【摘要】 目的 探讨肌萎缩性侧索硬化（amyotrophic lateral sclerosis，ALS）的临床特点和诊断。 方法 分析2005年1月-2009年1月收治的57例ALS患者，对其临床特点进行统计分析。 结果 ALS以50～60年龄段发病为主，男性多见。患者平均发病年龄52岁，男女发病年龄无差别，男女比例1.7∶1，死亡23例（40.4%），平均生存时间22个月。 结论 发病年龄越晚，病后存活时间越短。临床表现隐袭起病，逐渐进展。其诊断主要依据临床表现，肌电图检查对早期诊断有重要的价值。
【Abstract】 Objective To analyze clinical features and diagnosis of patients with ALS. Methods Fifty-seven patients with ALS were consecutively followed up, and their clinical characteristics were collected from January 2005 to January 2009. Results The average age of onset of patients with ALS was about 50-60 years, and the male was predominant. The mean age of onset was 52 years, and there was no significant difference in the mean age of onset regarding to gender. The ratio of male and female was 1.7. Twenty-three patients (40.4%) died during the period of follow-up, and the mean disease duration was 22 months. Conclusion The older the onsetage is, the more rapid the progression of the disease and shorter the survival time ane. ALS is characterized by onset slowly and progressive muscular paralysis. The diagnosis is primarily based on clinical characteristics, and electromyography examin7ation in early diagnosis has important value.
Citation： QING Shaohua,FANG Dengfu,ZENG Yan. Clinical Analysis of Patients with Amyotrophic Lateral Sclerosis. West China Medical Journal, 2010, 25(11): 2009-2011. doi: Copy