难治性哮喘中Th1/Th2失衡机制_West China Medical Journal

Authors：

胡鑫 ¹ , 沈唯薇 ²

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Keywords：

难治性哮喘; Th1/Th2失衡; 干扰素-γ; 白介素; 转化生长因子-β

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【摘要】　支气管哮喘是一种由多种细胞包括气道的炎性细胞、结构细胞和细胞组分参与的气道慢性炎症性疾病。临床上少数患者通过充分的哮喘治疗包括使用全身性激素治疗后仍不能有效控制，通常称为“难治性哮喘”。免疫反应在难治性哮喘发病机制中起重要作用，而Th1/Th2失衡贯穿于难治性哮喘发病的整个过程。现就难治性哮喘中Th1/Th2失衡机制，以及影响因子（干扰素-γ、白介素-12、白介素-4、白介素-17，白介素-33和转化生长因子-β等）的研究作一综述，以深入探讨难治性哮喘的发病机制。

Citation： 胡鑫,沈唯薇. 难治性哮喘中Th1/Th2失衡机制. West China Medical Journal, 2011, 26(9): 1428-1431. doi: Copy

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14.	Rook W. TGF-β1 paradox in asthma[J].　Trends Immunol, 2001, 22(6): 299.
15.	Minshall EM, Leung NYM, Martin RJ, et al. Eosinophil-assiociated TGF-β1 mRNA expression and airwalls fibrosis in bronchial asthma[J]. Am J Respire Cell Mol Biol, 1997, 17(3):326-333.
16.	Mak JC, Rousell J, Haddad EB, et al. Transforming growth factor-beta1 inhibits beta2-adrenoceptor gene transcription[J]. Naunyn Schmiedebergs Arch Pharmacol, 2000, 362(6): 520-525.
17.	Préfontaine D, Lajoie-kadoch S, Foley S, et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cell[J]. J Immunol, 2009, 183(8): 5094-5103.
18.	Wegmann M. Th2 cells as targets for therapeutic intervention in allergic bronchial asthma[J]. Expert Rev Mol Diagn, 2009, 9(1): 85-100.
19.	Hartl D, Koller B, Mehlhon AT, et al. Quantitative and functional impairment of pulmonary CD4+ CD25hi regulatory T cells in pediatric asthma[J].J Allergy Clin Immunol, 2007, 119(5): 1258-1266.
20.	符州, 杨锡强, 李成荣. 甲基强的松龙对哮喘患儿PBMC分泌TH源性细胞因子的影响作用研究[J]. 中华微生物学和免疫学杂志, 2000, 20(6): 548.
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1. 　陈灏珠. 实用内科学[M]. 10版. 北京: 人民卫生出版社, 1999: 1379-1398.
2. 　Redington AE, Howarth PH. Airway wall remodelling in asthma[J]. Thorax, 1997, 52(4): 310-312.
3. 　Del Prete G, Maggi E, Romagnani S. Human Th1 and Th2 cells: functional properties, mechanisms of regulation,and role in disease[J]. Lab Invest, 1994, 70(3): 299-306.
4. 　Piccinni MP, Giudizi MG, Biagiotti R, et al. Progesterone favorsthe development of human T helper cells producing Th2-type cytokines and promots both IL-4 production and membrane CD30 expression in established Th1 cell clones[J]. J Immunol, 1995, 155(1): 128-133.
5. 　Blink SE, Fu YX. IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation[J]. Cell Immunol, 2010, 264(1): 54-60.
6. 　Varga EM, Wachholz P, Nouri-Aria KT, et al. T cells from human allergen-induced late asthmatic responses express IL-12 receptor beta 2 subunit mRNA and respond to IL-12 in vitro[J]. J Immunol, 2000, 165(5): 2877-2885.
7. 　Choi IS, Cui Y, Koh YA, et al. Effects of dehydroepiandrosterone on Th2 cytokine production in peripheral blood mononuclear cells from asthmatics[J]. Korean J Intern Med, 2008, 23(4): 176-181.
8. 　Hamid QA, Minshall EM. Molecular pathyology of allergic disease[J]. J Allergy Clin Immunol, 2000, 105(1): 20-36.
9. 　Deo SS, Mistry KJ, Kakade AM, et al. Role played by Th2 type cytokines in IgE mediated allergy and asthma[J]. Lung India, 2010, 27(2): 66-71.
10. 　Xu Q, Leung DY, Kisich KO. Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mrna to glucocorticoid receptor in neutrophils[J]. J Biol Chem, 2000, 278(29): 27112-27118.
11. 　Cosmi L, Liotta F, Maggi E, et al. Th17 cell: new players in asthma pathogenesis[J]. J Allergy Clin Immunol, 2011, 66(8): 989-98.
12. 　Al-Ramli W, Prefontaine D, Chouiali F, et al. T(H) 17-associated cytokinase (IL-17A and IL-17F) in severe asthma[J]. J Allergy Clin Immunol, 2009, 123(5): 1185-1187.
13. 　Zhao Y, Yang J, Gao YD, et al. Th17 immunity in patients with allergic asthma[J]. Int Arch Allergy Immunol, 2010, 151(4): 297-307.
14. 　Rook W. TGF-β1 paradox in asthma[J].　Trends Immunol, 2001, 22(6): 299.
15. 　Minshall EM, Leung NYM, Martin RJ, et al. Eosinophil-assiociated TGF-β1 mRNA expression and airwalls fibrosis in bronchial asthma[J]. Am J Respire Cell Mol Biol, 1997, 17(3):326-333.
16. 　Mak JC, Rousell J, Haddad EB, et al. Transforming growth factor-beta1 inhibits beta2-adrenoceptor gene transcription[J]. Naunyn Schmiedebergs Arch Pharmacol, 2000, 362(6): 520-525.
17. 　Préfontaine D, Lajoie-kadoch S, Foley S, et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cell[J]. J Immunol, 2009, 183(8): 5094-5103.
18. 　Wegmann M. Th2 cells as targets for therapeutic intervention in allergic bronchial asthma[J]. Expert Rev Mol Diagn, 2009, 9(1): 85-100.
19. 　Hartl D, Koller B, Mehlhon AT, et al. Quantitative and functional impairment of pulmonary CD4+ CD25hi regulatory T cells in pediatric asthma[J].J Allergy Clin Immunol, 2007, 119(5): 1258-1266.
20. 　符州, 杨锡强, 李成荣. 甲基强的松龙对哮喘患儿PBMC分泌TH源性细胞因子的影响作用研究[J]. 中华微生物学和免疫学杂志, 2000, 20(6): 548.
21. 　Randolph DA, Stephens R, Carruthers CJ, et al. Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation[J].J Clin Invest, 1999, 104(8): 1021-1029.

West China Medical Journal

难治性哮喘中Th1/Th2失衡机制

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