A Screening Study on Premature Infants with Retinopathy of Prematurity_West China Medical Journal

Authors：

1. Department of Ophthalmology, Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P.R.China; 2. Department of Ophthalmology, Nanchong Central Hospital, Nanchong, Sichuan 637000, P.R.China;

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Keywords：

早产儿视网膜病变; 出生时低体重; 小胎龄; 发病率; 危险因素

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【摘要】目的 探讨早产儿视网膜病变（retinopathy of prematurity，ROP）的发生率及危险因素。方法收集2007年12月-2008年12月在四川省人民医院、成都市妇幼保健院、成都市妇产科医院住院的85例体重≤2 000 g或有严重疾病的早产儿,自出生后4~6周或矫正胎龄32周开始筛查，至周边视网膜血管化。结果 85例早产儿中，有9例发生ROP，发病率10.58%。其中出生体重 lt;1 500 g的早产儿ROP发病率为17.07%，孕周 lt;30周的早产儿ROP发病率为40%。结论低体重、胎龄小、吸氧为早产儿发生ROP的重要危险因素；尽早进行眼底筛查是早期发现、诊断及治疗ROP的关键。
【Abstract】 Objective To investigate the occurrence and risk factors of retinopathy of prematurity (ROP). Methods A total of 85 premature infants were enrolled from Sichuan provincial people′s hospital, Chengdu maternal and child health hospital, and Chengdu obstetric and gynecology hospital. The infants were born between December 2007 and December 2008, with a birth weight less than 2 000 g. The ocular funds examination was carried out four to six weeks after the birth or at the 32nd week of the corrected gestational age;the infants were followed up until the retina was entirely vascularized. Results ROP was found in 9 of the 85 premature infants, with a percentage of 10.58%. About 17.07% premature infants with a birth weight less than 1500 g and 40% infants with a gestational age shorter than 30 weeks had ROP. Conclusions A lower birth weight, a shorter gestational age and oxygen usage are the risk factors of ROP. It′s important to examine the ocular fundus in premature infants as early as possible so as to identify, diagnose and treat ROP at an early stage.

Citation： ZHONG Jie,LIU Sanmei,TANG Jing,FAN Yingchuan. A Screening Study on Premature Infants with Retinopathy of Prematurity. West China Medical Journal, 2010, 25(9): 1659-1661. doi: Copy

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1. and high levels of development: implications for screening programs[J]. Pediatrics, 2005, 115(5): 518-522.
2. Gilbert C, Foster A. Childhood blindness in the context of Vision 2020-the right to sight. Bull WHO, 2001, 79(3): 227-232.
3. Forbes BJ, Khazaeni LM. Evaluation and management of a prematur infant′s eyes[J]. Pediatr Case Reviews, 2003, 3(2): 105-110.
4. 中华人民共和国卫生部. 早产儿治疗用氧和视网膜病变防治指南[S]. 2004.
5. The Committee for the Classification of Retinopathy of Prematurity. An international classification of retinopathy of prematurity[J]. Arch Ophthalmol, 1984, 102(8): 1130-1134.
6. Hussain N, Clive J, Bhandari V. Current incidence of retinopathy Of prematurity, 1989-1997 [J]. Pediatrics, 1999, 104 (3): 26-34.
7. Gilbert C, Fielder A, Gordillo L, et al. Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate,.
8. Smith LE. Pathogenesis of retinopathy of prematurity[J]. Acta Paediatr Suppl, 2002, 91(437): 26-28.
9. Noyola DE, Bohra L, Paysse EA, et al. Association of Candidemia and retinopathy of prematurity in very low birthweighy in infants[J]. Ophthamology, 2002, 109(1): 80-84.
10. Procianoy RS, Gancia_Prats JA, Hittner HM, et al. An Association between retinopathy of prematurity and intraventricular hemorrhage in very low weight infants[J]. Acta Paediater Scand, 1981, 70(4): 473-477.
11. Martín BN, Perapoch LJ. Retinopathy of prematurity: incidence, severity and outcome[J]. An Pediatr (Barc), 2003, 58(2): 156-161.
12. Palmer EA, Flynn JT, Hardy RJ, et al. Incidence and early course of retinopathy of prematurity[J]. Ophthalmology, 1991, 98(11): 1628-1638.
13. American Academy of Pediatrics. Section on Ophthalmology. Screening examination of premature infants for retinopathy of prematurity[J]. Pediatrics, 2001, 108(3): 809-811.

West China Medical Journal

A Screening Study on Premature Infants with Retinopathy of Prematurity

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