The Diagnosis and Treatment of Parathyroid Carcinoma_West China Medical Journal

Authors：

ZHOU Yang , GONG Rixiang , LUO Shuhua , et al.

Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;

Corresponding author：

Keywords：

甲状旁腺癌; 诊断; 治疗

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:总结和探讨甲状旁腺癌的诊断和治疗方法。方法:回顾性总结本院5例甲状旁腺癌的临床资料。结果:5例患者术前颈部均扪及质硬包块,平均血钙浓度为3.82 mmol/L,平均PTH浓度为153.6 pmol/L,4例术中发现周围浸润表现。5例中4例同时行甲状旁腺肿瘤和同侧甲状腺腺叶切除,1例仅行甲状旁腺肿瘤切除。5例术后均诊断为甲状旁腺癌。术后4例得到随访,时间4月～5年。其中2例术后无复发;1例于术后半年局部复发行患侧甲状腺切除,后无复发;1例因全身转移于术后8个月死亡。结论:甲状旁腺癌的诊断非常困难,异常高浓度血钙、血PTH及术中浸润表现和组织病理学特征是甲状旁腺癌诊断的重要依据,99m-Tc-MIBI扫描及超声是病变定位的首选手段,肿瘤及其周围受侵组织的“整块切除”(en bloc resection)是首选的治疗方式。

Citation： ZHOU Yang,GONG Rixiang,LUO Shuhua,et al.. The Diagnosis and Treatment of Parathyroid Carcinoma. West China Medical Journal, 2009, 24(3): 579-581. doi: Copy

1.
2.
3.	RAWAT N,KHETAN N,WILLIAMS DW,et al.Parathyroid carcinoma[J].B J Surg,2005,92(11):1345－1353..
4.	MONTENEGRO FL,TAVARES MR,DURAZZO MD,et al.Clinical suspicion and parathyroid carcinoma management[J].Sao Paulo Med J,2006,124(1):42－44..
5.	周建平,田雨霖.中国人原发性甲状旁腺功能亢进10年文献回顾[J].中国普通外科杂志,2007,16(1):78－80..
6.	ELIZABETH A,MITTENDOR F,MCHENRY CR.Parathyroid Carcinoma[J].Adv Anat Pathol,2005,12:53－61..
7.	李进,肖海鹏.甲状旁腺癌研究进展[J].国外医学杂志,2005,32(6):243－246,273..
8.	KEBEBEW E.Parathyroid carcinoma[J].Curr Treat Options Oncol,2001,2:347－354..
9.	FERNANDEZRANVIER GG,KHANAFSHAR E,JENSEN K,et al.Parathyroid carcinoma,atypical parathyroid adenoma,or parathyromatosis?[J]Cancer,2007,110(2):255－264..
10.	THOMPSON SD,PRICHARD AJN.The management of parathyroid carcinoma[J].Curr Opin Otolaryngol Head Neck Surg,2004,12:93－97..
11.	ERICKSON LA,LONG J,WOLLAR P,et al.Parathyroid hyperplasia,adenomas and carcinomas:differential expression of p27Kip1 protein[J].Am J Surg Pathol,1999,23:288－295..
12.	STOJADINOVIC A,HOOS A,NISSAN A,et al.Parathyroid neoplasms:clinical,histopathological and tissue microarraybased molecular analysis[J].Hum Pathol,2003,34:54－64..
13.	VASEF MA,BRYNES RK,STURM M,et al.Expression of cyclin D1 in parathyroid carcinomas,adenomas and hyperplasias[J].Mod Pathol,1999,12:412－416.

1.
2.
3. RAWAT N,KHETAN N,WILLIAMS DW,et al.Parathyroid carcinoma[J].B J Surg,2005,92(11):1345－1353..
4. MONTENEGRO FL,TAVARES MR,DURAZZO MD,et al.Clinical suspicion and parathyroid carcinoma management[J].Sao Paulo Med J,2006,124(1):42－44..
5. 周建平,田雨霖.中国人原发性甲状旁腺功能亢进10年文献回顾[J].中国普通外科杂志,2007,16(1):78－80..
6. ELIZABETH A,MITTENDOR F,MCHENRY CR.Parathyroid Carcinoma[J].Adv Anat Pathol,2005,12:53－61..
7. 李进,肖海鹏.甲状旁腺癌研究进展[J].国外医学杂志,2005,32(6):243－246,273..
8. KEBEBEW E.Parathyroid carcinoma[J].Curr Treat Options Oncol,2001,2:347－354..
9. FERNANDEZRANVIER GG,KHANAFSHAR E,JENSEN K,et al.Parathyroid carcinoma,atypical parathyroid adenoma,or parathyromatosis?[J]Cancer,2007,110(2):255－264..
10. THOMPSON SD,PRICHARD AJN.The management of parathyroid carcinoma[J].Curr Opin Otolaryngol Head Neck Surg,2004,12:93－97..
11. ERICKSON LA,LONG J,WOLLAR P,et al.Parathyroid hyperplasia,adenomas and carcinomas:differential expression of p27Kip1 protein[J].Am J Surg Pathol,1999,23:288－295..
12. STOJADINOVIC A,HOOS A,NISSAN A,et al.Parathyroid neoplasms:clinical,histopathological and tissue microarraybased molecular analysis[J].Hum Pathol,2003,34:54－64..
13. VASEF MA,BRYNES RK,STURM M,et al.Expression of cyclin D1 in parathyroid carcinomas,adenomas and hyperplasias[J].Mod Pathol,1999,12:412－416.

West China Medical Journal

The Diagnosis and Treatment of Parathyroid Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Format

Content