Effects of Bacterial Collagenase on Wound Infection via Blind Means_West China Medical Journal

Authors：

QIU Li ¹ , HE Qing ²

1. Emergency Department of Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R.China; 2. Emergency Department of West China Center of Medical of Sichuan University, Chengdu 610044, P. R.China;

Corresponding author：

Keywords：

细菌性胶原酶; 创伤感染; 炎性细胞; 盲法

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【摘要】目的 探讨细菌性胶原酶对创口感染情况的影响。方法 2006年11月-2006年12月，对28只新西兰兔分为实验组和对照组，分别予细菌性胶原酶溶液及生理盐水浸润创口并缝合。观察创口感染及局部皮肤的炎性细胞浸润情况。结果实验组与对照组创口感染率差别无统计学意（P gt;0.05），炎性细胞差别无统计学意义（P gt;0.05）。结论细菌性胶原酶在创伤修复过程中不能直接降低感染率，对炎性细胞的迁移并无明显的作用。 
【Abstract】 Objective To assess the effects of bacterial collagenase on the wound infection. Methods A total of 28 New Zealand rabbits have chosen from November to December 2006, and were divided into a laboratorial group and a control group. We sutured the wounds and soaked them by the bacterial collagenase liquid or by the physiologic saline solution. The infection and the inflammatory cells of the skin around the wound were observed. Results The difference of the infection rates between the two groups was not statistically significant (P=0.62), nor the difference of inflammatory cells (P=0.84). Conclusions Bacterial collagenase can not decrease the rate of infection directly, and had no obvious effect on the transferring of inflammatory cells.

Citation： QIU Li,HE Qing. Effects of Bacterial Collagenase on Wound Infection via Blind Means. West China Medical Journal, 2010, 25(10): 1815-1816. doi: Copy

1.	Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study[J]. Burn Care Rehabil, 1994, 15(1): 13-17.
2.	Ozcan C, Ergun O. Emzymatic debridement of burn wound with collagenase in children with partial-thickness burns[J]. Burns, 2002, 28, (8): 791-794.
3.	Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement[J]. Wound Ostomy Continence Nurs. 2009, 36(6): 12-16.
4.	Ermertcan AT, Inan S, Ozturkcan S, et al. Cilaker Scomparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study[J]. 2008, 16(5): 674-681.
5.	曲滨, 邵铁滨, 杨心波, 等. 梭状芽孢杆菌胶原酶治疗深Ⅱ度烧伤的临床观察[J]. 黑龙江医学, 2003, 27(8): 590.
6.	Riley KN, Herman IM. Collagenase promotes the cellular responses toinjury and wound hea-ling in vivo[J]. Burns Wounds, 2005, 17(4): 8.
7.	Eldad A, Weinberg A, Beiterman S, et al. Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns[J]. Burn, 1998, 24(2): 166-172.
8.	程飚, 付小兵, 盛志勇, 等. 碱性成纤维细胞生长因子对大鼠烫伤创面中基质金属蛋白及其抑制剂的影响[J]. 中华烧伤杂志, 2003, 19(6): 336-339.
9.	王世岭, 李利根, 周亮, 等. 胶原酶对小面积深度烧伤创面清创效果分析[J]. 中国临床药理学杂志, 2000, 16(1): 18-21.
10.	李孝建, 刘锡麟, 霍丽贞. 爱疗素软膏对深度烧伤创面的疗效观察[J]. 广东药学报, 2000, 16(1): 65-66.
11.	杨红明, 柴家科, 郭振荣, 等. 创面用药变革对深Ⅱ度烧伤创面愈合时间的影响[J]. 中国修复重建外科杂志, 2001, 15(3): 162-164.
12.	王配合, 齐顺贞, 彭毅志. 爱疗素软膏对深Ⅱ度烧伤创面的疗效观察[J]. 华北国防医药, 2004, 16(1): 10-12.

1. Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study[J]. Burn Care Rehabil, 1994, 15(1): 13-17.
2. Ozcan C, Ergun O. Emzymatic debridement of burn wound with collagenase in children with partial-thickness burns[J]. Burns, 2002, 28, (8): 791-794.
3. Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement[J]. Wound Ostomy Continence Nurs. 2009, 36(6): 12-16.
4. Ermertcan AT, Inan S, Ozturkcan S, et al. Cilaker Scomparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study[J]. 2008, 16(5): 674-681.
5. 曲滨, 邵铁滨, 杨心波, 等. 梭状芽孢杆菌胶原酶治疗深Ⅱ度烧伤的临床观察[J]. 黑龙江医学, 2003, 27(8): 590.
6. Riley KN, Herman IM. Collagenase promotes the cellular responses toinjury and wound hea-ling in vivo[J]. Burns Wounds, 2005, 17(4): 8.
7. Eldad A, Weinberg A, Beiterman S, et al. Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns[J]. Burn, 1998, 24(2): 166-172.
8. 程飚, 付小兵, 盛志勇, 等. 碱性成纤维细胞生长因子对大鼠烫伤创面中基质金属蛋白及其抑制剂的影响[J]. 中华烧伤杂志, 2003, 19(6): 336-339.
9. 王世岭, 李利根, 周亮, 等. 胶原酶对小面积深度烧伤创面清创效果分析[J]. 中国临床药理学杂志, 2000, 16(1): 18-21.
10. 李孝建, 刘锡麟, 霍丽贞. 爱疗素软膏对深度烧伤创面的疗效观察[J]. 广东药学报, 2000, 16(1): 65-66.
11. 杨红明, 柴家科, 郭振荣, 等. 创面用药变革对深Ⅱ度烧伤创面愈合时间的影响[J]. 中国修复重建外科杂志, 2001, 15(3): 162-164.
12. 王配合, 齐顺贞, 彭毅志. 爱疗素软膏对深Ⅱ度烧伤创面的疗效观察[J]. 华北国防医药, 2004, 16(1): 10-12.

West China Medical Journal

Effects of Bacterial Collagenase on Wound Infection via Blind Means

Abstract Full text Figures/Tables Video References Cited by

Format

Content