The Relationship between Microalbuminuria and Atherosclerosis in Aged Patients with Essential Hypertension_West China Medical Journal

Authors：

1.Department of Geriatric,West China Hospital,Sichuan University,Chengdu 610041,China;2.The 452 nd Hospital of PLA,Chengdu 610000,China;

Corresponding author：

Keywords：

原发性高血压; 微量白蛋白尿; 颈动脉内中膜厚度; 动脉粥样硬化

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目的:探讨老年原发性高血压(EH)患者早期肾损害指标微量白蛋白尿(MAU)和动脉粥样硬化的早期征象颈动脉内中膜厚度(C-IMT)之间的关系。方法:99名老年EH患者按尿白蛋白/肌酐比值(ACR)分为异常ACR组和正常ACR组,对两组的C-IMT、斑块发生率、ACR水平及血中尿素氮(Bun)、肌酐(Cr)、总胆固醇(TC)、甘油三酯(TG)、血糖(Glu)、体重指数(BMI)等进行分析和比较。结果:异常ACR组的年龄、尿酸、ACR、C-IMT、24小时平均收缩压,平均动脉压及脉压均高于正常ACR组(P lt;0.05);且C-IMT与ACR水平呈正相关(P lt;0.05)。结论:微量白蛋白尿和颈动脉IMT密切相关,提示微量白蛋白尿不仅和老年高血压肾脏病变有关,也是亚临床期动脉粥样硬化的早期标志.

Citation： ZHANG Yan,ZHANG Junqi,ZHONG Liang. The Relationship between Microalbuminuria and Atherosclerosis in Aged Patients with Essential Hypertension. West China Medical Journal, 2009, 24(3): 657-660. doi: Copy

1.	谢秀梅,李志凌,李兢,等.老年原发性高血压微量白蛋白尿与血管内皮功能及颈总动脉粥样硬化[J].高血压杂志,2006,14(2):94-96..
2.	BARGHOUTI N,ELKELES R,NICOLAIDES A,et al.The ultrasonic evaluation of the carotid intimamedia thickness and its relation to risk factors of atherosclerosis in normal and diabetic population[J].Int Angiol,1997,16(1):50-54..
3.	《中国高血压防治指南》修订委员会/高血压的危险分层.中国高血压防治指南2005年修订版[s].北京:人民卫生出版社,2006:15..
4.	SALONNEN JI,SALONEN R.Ultrasound Bmode imaging in observational studies of atherosclerotic progression[J].Circulation,1993,87(3 Suppl):1156-1157..
5.	DEVEREUX RB,LUTAS EM,CASALE PN,et al.Standardization of Mmode echocardiography left ventricular anatomic measurements[J].J Am Coll Cardiol,1984,4(6):1222-1230..
6.	BIGAZZI R,BIANCHI S,CAMPESE VM,et al.Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension[J].Nephron,1992,61:94-97..
7.	JAY PG,GEORGE LB.Microalbuminuria:marker of vascular dysfunction,risk factor for cardiovascular disease [J].Vascular Med,2002,7:35-43..
8.	KLAUSEN K,BORCHJOHNSEN K,FELDTRASMUSSEN B,et al.Very low levels of microalbuminuria are associated with increased riskof coronary heart disease and death independently of renal function,hypertension,and diabetes[J].Circulation,2004,110(1):32-35..
9.	KRISTIAN W,HANS I,MICHAEL H,et al.Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy:the LIFE study[J].Kidney Int Suppl,2004,66(92):S56S58.
10.	张晓梅,胡肇衡,梁红,等.微量白蛋白尿不同测定方法的比较[J].Chinese Journal of Medicinal Guide,2007,9:186-188..
11.	LANGE LA,BOWDEN DW,LANGEFELD CD,et al.Heritability of carotid artery intimamedial thickness in type 2 diabetes [J].Stroke,2002,33(7):1876-1881..
12.	JORGENSEN L,JENSSEN T,JOHNSEN SH,et al.Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in nondiabetic persons:the Tromso Study [J].Eur Heart J,2007,28(3):363-369..
13.	GERSTEIN HC,MANN JF,POGUE J,et al.Prevalence and determinants of microalbuminuria in high risk diabetic and no diabetic patients in heart outcomes prevention evaluation study[J].The HOPE Study Investigators.Diabetes Care,2000,23(supple 2):B35-39..
14.	VIBERTI G,WHEELDON NM,MARVAL STUDY INVESTIGATORS.Microalbumihuria reduction with Vallarta in patients with type 2 diabetes mellitus:a blood pressureindependent effect[J].Circulation,2002,106(6):643-645..
15.	邓先金,曾学丰,缪世海,等.苯那普利与依贝沙坦联合用药对高血压患者尿蛋白、血肌酐清除率,血肌酐的影响[J].高血压杂志,2004,12:400-403..
16.	SEGURA J,RUILOPE LM,RODICIO JL.Microalbuminuria[J].Clin Exp Hypertens,2004,26:701-707..

1. 谢秀梅,李志凌,李兢,等.老年原发性高血压微量白蛋白尿与血管内皮功能及颈总动脉粥样硬化[J].高血压杂志,2006,14(2):94-96..
2. BARGHOUTI N,ELKELES R,NICOLAIDES A,et al.The ultrasonic evaluation of the carotid intimamedia thickness and its relation to risk factors of atherosclerosis in normal and diabetic population[J].Int Angiol,1997,16(1):50-54..
3. 《中国高血压防治指南》修订委员会/高血压的危险分层.中国高血压防治指南2005年修订版[s].北京:人民卫生出版社,2006:15..
4. SALONNEN JI,SALONEN R.Ultrasound Bmode imaging in observational studies of atherosclerotic progression[J].Circulation,1993,87(3 Suppl):1156-1157..
5. DEVEREUX RB,LUTAS EM,CASALE PN,et al.Standardization of Mmode echocardiography left ventricular anatomic measurements[J].J Am Coll Cardiol,1984,4(6):1222-1230..
6. BIGAZZI R,BIANCHI S,CAMPESE VM,et al.Prevalence of microalbuminuria in a large population of patients with mild to moderate essential hypertension[J].Nephron,1992,61:94-97..
7. JAY PG,GEORGE LB.Microalbuminuria:marker of vascular dysfunction,risk factor for cardiovascular disease [J].Vascular Med,2002,7:35-43..
8. KLAUSEN K,BORCHJOHNSEN K,FELDTRASMUSSEN B,et al.Very low levels of microalbuminuria are associated with increased riskof coronary heart disease and death independently of renal function,hypertension,and diabetes[J].Circulation,2004,110(1):32-35..
9. KRISTIAN W,HANS I,MICHAEL H,et al.Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy:the LIFE study[J].Kidney Int Suppl,2004,66(92):S56S58.
10. 张晓梅,胡肇衡,梁红,等.微量白蛋白尿不同测定方法的比较[J].Chinese Journal of Medicinal Guide,2007,9:186-188..
11. LANGE LA,BOWDEN DW,LANGEFELD CD,et al.Heritability of carotid artery intimamedial thickness in type 2 diabetes [J].Stroke,2002,33(7):1876-1881..
12. JORGENSEN L,JENSSEN T,JOHNSEN SH,et al.Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in nondiabetic persons:the Tromso Study [J].Eur Heart J,2007,28(3):363-369..
13. GERSTEIN HC,MANN JF,POGUE J,et al.Prevalence and determinants of microalbuminuria in high risk diabetic and no diabetic patients in heart outcomes prevention evaluation study[J].The HOPE Study Investigators.Diabetes Care,2000,23(supple 2):B35-39..
14. VIBERTI G,WHEELDON NM,MARVAL STUDY INVESTIGATORS.Microalbumihuria reduction with Vallarta in patients with type 2 diabetes mellitus:a blood pressureindependent effect[J].Circulation,2002,106(6):643-645..
15. 邓先金,曾学丰,缪世海,等.苯那普利与依贝沙坦联合用药对高血压患者尿蛋白、血肌酐清除率,血肌酐的影响[J].高血压杂志,2004,12:400-403..
16. SEGURA J,RUILOPE LM,RODICIO JL.Microalbuminuria[J].Clin Exp Hypertens,2004,26:701-707..

West China Medical Journal

The Relationship between Microalbuminuria and Atherosclerosis in Aged Patients with Essential Hypertension

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