曲美他嗪治疗缺血性扩张型心肌病疗效观察_West China Medical Journal

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任静 , 冯胜红

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曲美他嗪; 扩张型心肌病

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【摘要】　目的　总结曲美他嗪在缺血性扩张型心肌病患者心功能改善方面的作用。　方法　 2007年1月-2009年12月随机将61例患者分为二组，观察组给予常规药物治疗加用曲美他嗪，对照组给予常规治疗，通过心功能及左心室射血分数两个方面来评估治疗效果。　结果　观察组较对照组显著增加左室射血分数，并能改善患者心功能分级。　结论　缺血性扩张型心肌病患者可以很好地耐受较长期的曲美他嗪治疗，同时心功能也得到改善。

Citation： 任静,冯胜红. 曲美他嗪治疗缺血性扩张型心肌病疗效观察. West China Medical Journal, 2010, 25(11): 2060-2061. doi: Copy

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1. 　Di Napoli P, Taccardi AA, Bardotti A. Long term cardio-protective action of trimetazidine and potential effect on the inflammatory process in patients with ischemic dilated cardiomyopathy[J]. Heart, 2005, 92(2): 161-165.
2. 　贾三庆, 董晓冬, 胡大一, 等. 曲美他嗪心肌细胞保护作用的临床研究[J]. 中华心血管病杂志, 2003, 31(增刊): 201-208.
3. 　Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischmic cardiomyopathy[J]. Eur Heart J, 2001, 22(23): 2164-2170.
4. 　谢瑞芹, 都军, 郝玉明, 等. 曲美他嗪治疗冠心病心力衰竭疗效观察[J]. 中华心血管病杂志, 2004, 32(1): 77.
5. 　胡大一, 赵秀丽. 曲美他嗪对稳定性劳力型心绞痛的疗效观察[J]. 中华心血管病杂志, 2000, 29(15): 18-20.
6. 　Guarnieri C, Muscari C. Effict of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischmic hypertrophied myocardium[J]. Pharmacology, 1993, 46: 324-331.
7. 　Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischmic cardiomyopathy[J]. Eur Heart J, 2001, 22: 2164-2170.
8. 　Lu C, Dabrowski P, Fracasso G, et al. Effects of trimetazidine on ischmic left ventricular dysfunction in patients with coronary disease: a doubleblind. Placebo-controlled, crossover study[J]. Am J Cardiol, 1998, 82: 898-901.

West China Medical Journal

曲美他嗪治疗缺血性扩张型心肌病疗效观察

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