Clinical and Bactend Resister mdysis of 107 stochits Acinetobacter Baumannii_West China Medical Journal

Authors：

DU Rong , FENG Ping , CHEN Huili , et al.

Center of Infectious Disease，West China Hospital，Sichuan University，Chengdu 610041，China;

Corresponding author：

Keywords：

鲍曼不动杆菌; 琼脂对倍稀释法; 耐药率

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目的：对鲍曼不动杆菌感染的临床特征和耐药性进行分析，为临床诊治提供参考。方法：对2005年1月～2006年6月我院临床分离的共107株鲍曼不动杆菌通过琼脂对倍稀释法进行MIC测定；同时对相应的临床病例进行回顾性分析。结果：107株鲍曼不动杆菌大多分离自痰液，主要来自于ICU病房；且91.59%的患者同时存在2种以上基础疾病。鲍曼不动杆菌对氨曲南耐药率最高，为89.72%，依次是头孢西丁(87.85%)，头孢哌酮(76.64%)、哌拉西林(69.16%)、头孢噻肟(65.42%)、环丙沙星(65.42%)、阿米卡星(56.07%)、头孢他定(5514%)等。结论：我院鲍曼不动杆菌耐药情况严重，治疗首选碳青霉烯类抗生素，其次可选用头孢吡肟、头孢哌酮/舒巴坦。

Citation： DU Rong,FENG Ping,CHEN Huili,et al.. Clinical and Bactend Resister mdysis of 107 stochits Acinetobacter Baumannii. West China Medical Journal, 2009, 24(2): 339-341. doi: Copy

1.	Clinial and Laboratory Standards Institute(CLSI)/NCCLS.Performance Standards for Antimocrobial Susceptibity testing Standards：Fifteenth Informational Supplement[S].2005，M100S15..
2.	Ronald N，Jones AB，Helio S.Contemporary in vitro spectrum of activity summary forantimicrobial agents tested against 18 569 strains nonfermentative Gramnegative bacilli isolated in the SENTRY Antimicrobial Surveillance Program(19972001)[J].International J Antimicrob Agents，2003，22：551-6..
3.	陈民均，王辉.中国重症监护病房革兰阴性菌耐药性连续7年监测研究[M].中国医院内病原菌耐药监测网，2003年5月12日..
4.	Tao CM，Chen HL，Liu YG，et al.Analisis on antibiotics resistance of nonfermenting gramnegative bacilli isolated from our hospital during 1998 and 2005[J].Chin J Infect Chemothr，2006，6：399-402..
5.	DallaCosta LM，Coelho JM，Souza HA，et al.Outbreak of carbapenemresistant Acinetobacter baumannii producing the OXA23 enzyme in Curitiba，Brazil[J].J Clin Microbiol，2003，41：3403-6..
6.	Heritier C，Dubouix A，Poirel L，et al.A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenemhydrolysing oxacillinase OXA58[J].J Antimicrob Chemother，2005，55：115-8..
7.	Gehrlein M，Leying H，Cullmann W，et al.Imipenem resistance in Acinetobacter baumannii is due to altered penicillinbinding proteins[J].Chemother，1991，37：405-12..
8.	Limansky AS，Mussi MA，Viale AM.Loss of a 29kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance[J].J Clin Microbiol，2002，40：4776-8..

1. Clinial and Laboratory Standards Institute(CLSI)/NCCLS.Performance Standards for Antimocrobial Susceptibity testing Standards：Fifteenth Informational Supplement[S].2005，M100S15..
2. Ronald N，Jones AB，Helio S.Contemporary in vitro spectrum of activity summary forantimicrobial agents tested against 18 569 strains nonfermentative Gramnegative bacilli isolated in the SENTRY Antimicrobial Surveillance Program(19972001)[J].International J Antimicrob Agents，2003，22：551-6..
3. 陈民均，王辉.中国重症监护病房革兰阴性菌耐药性连续7年监测研究[M].中国医院内病原菌耐药监测网，2003年5月12日..
4. Tao CM，Chen HL，Liu YG，et al.Analisis on antibiotics resistance of nonfermenting gramnegative bacilli isolated from our hospital during 1998 and 2005[J].Chin J Infect Chemothr，2006，6：399-402..
5. DallaCosta LM，Coelho JM，Souza HA，et al.Outbreak of carbapenemresistant Acinetobacter baumannii producing the OXA23 enzyme in Curitiba，Brazil[J].J Clin Microbiol，2003，41：3403-6..
6. Heritier C，Dubouix A，Poirel L，et al.A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenemhydrolysing oxacillinase OXA58[J].J Antimicrob Chemother，2005，55：115-8..
7. Gehrlein M，Leying H，Cullmann W，et al.Imipenem resistance in Acinetobacter baumannii is due to altered penicillinbinding proteins[J].Chemother，1991，37：405-12..
8. Limansky AS，Mussi MA，Viale AM.Loss of a 29kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance[J].J Clin Microbiol，2002，40：4776-8..

West China Medical Journal

Clinical and Bactend Resister mdysis of 107 stochits Acinetobacter Baumannii

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