Hepatosplenic γδ T-cell Lymphoma:Report on A Series of 2 Patients and Correlative Literature Review_West China Medical Journal

Authors：

WANG Caixia ,  CHANG Hong.

Department of Hematology,West China Hospital,Sichuan University,Chengdu 610041,China;

Corresponding author：

CHANG Hong., Email: changhonghx@163.com

Keywords：

肝脾γδT细胞淋巴瘤; 病理学特征; 免疫表型

Video：

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目的:探讨肝脾γδT细胞淋巴瘤的临床表现、病理学特征、免疫表型特点。方法:对我院2例确诊的肝脾γδT细胞淋巴瘤患者的临床资料进行分析、追踪随访并进行文献复习。结果:该组患者均为青年男性,肝脾不同程度长大,发热,全血细胞减少(1/2),肝功能受损,淋巴结未受累;病理示瘤细胞弥漫性肝、骨髓的窦内侵犯;免疫表型:患者瘤细胞表达CD2(+)、CD3(+)、CD56(+)、CD16(+)、CD20()、TIA1(+)、TCRγ／δ(+)。结论:肝脾γδT细胞淋巴瘤是较为罕见的外周T细胞淋巴瘤,以肝脾长大、发热为主要临床表现,通常淋巴结不受累,病情进展快,疗效差,生存期短。

Citation： WANG Caixia,CHANG Hong.. Hepatosplenic γδ T-cell Lymphoma:Report on A Series of 2 Patients and Correlative Literature Review. West China Medical Journal, 2009, 24(3): 590-592. doi: Copy

1.	JAFE ES.RALTKIAER E.Hepatosplenic T cell lymphoma.In:Jafe ES,Harris NL,Stein H,et al.World Health Organization classification of tumours.Pathology and genetics of tumours ofheamatopoietic and lymphoid tissues[M].Lyon:IARC Press,2001:210-211..
2.	李精明,陈焯文,庞丹梅,等.原发性肝脾T细胞淋巴瘤三例报告并文献复习[J].白血病.淋巴瘤,2006,15(2):137-138..
3.	BELHADJ K,REYES F,FARCET JP,et al.Hepatosplenic gammadelta Tcell lymphomas is a rare clinicopathologic entity with poor outcome:report on a series of 21 patients[J].Blood,2003,102:4 261-4269..
4.	魏拴增,刘彤华.肝脾γδ和αβ细胞淋巴瘤[J].中华病理学杂志,2003,32(1):62-64..
5.	WEIDMANN E.Hepatosplenic T cell lymphoma.A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990[J].Leukemia,2000,14(6):991-997..
6.	ShuanZeng Wei,TongHua Liu,DeTian Wang,et al.Hepatosplenic γδ Tcell lymphoma[J].World J Gastroenterol,2005,11(24):3729-3734..
7.	GOPCSA L,BANYAI A,TAMASKA J,et al.Hepatosplenic gamma delta Tcekk lymphoma with leukemic phase successfully treated with 2chlorodeoxyadenosine[J].Haematolgia(Budsp),2002,32:519-527..
8.	IANNITTO E,BARBERA V,QUINTINI G,et al.Hepatosplenic gammadelta Tcell lymphoma:complete response induced by treatment with pentoststin[J].Br J Heamatol,2002,117:995996..
9.	GRIGG AP.2’Deoxycoformycin for hepatosplenic gamma delta Tcell lymphoma[J].Leuk Lymphoma,2001,42:797-799..

1. JAFE ES.RALTKIAER E.Hepatosplenic T cell lymphoma.In:Jafe ES,Harris NL,Stein H,et al.World Health Organization classification of tumours.Pathology and genetics of tumours ofheamatopoietic and lymphoid tissues[M].Lyon:IARC Press,2001:210-211..
2. 李精明,陈焯文,庞丹梅,等.原发性肝脾T细胞淋巴瘤三例报告并文献复习[J].白血病.淋巴瘤,2006,15(2):137-138..
3. BELHADJ K,REYES F,FARCET JP,et al.Hepatosplenic gammadelta Tcell lymphomas is a rare clinicopathologic entity with poor outcome:report on a series of 21 patients[J].Blood,2003,102:4 261-4269..
4. 魏拴增,刘彤华.肝脾γδ和αβ细胞淋巴瘤[J].中华病理学杂志,2003,32(1):62-64..
5. WEIDMANN E.Hepatosplenic T cell lymphoma.A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990[J].Leukemia,2000,14(6):991-997..
6. ShuanZeng Wei,TongHua Liu,DeTian Wang,et al.Hepatosplenic γδ Tcell lymphoma[J].World J Gastroenterol,2005,11(24):3729-3734..
7. GOPCSA L,BANYAI A,TAMASKA J,et al.Hepatosplenic gamma delta Tcekk lymphoma with leukemic phase successfully treated with 2chlorodeoxyadenosine[J].Haematolgia(Budsp),2002,32:519-527..
8. IANNITTO E,BARBERA V,QUINTINI G,et al.Hepatosplenic gammadelta Tcell lymphoma:complete response induced by treatment with pentoststin[J].Br J Heamatol,2002,117:995996..
9. GRIGG AP.2’Deoxycoformycin for hepatosplenic gamma delta Tcell lymphoma[J].Leuk Lymphoma,2001,42:797-799..

West China Medical Journal

Hepatosplenic γδ T-cell Lymphoma:Report on A Series of 2 Patients and Correlative Literature Review

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