【摘要】 目的  研究不同压力二氧化碳（CO2）气腹对糖代谢的影响。 方法  18只雌性健康新西兰大白兔按CO2气腹压力随机均分为气腹压0 mm Hg （1 mm Hg=0.133 kPa）（Ⅰ组）、气腹压10 mm Hg（Ⅱ组）和气腹压15 mm Hg（Ⅲ组）。每组兔均在不同的压力下接受气腹1 h。在CO2气腹前（T0）、气腹后30 min （T1）、气腹后60 min （T2） 测定动脉血气分析值、血糖（Glu）、胰岛素（Ins）和胰高糖素（Gln）。 结果  气腹后30 min 、60 min，Ⅱ组与Ⅰ组比较，PaCO2、Glu 、Gln增加（P lt;0.05），pH值和Ins下降（P lt;0.05），Ⅲ组各参数变化更为显著（P lt;0.01）。结论 CO2气腹后机体可能处于较强烈的应激状态，导致血糖升高。
【Abstract】 Objective  To study effects of different intraabdominal pressure of carbon dioxide (CO2) pneumoperitoneum on blood glucose level in rabbits. Methods  Eighteen female healthy rabbits weighed 2.1-3.3 kg were randomly divided into three groups equally based on pneumoperitoneum pressure: 0 mm Hg (1 mm Hg=0.133 kPa) group (groupⅠ),10 mm Hg group (groupⅡ) and 15 mm Hg (groupⅢ). Each group received 1h pneumoperitoneum under diffent pressure. Blood samples were taken before CO2 pneumoperitoneum, at 30 and 60 minutes after pneumoperitoneum for the measure-ments of arterial blood gas, blood glucose (Glu), insulin (Ins) and glucone (Gln). Results  After pneumoperitoneum at 30 and 60 minutes, compared with groupⅠ, PaCO2,Glu and Gln were significantly raised in groupⅡ(P lt;0.05), pH and Ins were markedly decreased (P lt;0.05). Even more significant changes were observed in group Ⅲ(P lt;0.01). Conclusion  After CO2 pneumoperitoneum, body is in a relatively b stress, so blood glucose is decreased.

Citation： YE Zhanyong,LI Jun,LIU Henian,GONG Gu,BAI Shurong,HOU Jingli. Effects of Different Intra-abdominal Pressure of Carbon Dioxide Pneumoperito-neum on Blood Glucose Level. West China Medical Journal, 2010, 25(9): 1706-1707. doi: Copy