Megestrol Acetate Used To Prevent Chemotherapyinduced Gastrointestinal Reactions:A Clinical Trial_West China Medical Journal

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Department of Abdominal Oncology,West China Hospital,Sichuan University,Chengdu 610041,China;

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Keywords：

醋酸甲地孕酮; 化疗; 恶心; 呕吐

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目的:观察醋酸甲地孕酮(MA)在预防化疗引起的消化道反应中的作用。方法:收集2007年6月～2008年6月病理学和细胞学证实的消化道恶性肿瘤60例,采用自身前后交叉对照研究,随机分为AB和BA两组。AB组第一周期止吐方案用格拉司琼+胃复安＋MA,第二周期止吐方案用格拉司琼+胃复安;BA组第一周期止吐方案用格拉司琼+胃复安,第二周期止吐方案MA＋格拉司琼+胃复安。结果:化疗同时配合使用MA恶心、呕吐发生率下降(P lt;0.05);恶心、呕吐程度改善(P.001),并且可以预防化疗引起的急性期和延迟期恶心、呕吐反应(P lt;0.05)。结论:化疗同时配合使用MA可以改善化疗患者的恶心呕吐反应

Citation： HOU Ming,ZANG Jian,GOU Hongfeng,et al. Megestrol Acetate Used To Prevent Chemotherapyinduced Gastrointestinal Reactions:A Clinical Trial. West China Medical Journal, 2009, 24(3): 592-594. doi: Copy

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1.
2. SCHNELL FM,Chemotherapyinduced nausea and vomiting:the importance of acute antiemetic control[J].Oncologist,2003,8(2):187-198..
3. GLAUSL A,KNIPPING C,MORANT R,et al.Chemotherapyinduced nausea and vomiting in routine practice:a European perspective[J].Support Care Cancer,2004,12(10):708-715..
4. HESKTH PJ,KRIS MG,GRUNBERG SM,et al.Proposal for classifying the acute emetogenicity of cancer chemotherapy[J].J Clin Oncol,1997,15(1):103-109..
5. AAPRO MS,GRUNBERG SM,MANIKHAS GM,et al.A phase Ⅲ,doubleblind,randomized trial of palonosetron compared with ondansetron in preventing chemotherapyinduced nausea and vomiting following highly emetogenic chemotherapy[J].Ann Oncol,2006,17(9):1441-1449..
6. GRALLA R,LICHINITSER M,SLEEBOOM H,et al.Palonosetron improves prevention of chemotherapyinduced nausea and vomiting following moderately emetogenic chemotherapy:results of a doubleblind randomized phase Ⅲ trial comparing single doses of palonosetron with ondansetron[J].Ann Oncol,2003,14(9):1570-1577..
7. BERENSTEIN EG,RTIZ Z.Megestrol acetate for the treatment of anorexiacachexia syndrome[J].Cochrane Database Syst Rev,2005,(2):CD004310..
8. 孙燕.内科肿瘤学[M].北京:人民卫生出版社,2003:995..
9. 南克俊,魏永长,李春丽,等.甲地孕酮改善晚期恶性肿瘤患者生活质量[J].第四军医大学学报,2002,23(4):350..
10. 邵红玲.格拉司琼与甲氧氯普胺联合应用预防化疗恶心呕吐临床疗效观察[J].实用医技杂志,2007,14(28):3925..
11. 韩冬,郭杰.恩丹西酮预防化疗中胃肠道反应的临床观察[J].河北医学,2004,10(10):930-931..
12. 王梅子,许建衡.化疗止吐药物的研究进展[J].汕头大学医学院学报,2008,21(2):124..
13. 崔慧娟.醋酸甲地孕酮在晚期肿瘤治疗中的应用进展[J].国外医学肿瘤学分册,2001,28(6):473-474..
14. ULUTIN HC,ARPACI F,PAK Y,et al.Megestrol acetate for cachexia and anorexia in advanced non small cell lung cancer:a randomized study comparing two different doses [J].Tumori,2002,88(4):277-280..
15. ROWLAND KMJR,LOPRINZI CL,SHAW EG,et al.Randomized doubleblind placebocontrolled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensivestage smallcell lung cancer:a North Central Cancer Treatment Group study[J].J Clin Oncol,1996,14(1):135-141..
16. 王启船,王青,孙晓,等.甲地孕酮改善肿瘤患者化疗期消化道反应疗效观察[J].中国误诊学杂志,2006,6(23):4572..
17. 何舒.化疗止吐药的研究进展[J].国外医学药学分册,2003,30(6):334..

West China Medical Journal

Megestrol Acetate Used To Prevent Chemotherapyinduced Gastrointestinal Reactions:A Clinical Trial

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