of tamoxifen therapy for mastalgia[J]. Lancet, 1986, 1: 287.
4. 　Messinis IE, Lolis D.s Treatment of premenstrual mastagia with tamoxifen[J]. Acta Obstet Gynecol Scand, 1988, 67: 307.
5. 　Ortiz-Mendoza CM,s Lucas Florea MA, Domville Ede G. Mastagia treatment with tamoxifen[J]. Ginecol Obstet Mex, 2003, 71: 502-507.
6. 　吴祥德, 董守义. 乳腺疾病诊治[M]. 北京: 人民卫生出版社, 2000: 216-223.
7. 　许良中. 乳腺病理学[M]. 上海: 上海医科大学出版社, 1999: 41-51.
8. 　周利华, 陈萍, 龙洪娣. 软坚散结法治疗乳腺增生260例临床观察[J]. 临床心身疾杂志,2007, 9(5): 17.
9. 　Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer.Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study[J]. J Natl Cancer Inst, 1998, 90: 1371.

West China Medical Journal

枸橼酸他莫昔芬片与中成药在乳腺良性增生的近期疗效对比

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