Association Between Serum Cystatin C Concentration and Lipid, Hs-C Reactive Protein in the Elderly with Diabetes_West China Medical Journal

Authors：

SUN Yan , LIAO Shuping

Department of physical examination, Shenzhen People’s Hospital, Second Hospital Affilliatid to Jinan University, Shenzhen 518020, P.R.China;

Corresponding author：

Keywords：

血清胱抑素C; 血脂; 高敏C反应蛋白; 糖尿病; 老年

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【摘要】目的 探讨老年糖尿病患者血清胱抑素C与血脂及高敏C反应蛋白的关系。方法 2008年5月-2009年10月糖尿病患者共141例，其中糖尿病合并症组68例，单纯糖尿病组73例；另选取对照组51例。对入选者的血清胱抑素C、血脂及高敏C反应蛋白进行分析。结果老年男女糖尿病合并症组血清胱抑素C、高敏C反应蛋白、总胆固醇、甘油三酯及低密度脂蛋白胆固醇最高、高密度脂蛋白胆固醇最低，与对照组比较有统计学意义（P lt;0.05）、与单纯糖尿病组比较，无统计学意义（P gt;0.05）。老年男女单纯糖尿病组高敏C反应蛋白、总胆固醇、甘油三酯高于对照组，组间比较，有统计学意义（P lt;0.05）。老年男女单纯糖尿病组血清胱抑素C与对照组比较，无统率学意义（P gt;0.05）。老年女性单纯糖尿病组低密度脂蛋白胆固醇与对照组比较，有统计学意义（P lt;0.05）。老年男性糖尿病二组与对照组血清胱抑素C低于老年女性糖尿病二组与对照组，组间比较，无统计学意义（P gt;0.05）。老年男性糖尿病患者血清胱抑素C与高敏C反应蛋白及血脂不相关。老年女性糖尿病合并症组血清胱抑素C与空腹血糖正相关；单纯糖尿病组血清胱抑素C与高密度脂蛋白胆固醇负相关、与低密度脂蛋白胆固醇正相关、与高敏C反应蛋白不相关。结论老年糖尿病患者高脂、高糖及低度炎症状态下，血清胱抑素C水平较高。血脂对血清胱抑素C的影响可能存在性别差异。随着动脉粥样硬化的加重，血清胱抑素C有升高趋势。
【Abstract】 Objective To investigate the relationship between serum cystatin C concentration and lipid, hs-C reactive protein in the elderly with diabetes. Methods A total of 192 senile people form May 2008 to October 2009 were investigated. There were 141 patients with diabetes, in whom 68 were with cardiovascular and cor, cerebrovascular diseases, 73 were with diabetes only.There were 51 control subjects. The data of serum cystatin C, hs-CRP, TC, TG, HDL-C and LDL-C were analyzed. Results Serum cystatin C of elderly men was lower than that in elderly women, but no signifcant correlation between them was found (P gt;0.05). Serum cystatin C, hs-CRP, TC, TG and LDL-C was higher, and HDL-C was lower in male and female diabetes subjects with cardiovascular and cor, cerebrovascullar diseases, than that in control subjects (P lt;0.05). Serum hs-CRP, TC and TG were higher in the elderly with diabetes only, than that in control subjects (P lt;0.05). LDL-C was higher in senile women with diabetes only, than that in female control subjects (P lt;0.05). Serum cystatin C with LDL-C in elderly women with diabetes only, with FPG in female diabetes subjects with cardiovascular and cor, cerebrovascular diseases had position correlation (P lt;0.05). No correlation were observed between serum cystatin C and hs-CRP in male and female diabetes subjects, and lipid in male diabetes subjects. Conclusions We speculate that high serum lipid, high glucose and low level of inflammation may result in increasing of serum cystatin C in senily people with diabetes. The influence of serum lipid on serum cystatin C may be different in male and female senile people.Along with atherosclerotic aggravating, the level of serum cystatin C was increasing.

Citation： SUN Yan,LIAO Shuping. Association Between Serum Cystatin C Concentration and Lipid, Hs-C Reactive Protein in the Elderly with Diabetes. West China Medical Journal, 2010, 25(8): 1509-1512. doi: Copy

1.	Shi GP, Sukhova GK, Grubb A, et al. Cystatin C in human atherosclerosis and aortic aneurysms[J]. J Clin Invest, 1999, 104(9): 1191-1197.
2.	Yetkin E, Acikqoz N, Sivri N, et al. Increased plasma levels of cystatin C and transforming growth factor-beta1 in patients with coronary artery ectasia: can there be a potential interaction between cystatin C and transforming growth factor-factor-beta1[J]. Coron Artery Dis, 2007, 18(3): 211-214.
3.	Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis [J]. Science, 1986, 232(4746): 34-47.
4.	Toshima S, Hasegawa A, Kurabayashi M, et al. Circulating oxidized low density lipoprotein: a biochemical risk marker for coronary heart disease[J]. Arterioscler Thromb Vasc Biol, 2000, 20: 2243-2247.
5.	Report of expert committee on the diagonsis and classification of diabetes mellitus[J]. Diabetes Care, 2002, 25(Suppl 1): 5-20.
6.	中国高血压防治指南修订委员会. 中国高血压防治指南(2005年修订版)[J]. 高血压杂志, 2005, 13(增刊): 241.
7.	Uzun H, Ozmen Keles M, Ataman R, et al. Serum cystatin C level as a potentially good marker for impaired kidney function[J]. Clin Biochem, 2005, 38(9): 792-798.
8.	Galteau MM, Guyon M, Gueguen R, et al. Determination of serum cystatinC: biological variation and reference values[J]. Clin Chem Lab Med, 2001, 39(9): 850-857.
9.	Wilson PW, D’Agostino RB, Levy Daniel, et al. Prediction of Coronary Heart Disease Using Risk Factor Categories[J]. Circulation, 1998, 97(18): 1837-1847.
10.	Luc G, Bard J, Lesueur C, et al. Plasma cystatin-C and development of coronary heart disease: The PRIME Study[J]. Atherosclerosis, 185(2): 375-380.
11.	Ross R. Atherosclerosis-an inflammatory disease[J]. N Engl J Med, 1999, 340: 115-126.
12.	Randers E, Erlandsen EJ. Serum cystatin C as an endogenous marker of the renal function: a riview[J]. Clin Chem Lab Med, 37(4): 389-395.
13.	Dickinson DP, Zhao Y, Thiesse M, et al. Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11. 2[J]. Genomis, 1994, 24(1): 172-175.
14.	Bostom AG, Bausserman L, Jacques PF, et al. Cystatin C as a determinant of fasting plasma total homocysteine levels in coronary artery disease patients with normal serum creatinine[J]. Arterioscler, Thromb Vasc Biol, 1999, 19(9): 2241-2244.
15.	Page MK, Bukki J, Luppa P, et al. Clinical value of cystatin C determination [J]. Clinica Chimica Acta, 2000, 297(1-2): 67-72.

1. Shi GP, Sukhova GK, Grubb A, et al. Cystatin C in human atherosclerosis and aortic aneurysms[J]. J Clin Invest, 1999, 104(9): 1191-1197.
2. Yetkin E, Acikqoz N, Sivri N, et al. Increased plasma levels of cystatin C and transforming growth factor-beta1 in patients with coronary artery ectasia: can there be a potential interaction between cystatin C and transforming growth factor-factor-beta1[J]. Coron Artery Dis, 2007, 18(3): 211-214.
3. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis [J]. Science, 1986, 232(4746): 34-47.
4. Toshima S, Hasegawa A, Kurabayashi M, et al. Circulating oxidized low density lipoprotein: a biochemical risk marker for coronary heart disease[J]. Arterioscler Thromb Vasc Biol, 2000, 20: 2243-2247.
5. Report of expert committee on the diagonsis and classification of diabetes mellitus[J]. Diabetes Care, 2002, 25(Suppl 1): 5-20.
6. 中国高血压防治指南修订委员会. 中国高血压防治指南(2005年修订版)[J]. 高血压杂志, 2005, 13(增刊): 241.
7. Uzun H, Ozmen Keles M, Ataman R, et al. Serum cystatin C level as a potentially good marker for impaired kidney function[J]. Clin Biochem, 2005, 38(9): 792-798.
8. Galteau MM, Guyon M, Gueguen R, et al. Determination of serum cystatinC: biological variation and reference values[J]. Clin Chem Lab Med, 2001, 39(9): 850-857.
9. Wilson PW, D’Agostino RB, Levy Daniel, et al. Prediction of Coronary Heart Disease Using Risk Factor Categories[J]. Circulation, 1998, 97(18): 1837-1847.
10. Luc G, Bard J, Lesueur C, et al. Plasma cystatin-C and development of coronary heart disease: The PRIME Study[J]. Atherosclerosis, 185(2): 375-380.
11. Ross R. Atherosclerosis-an inflammatory disease[J]. N Engl J Med, 1999, 340: 115-126.
12. Randers E, Erlandsen EJ. Serum cystatin C as an endogenous marker of the renal function: a riview[J]. Clin Chem Lab Med, 37(4): 389-395.
13. Dickinson DP, Zhao Y, Thiesse M, et al. Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11. 2[J]. Genomis, 1994, 24(1): 172-175.
14. Bostom AG, Bausserman L, Jacques PF, et al. Cystatin C as a determinant of fasting plasma total homocysteine levels in coronary artery disease patients with normal serum creatinine[J]. Arterioscler, Thromb Vasc Biol, 1999, 19(9): 2241-2244.
15. Page MK, Bukki J, Luppa P, et al. Clinical value of cystatin C determination [J]. Clinica Chimica Acta, 2000, 297(1-2): 67-72.

West China Medical Journal

Association Between Serum Cystatin C Concentration and Lipid, Hs-C Reactive Protein in the Elderly with Diabetes

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