【摘要】 目的  观察曲马多超前镇痛对经腹子宫切除术患者术后疼痛和恶心呕吐的影响。 方法  2008年11月-2009年5月，40例全身麻醉下行经腹子宫切除术的患者，分为超前镇痛组和对照组（n=20）。超前镇痛组和对照组于麻醉诱导前30 min分别静脉注射曲马多（3 mg/kg）和生理盐水。术后12、24 h，观察Bolus次数和芬太尼的用量，患者疼痛评分及术后恶心呕吐的发生率。 结果  术后12、24 h，曲马多超前镇痛组Bolus次数和芬太尼的用量均小于对照组（P lt;0.05），术后恶心呕吐的发生率差异无统计学意义（P gt;0.05）。 结论  经腹子宫切除术手术前给予曲马多超前镇痛能够减少术后镇痛药的需要量，且不增加术后恶心呕吐的发生率。
【Abstract】 Objective  To observe the effects of tramadonl preemptive analgesia on postoperative pain and postoperative nausea and vomiting (PONV) in patients with hysterectomy. Methods  Form November 2008 to May 2009, fourty patients who had undergone hysterectomy were divided into preemptive analgesia (PA) group and control group, 20 patients in each. The PA and control group were intravenously injected with tramadol (3 mg/kg) and normal saline respectively. Twelve and 24 hours after hysterectomy, the Bolus times, consumption of fentanil, pain score and incidence of PONV were observed. Results  Twelve and 24 hours after hysterectomy, the Bolus times and consumption of fentanil were both lower than those in control group(P lt;0.05), the difference of PONV incidences between two groups was not statistically significant (P gt;0.05). Conclusion  Intravenously injected with tramadol before hysterectomy can recduce the dosage of analgesic, and don′t increase the incidence of PONV.

Citation： YANG Chang. Effects of Tramadonl Preemptive Analgesia on Postoperative Pain,Nausea and Vomiting in Patients with Hysterectomy. West China Medical Journal, 2010, 25(9): 1704-1705. doi: Copy