Expression of ΔNP63/TAP63 in Epithelium Ovarian Cancer and Its Clinicopathological Features_West China Medical Journal

Authors：

WANG Yan ¹ , YANG Yezhou ¹ , XIE Lan ¹ , YANG Nian ¹ ,  GUO Bo ²

1. Department of Obstetric and Gynecology, People′s Hospital of Sichuan Province, Chendu, Sichuan 610072, P. R. China; 2. Department of ophthalmology, West China Hospital, Sichuan University, Chendu, Sichuan 610041, P. R. China;

Corresponding author：

GUO Bo, Email: wang3yan@yahoo.com.cn

Keywords：

上皮性卵巢癌; ΔNP63/TAP63; 荧光定量聚合酶链反应

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【摘要】　目的　研究ΔNP63/TAP63在上皮性卵巢肿瘤组织中的表达及其与临床病理特征的关系。　方法　运用荧光定量聚合酶链反应方法检测2002年-2004年54例卵巢上皮性肿瘤中ΔNP63/TAP63的基因水平。　结果　 33例卵巢上皮细胞癌组织中ΔNP63的表达高于21例良性上皮性肿瘤中组织。卵巢上皮细胞癌中的表达强度与肿瘤组织病理学分期相关（P lt;0.05），良性肿瘤的表达低于恶性肿瘤（P lt;0.05）。ΔNP63的表达高于TAP63（P lt;0.05）；各组间TAP63的表达差异无统计学意义（P gt;0.05）。　结论　 ΔNP63在上皮性卵巢癌中高表达，可能成为上皮性卵巢癌诊断及预后的分子标志物。
【Abstract】　Objective　 To explore the expression of ΔNP63 / TAP63 in human epithelial ovarian tumor tissues and its relationship with the clinicopathological features. 　Methods　 Fluorescent quantitative PCR method was used to detect 54 cases of ΔNP63 / TAP63 gene level in 54 patients with epithelial ovarian tumors diagnosed between 2002 and 2004.　Results　 ΔNP63 expression in the 33 cases of ovarian epithelial cell carcinoma was higher than that in the 21 cases of benign epithelial tumor tissue. The expression in ovarian epithelial cell carcinoma was concerned with the pathological staging of tumor (P lt;0.05); the expression in benign tumors was lower than that in the malignant tumors (P lt;0.05). In all cases, the expression of ΔNP63 was higher than that of TAP63 (P lt;0.05); the difference in the expression of TAP63 among the groups was not significant (P gt;0.05).　Conclusion　 ΔNP63 in epithelial ovarian cancer is highly expressed, which may become the molecular makers with diagnosis and prognosis of epithelial ovarian cancer diagnosis in the future.

Citation： WANG Yan,YANG Yezhou,XIE Lan,YANG Nian,GUO Bo. Expression of ΔNP63/TAP63 in Epithelium Ovarian Cancer and Its Clinicopathological Features. West China Medical Journal, 2011, 26(9): 1379-1381. doi: Copy

1.	曹泽毅. 中华妇产科学[M]. 北京: 人民卫生出版社, 2004: 2163.
2.	Kocken M, Baalbergen A, Snijders PJ, et al. High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix. [J]. Gynecol Oncol, 2011, 122(2): 297-302.
3.	王晓惠, 彭芝兰, 雷军强, 等. 卡铂诱导卵巢癌细胞株OVCA_3凋亡中p63及p53基因mRNA的变化[J]. 兰州大学学报(医学版), 2010, 36(4): 8-10.
4.	Osada M, Ohba M, Kawabara C, et al. Cloning and functional analysis of human P51,　which structurally and functional resembles P53[J]. Nat Med, 1998, 7(4): 839-843.
5.	Levrero M, Laurenzi VD, Costanzo A, et al. Structure,function and regulation of P63 and P73[J]. Cell Death Differ [J], 1999, 6(12): 1154-1161.
6.	Irwin MS, Kaelin WG. Role of the newer P53 family proteins in malignancy[J]. Apoptosis, 2001, 6(10): 17-19.
7.	Parsa R, Yang A, McKeon F, et al. Association of P63 with proliferative potential in n ormal and neoplastic human keratinocytes[J]. J Invest Dermatol, 1999, 113(10): 1099-1105.
8.	Glickman JN, Yang A, Shahsafaei A, et al. Expression of P53-related protein P63 in the gastrointestinal tract and in esophageal metaplastic disorders [J]. Hum Pathol, 2001, 32(11): 1157-1165.
9.	Wu GJ, Nomoto SJ, Hoque MO, et al. ΔNP63α and TAP63α regulate tanscription of genes with distinct biological function in cancer and development [J]. Cancer Res, 2003, 63(15): 2351-2357.
10.	司少艳, 张建中. P63基因研究进展[J]. 世界华人消化杂志, 2003, 11(5): 606-609.
11.	Elsa R, Flores, Kenneth Y, et al. P63 and P73 are required for P53 dependent apoptosis in response to DNA damage[J]. Nature, 2002, 416(4): 560-564.
12.	Wu GJ, Nomoto SJ, Hoque MO, et al. ΔNP63αand TAP63αregulate tanscription of genes with distinct biological function in cancer and development [J]. Cancer Res, 2003, 63(15): 2351-2357.

1. 　曹泽毅. 中华妇产科学[M]. 北京: 人民卫生出版社, 2004: 2163.
2. 　Kocken M, Baalbergen A, Snijders PJ, et al. High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix. [J]. Gynecol Oncol, 2011, 122(2): 297-302.
3. 　王晓惠, 彭芝兰, 雷军强, 等. 卡铂诱导卵巢癌细胞株OVCA_3凋亡中p63及p53基因mRNA的变化[J]. 兰州大学学报(医学版), 2010, 36(4): 8-10.
4. 　Osada M, Ohba M, Kawabara C, et al. Cloning and functional analysis of human P51,　which structurally and functional resembles P53[J]. Nat Med, 1998, 7(4): 839-843.
5. 　Levrero M, Laurenzi VD, Costanzo A, et al. Structure,function and regulation of P63 and P73[J]. Cell Death Differ [J], 1999, 6(12): 1154-1161.
6. 　Irwin MS, Kaelin WG. Role of the newer P53 family proteins in malignancy[J]. Apoptosis, 2001, 6(10): 17-19.
7. 　Parsa R, Yang A, McKeon F, et al. Association of P63 with proliferative potential in n ormal and neoplastic human keratinocytes[J]. J Invest Dermatol, 1999, 113(10): 1099-1105.
8. 　Glickman JN, Yang A, Shahsafaei A, et al. Expression of P53-related protein P63 in the gastrointestinal tract and in esophageal metaplastic disorders [J]. Hum Pathol, 2001, 32(11): 1157-1165.
9. 　Wu GJ, Nomoto SJ, Hoque MO, et al. ΔNP63α and TAP63α regulate tanscription of genes with distinct biological function in cancer and development [J]. Cancer Res, 2003, 63(15): 2351-2357.
10. 　司少艳, 张建中. P63基因研究进展[J]. 世界华人消化杂志, 2003, 11(5): 606-609.
11. 　Elsa R, Flores, Kenneth Y, et al. P63 and P73 are required for P53 dependent apoptosis in response to DNA damage[J]. Nature, 2002, 416(4): 560-564.
12. 　Wu GJ, Nomoto SJ, Hoque MO, et al. ΔNP63αand TAP63αregulate tanscription of genes with distinct biological function in cancer and development [J]. Cancer Res, 2003, 63(15): 2351-2357.

West China Medical Journal

Expression of ΔNP63/TAP63 in Epithelium Ovarian Cancer and Its Clinicopathological Features

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