免疫功能紊乱相关的获得性单纯性红细胞再生障碍性贫血_West China Medical Journal

Authors：

邝璞 ,  刘霆

Corresponding author：

刘霆, Email: kwangpu@gmail.com

Keywords：

单纯性红细胞再生障碍性贫血; 体液免疫; 细胞免疫; 发病机制

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【摘要】　单纯性红细胞再生障碍性贫血（pure red cell aplasia， PRCA）是临床相对罕见的一组异质性疾病，其中获得性PRCA发病原因多种多样。现就各种背景疾病下，免疫功能紊乱在PRCA发病机制中的作用进行探讨。

Citation： 邝璞,刘霆. 免疫功能紊乱相关的获得性单纯性红细胞再生障碍性贫血. West China Medical Journal, 2010, 25(11): 2111-2113. doi: Copy

1.	Lacy MQ, Kurtin PJ, Tefferi A. Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities[J]. Blood, 1996, 87(7): 3000-3006.
2.	Murakawa T, Nakajima J, Sato H, et al. Thymoma associated with pure red-cell aplasia: clinical features and prognosis[J]. Asian Cardiovasc Thorac Ann, 2002, 10(2): 150-154.
3.	Greer JP, Foerster J, Lukens JN, et al. Wintrobe′s Clinical Hematology[M]. 11th ed. Philadelphia: Lippincott Williams & Wilkins, 2004: 331-333.
4.	Fujisao S, Tsuda H. Th1/Th2 balance alteration in the clinical course of a patient with pure red cell aplasia and thymoma[J]. Br J Haematol, 1998, 103(2): 308-310.
5.	Masuda M, Arai Y, Okamura T, et al. Pure red cell aplasia with thymona: evidence of T-cell clonal disorder[J]. Am J Hematol, 1997, 54(4): 324-328.
6.	Mamiya S, Itoh T, Miura AB. Acquired pure red cell aplasia in Japan[J]. Eur J Haematol, 1997, 59(4): 199-205.
7.	Go RS, Li CY, Tefferi A, et al. Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes[J]. Blood, 2001, 98(2): 483-485.
8.	Kawahara S, Sasaki M, Isobe Y, et al. Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in Japan[J]. Eur J Haematol, 2009, 82(4): 308-314.
9.	Loughran TP, Jr. Clonal diseases of large granular lymphocytes[J]. Blood, 1993, 82(1): 1-14.
10.	Castelli R, Vismara A, Pavia G, et al. Relapsing pure red cell aplasia associated with B-cell chronic lymphocytic leukemia successfully treated by intravenous immunoglobulin concentrate[J]. Ann Ital Med Int, 2002, 17(1): 47-50.
11.	D′Arena G, Vigliotti ML, Dell′Olio M, et al. Rituximab to treat chronic lymphoproliferative disorder-associated pure red cell aplasia[J]. Eur J Haematol, 2009, 82(3): 235-239.
12.	Dungarwalla M, Marsh JC, Tooze JA, et al. Lack of clinical efficacy of rituximab in the treatment of autoimmune neutropenia and pure red cell aplasia: implications for their pathophysiology[J]. Ann Hematol, 2007, 86(3): 191-197.
13.	Thachil J, Salim R. Campath-1H induced pure red cell aplasia in a patient with chronic lymphatic leukaemia[J]. Leuk Res, 2007, 31(7): 1025-1026.
14.	Casadevall N, Nataf J, Viron B, et al. Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin[J]. N Engl J Med, 2002, 346(7): 469-475.
15.	Boven K, Stryker S, Knight J, et al. The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes[J]. Kidney International, 2005, 67(6): 2346-2353.
16.	Means RT, Dessypris EN, Krantz SB. Treatment of refractory pure red cell aplasia with cyclosporine A: disappearance of IgG inhibitor associated with clinical response[J]. Br J Haematol, 1991, 78(1): 114-119.
17.	Bai LY, Liu JH, Kau JP. T-cell clonal disorder in acquired primary pure red cell aplasia[J]. Ann Hematol, 2004, 83(8): 544-546.
18.	Masuda M, Teramura M, Matsuda A, et al. Clonal T cells of pure red-cell aplasia[J]. Am J Hematol, 2005, 79(4): 332-333.
19.	Yamada O. Clonal T cell proliferation in patients with pure red cell aplasia[J]. Leuk Lymphoma, 1999, 35(1-2): 69-82.
20.	Handgretinger R, Geiselhart A, Moris A, et al. Pure red-cell aplasia associated with clonal expansion of granular lymphocytes expressing killer-cell inhibitory receptors[J]. N Engl J Med, 1999, 340(4): 278-284.
21.	Bigouret V, Hoffmann T, Arlettaz L, et al. Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94: NKG2C/E and NKD2D killer cell receptors[J]. Blood, 2003, 101(8): 3198-3204.
22.	Sivakumaran M, Bhavnani M, Stewart A, et al. Is pure red cell aplasia (PRCA) a clonal disorder?[J]. Clin Lab Haematol, 1993, 15(1): 1-5.
23.	Nadeau L, Meyerson H, Warren G, et al. A sustained response to low dose interferon-alpha in a case of refractory pure red cell aplasia[J]. Eur J Haematol, 2004, 73(4): 300-303.
24.	Sawada K, Hirokawa M, Fujishima N, et al. Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group[J]. Haematologica, 2007, 92(8): 1021-1028.
25.	Charles RJ, Sabo KM, Kidd PG, et al. The pathophysiology of pure red cell aplasia: implications for therapy[J]. Blood, 1996, 87(11): 4831-4838.

1. 　Lacy MQ, Kurtin PJ, Tefferi A. Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities[J]. Blood, 1996, 87(7): 3000-3006.
2. 　Murakawa T, Nakajima J, Sato H, et al. Thymoma associated with pure red-cell aplasia: clinical features and prognosis[J]. Asian Cardiovasc Thorac Ann, 2002, 10(2): 150-154.
3. 　Greer JP, Foerster J, Lukens JN, et al. Wintrobe′s Clinical Hematology[M]. 11th ed. Philadelphia: Lippincott Williams & Wilkins, 2004: 331-333.
4. 　Fujisao S, Tsuda H. Th1/Th2 balance alteration in the clinical course of a patient with pure red cell aplasia and thymoma[J]. Br J Haematol, 1998, 103(2): 308-310.
5. 　Masuda M, Arai Y, Okamura T, et al. Pure red cell aplasia with thymona: evidence of T-cell clonal disorder[J]. Am J Hematol, 1997, 54(4): 324-328.
6. 　Mamiya S, Itoh T, Miura AB. Acquired pure red cell aplasia in Japan[J]. Eur J Haematol, 1997, 59(4): 199-205.
7. 　Go RS, Li CY, Tefferi A, et al. Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes[J]. Blood, 2001, 98(2): 483-485.
8. 　Kawahara S, Sasaki M, Isobe Y, et al. Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in Japan[J]. Eur J Haematol, 2009, 82(4): 308-314.
9. 　Loughran TP, Jr. Clonal diseases of large granular lymphocytes[J]. Blood, 1993, 82(1): 1-14.
10. 　Castelli R, Vismara A, Pavia G, et al. Relapsing pure red cell aplasia associated with B-cell chronic lymphocytic leukemia successfully treated by intravenous immunoglobulin concentrate[J]. Ann Ital Med Int, 2002, 17(1): 47-50.
11. 　D′Arena G, Vigliotti ML, Dell′Olio M, et al. Rituximab to treat chronic lymphoproliferative disorder-associated pure red cell aplasia[J]. Eur J Haematol, 2009, 82(3): 235-239.
12. 　Dungarwalla M, Marsh JC, Tooze JA, et al. Lack of clinical efficacy of rituximab in the treatment of autoimmune neutropenia and pure red cell aplasia: implications for their pathophysiology[J]. Ann Hematol, 2007, 86(3): 191-197.
13. 　Thachil J, Salim R. Campath-1H induced pure red cell aplasia in a patient with chronic lymphatic leukaemia[J]. Leuk Res, 2007, 31(7): 1025-1026.
14. 　Casadevall N, Nataf J, Viron B, et al. Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin[J]. N Engl J Med, 2002, 346(7): 469-475.
15. 　Boven K, Stryker S, Knight J, et al. The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes[J]. Kidney International, 2005, 67(6): 2346-2353.
16. 　Means RT, Dessypris EN, Krantz SB. Treatment of refractory pure red cell aplasia with cyclosporine A: disappearance of IgG inhibitor associated with clinical response[J]. Br J Haematol, 1991, 78(1): 114-119.
17. 　Bai LY, Liu JH, Kau JP. T-cell clonal disorder in acquired primary pure red cell aplasia[J]. Ann Hematol, 2004, 83(8): 544-546.
18. 　Masuda M, Teramura M, Matsuda A, et al. Clonal T cells of pure red-cell aplasia[J]. Am J Hematol, 2005, 79(4): 332-333.
19. 　Yamada O. Clonal T cell proliferation in patients with pure red cell aplasia[J]. Leuk Lymphoma, 1999, 35(1-2): 69-82.
20. 　Handgretinger R, Geiselhart A, Moris A, et al. Pure red-cell aplasia associated with clonal expansion of granular lymphocytes expressing killer-cell inhibitory receptors[J]. N Engl J Med, 1999, 340(4): 278-284.
21. 　Bigouret V, Hoffmann T, Arlettaz L, et al. Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94: NKG2C/E and NKD2D killer cell receptors[J]. Blood, 2003, 101(8): 3198-3204.
22. 　Sivakumaran M, Bhavnani M, Stewart A, et al. Is pure red cell aplasia (PRCA) a clonal disorder?[J]. Clin Lab Haematol, 1993, 15(1): 1-5.
23. 　Nadeau L, Meyerson H, Warren G, et al. A sustained response to low dose interferon-alpha in a case of refractory pure red cell aplasia[J]. Eur J Haematol, 2004, 73(4): 300-303.
24. 　Sawada K, Hirokawa M, Fujishima N, et al. Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group[J]. Haematologica, 2007, 92(8): 1021-1028.
25. 　Charles RJ, Sabo KM, Kidd PG, et al. The pathophysiology of pure red cell aplasia: implications for therapy[J]. Blood, 1996, 87(11): 4831-4838.

West China Medical Journal

免疫功能紊乱相关的获得性单纯性红细胞再生障碍性贫血

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