目的:回顾性分析不同年龄组IgA肾病患者的病理改变特点,以利于早期诊断和治疗。方法:将我院280例(2005~2007年)经皮肾活检确诊为原发性IgA肾病的患者按不同年龄分为儿童组、青少年组和成人组,逐项分析病例组织光镜和免疫荧光检查的相关资料。结果:在280例病理资料中,儿童组患者病理学分级以Ⅰ~Ⅱ级为主,免疫荧光检查以单纯IgA 和或C3沉积多见;青少年组患者病理学分级以Ⅰ~Ⅲ级为主,免疫荧光检查也是以单纯IgA 和或C3 沉积多见;成人组病理学改变从Ⅰ~Ⅳ级均可见到,主要以Ⅲ ~Ⅳ级为主,免疫荧光检查以单纯IgA 、IgA + IgM和或C3沉积较多。结论:IgA肾病的病理改变有随着年龄增大,病理改变越明显肾脏损害越严重的趋势,早期进行经皮肾活检有利于明确诊断及尽早治疗。
Citation:
MA Yunxia,MA Xingyi,MI Xuhua,et al. Pathological Analysis of 280 Cases with Dfferent Age-Groy IgA Nephropathy. West China Medical Journal, 2009, 24(2): 310-312. doi:
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- 1. Donadio JV,Grande JP.IgA nephropathy[J].N Engl J Med,2002,347:738- 748..
- 2. Churg J,Sobin LH.Renal Disease Classification and atlas of glomerular disease[M].Tokyo:Ikagu:Shoin medical publishers Inc,1982:4..
- 3. Churg J,Bernstein J,Glassock RJ.Renal Disease -Classification and atlas of glomerular disease.Second edition[M].New York:Ikagu- Shoin medical publishers Inc,1995:4..
- 4. Donadio JV,Grande JP.IgA nephropathy[J].N Engl J Med,2002,347:738-48..
- 5. Li LS,Liu ZH.Epidemiologic data of renal diseases from a single unit in China:analysis based on 13,519 renal biopsies[J].Kideny Int,2004,66:920-923..
- 6. 刘刚,马序竹,邹万忠,等.肾活检患者肾脏病构成十年对比分析[J].临床内科杂志,2004,12:45-49.