Clinical Effect of Levamlodipine Combined with Atorvastatin on Blood Pressure in Patients with Hypertension_West China Medical Journal

Authors：

XU Fengcheng ,  LIU Tianhu , YAN Mingjun , ZENG Hongyan , YIN Xiaohua , CHEN Rong , WU Wanxi

Cardiovascular Department, the People′s Hospital of Pixian, Pixian, Sichuan 611730, P. R. China;

Corresponding author：

LIU Tianhu, Email: xfcj1001@163.com

Keywords：

阿托伐他汀; 左旋氨氯地平; 降脂治疗; 高血压

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【摘要】　目的　探讨阿托伐他汀强化降脂治疗和左旋氨氯地平联用对高血压患者血压的影响。　方法　选择2009年1月-2010年11月住院及门诊原发性高血压合并高脂血症患者196例，均给予左旋氨氯地平和阿托伐他汀治疗8周后，复查血脂，从其中选择血脂正常者120例，随机分为对照组（单用左旋氨氯地平组）和治疗组（继续左旋氨氯地平联用阿托伐他汀），继续治疗20周后的血压情况。　结果　两组治疗20周后，治疗组收缩压和舒张压均较对照组下降明显，组间差异有统计学意义（P lt;0.01），治疗组优于对照组。　结论　高血压合并高脂血症患者，使用左旋氨氯地平降压和阿托伐他汀降脂治疗时，在血脂降至正常后，继续同时左旋氨氯地平降压和阿托伐他汀强化降脂治疗，降压效果优于单用左旋氨氯地平。
【Abstract】　Objective　 To investigate the effects of levamlodipine combined with atorvastatin on blood pressure in patients with primary hypertension.　Methods　 Between January 2009 and November 2010, 196 patients with hypertension and hyperlipidemia in the outpatient and inpatient departments of our hospital were given levamlodipine and atorvastatin for 8 weeks, after which 120 patients with normal blood lipid were chosen and randomly divided into the control group (treated only by levamlodipine) and the treatment group (treated by levamlodipine combined with atorvastatin). After 20 weeks of the treatment, we observed their blood pressure.　Results　 After twenty weeks of treatment, the diastolic and systolic pressure was significantly lower in the treatment group than that in the control group (P lt;0.01).　Conclusion　 For patients with hypertension and hyperlipidemia who have undergone the treatment by levamlodipine and atorvastatin, after their blood lipid level decreases to normal, the continuous enhanced treatment by the two drugs has a better efficacy compared with the therapy of single levamlodipine in decreasing the blood lipid.

Citation： XU Fengcheng,LIU Tianhu,YAN Mingjun,ZENG Hongyan,YIN Xiaohua,CHEN Rong,WU Wanxi. Clinical Effect of Levamlodipine Combined with Atorvastatin on Blood Pressure in Patients with Hypertension. West China Medical Journal, 2011, 26(11): 1633-1635. doi: Copy

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2.	Liao Y, Zhao H,Ogai A, et al. Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation[J]. Hypertens Res, 2008, 31(2): 335-344.
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6.	赵水平, 胡大一. 心血管病诊疗指南解读[M]. 3版. 北京: 人民卫生出版社, 2008: 8-39.
7.	Ge CJ, Lu SZ, Chen YD, et al. Synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling and C-reactive protein in hypertensive patients with primary hypercholesterolemia[J]. Heart Vesse1s, 2008, 23(2): 91-95.
8.	Asher J, Houston M. Statins and C-reactive protein levels[J]. Clin Hypertens (Greenwich), 2007, 9(8): 622-628.
9.	Castro PF, Miranda R, Verdejo HE. Pleiotropic effects of atorvastatin in heart failure; role in oxidative stress, inflammation, endothelial function, and exercise capacity[J]. J Heart Lung Transplant, 2008, 27(4): 435-441.
10.	Mondo CK, Yang WS, Su JZ, et al. Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat[J]. Clin Exp Hypertens, 2006, 28(5): 499-509.
11.	Rikitake Y, Liao JK. Rho CTPases, statins, and nitric Oxide[J].Circ Res, 2005, 97(12): 1232-1235.
12.	Borghi C, Prandin MG, Costa FV, et al. Use of stains and blood pressure control in hypertensive patients with hypercholesterolemia[J].J Cardiovase Pharmacol, 2000, 35(4): 549-555.
13.	Krzesinski JM. Firest evidence of greater cardiovascular protective effects of newer as compared to old antihypertensive drugs ireatments: the ASCOT-BPLA results[J].Rev Med Liege, 2005, 60(10): 820-826.
14.	Ferrie KE, Muhlmann MH, Baguet JP, et al. Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic Hypertension[J]. J Am Coll Cardiol, 2002, 39(6): 1020-1025.
15.	Golobm BA, Dimsdle JE, White HL, et al. Reduction in blood pressure with stations,results from UCSD Statin Study,a randomized trial[J]. Arch Intern Med, 2008, 168(7): 721-727.

1. 　Kanbay M,Yildirir A, Bozbas H, et al. Statin therapy helps to controlblood pressure levels in hypertensive dyslipidemic patients[J]. Ren Fail, 2005, 27(3): 297-303.
2. 　Liao Y, Zhao H,Ogai A, et al. Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation[J]. Hypertens Res, 2008, 31(2): 335-344.
3. 　Paulsen L, Holm C, Bech JN, et al. Eiffects of statins on renal sodium and water handling:acute and short-term eiffects of atorvastatin on renal haemodynamics,tubular function, vasoactive hormones, blood pressure and pulse rate in healthy, normocholesterolemic humans[J]. Nephrol Dial Transplant, 2008, 23(5): 1556-1561.
4. 　Paulsen L, Holst LM, Bech JN, et al. Glomerular filtration rate and blood pressure are unchanged by increased sodium intake in atorvastatin-treated healthy men[J]. Scand J Clin Lab Invest, 2009, 69(3): 323-329.
5. 　Li JJ, Fang CH. C-reactive potein is not only an inflammatory maker but also a direct cause of cardiovascular disease[J]. Med Hypotheses, 2004, 62(4): 499-506.
6. 　赵水平, 胡大一. 心血管病诊疗指南解读[M]. 3版. 北京: 人民卫生出版社, 2008: 8-39.
7. 　Ge CJ, Lu SZ, Chen YD, et al. Synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling and C-reactive protein in hypertensive patients with primary hypercholesterolemia[J]. Heart Vesse1s, 2008, 23(2): 91-95.
8. 　Asher J, Houston M. Statins and C-reactive protein levels[J]. Clin Hypertens (Greenwich), 2007, 9(8): 622-628.
9. 　Castro PF, Miranda R, Verdejo HE. Pleiotropic effects of atorvastatin in heart failure; role in oxidative stress, inflammation, endothelial function, and exercise capacity[J]. J Heart Lung Transplant, 2008, 27(4): 435-441.
10. 　Mondo CK, Yang WS, Su JZ, et al. Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat[J]. Clin Exp Hypertens, 2006, 28(5): 499-509.
11. 　Rikitake Y, Liao JK. Rho CTPases, statins, and nitric Oxide[J].Circ Res, 2005, 97(12): 1232-1235.
12. 　Borghi C, Prandin MG, Costa FV, et al. Use of stains and blood pressure control in hypertensive patients with hypercholesterolemia[J].J Cardiovase Pharmacol, 2000, 35(4): 549-555.
13. 　Krzesinski JM. Firest evidence of greater cardiovascular protective effects of newer as compared to old antihypertensive drugs ireatments: the ASCOT-BPLA results[J].Rev Med Liege, 2005, 60(10): 820-826.
14. 　Ferrie KE, Muhlmann MH, Baguet JP, et al. Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic Hypertension[J]. J Am Coll Cardiol, 2002, 39(6): 1020-1025.
15. 　Golobm BA, Dimsdle JE, White HL, et al. Reduction in blood pressure with stations,results from UCSD Statin Study,a randomized trial[J]. Arch Intern Med, 2008, 168(7): 721-727.

West China Medical Journal

Clinical Effect of Levamlodipine Combined with Atorvastatin on Blood Pressure in Patients with Hypertension

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