Association between Serum Ferritin, Hematological Parameters, Inflammatory Biomarkers, and Metabolic Syndrome in the Aged_West China Medical Journal

Authors：

1.Department of Medical Examination; 2.Department of Cardiology; 3.Department of Neurology, the Second Affiliated Hospital, Jinan Medical University, Shenzhen Guangdong 518020; 4.Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

代谢综合征; 血红蛋白; 白细胞; 老年人

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目的:探讨血清铁蛋白（SF）、红细胞参数（红细胞计数RBC、血红蛋白HGB、红细胞体积MCV）及炎症标志物（白细胞计数WBC、纤维蛋白原FIG、血沉ESR）与老年代谢综合征（MS）的关系。方法:148例老年人,依据MS组分数量多少分为MS0（无MS组分）、MS1～2（有1～2个MS组分）和MS3～5（有3～5个MS组分）三组。测定三组的血SF、空腹血糖FPG、甘油三酯TG、高密度脂蛋白胆固醇HDL-C、RBC、HGB、MCV、WBC、FIG及ESR水平,并进行分析。结果:老年女性及非吸烟老年男性MS组SF、RBC、HGB、WBC及ESR均较MS0组高。老年女性的SF、WBC与腰围,SF、RBC、HGB、WBC与MS组分数量,SF与RBC,均呈正相关。老年非吸烟男性的WBC与TG,HGB与MS组分数量,MCV与BMI及腰围,FIG与BMI,呈正相关。老年人HGB与DBG、TG呈正相关；与HDL-C呈负相关。结论:SF水平与MS发展相关,MS组分数量增加与聚集、超重与肥胖,可能促进体内感染状态。有MS的老年男女,常呈现低度感染状态,但同时又有一定的铁储备及相对稳定的造血机能；无MS的老年男女造血功能倾向减退。老年男性吸烟者较非吸烟者易呈现感染状态,并具有较低的铁储备。

Citation： SUN Yan,LI Jun,LI Gang,et al. Association between Serum Ferritin, Hematological Parameters, Inflammatory Biomarkers, and Metabolic Syndrome in the Aged. West China Medical Journal, 2009, 24(3): 700-704. doi: Copy

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1. JEHN M, CLARK JM, GUALLAR E.Serum ferritin and risk of the metabolic syndrome in U.S.adults[J].Diabetes Care,2004,27（10）:2422-2428..
2. NAGASAWA N, TAMAKOSHI K, YATSUYA H, et al.Association of white blood cell count and clustered components of metabolic syndrome in Japanese men[J].Circ J,2004,68（10）:892-897..
3. 魏玲,杨丽霞,赵颖,等.血红蛋白含量与高血压靶器官损伤[J].高血压杂志,2006,14（5）:360-363..
4. 沈琪琳.老年冠心病患者血液流变学及血细胞参数的观察[J].中国慢性病预防与控制,2000,8（6）:252,289..
5. 孙芾,赵素荣,鲍震霄.健康老年人红细胞分布宽度的探讨[J].中华老年医学杂志,1994,13（1）:45..
6. EISENSTAEDT R, PENNINX BWJH, WOODMAN RC. Anemia in the elderly: current understanding and emerging concepts[J].Blood Reviews,2006,20:213-226..
7. SARNAK MJ, TIGHIOUART H, MANJUNATH G, et al.Anemia as a risk factor for cardiovascular disease in The Atherosclerosis Risk in Communities （ARIC） study[J].J Am Coll Cardiol,2002,40（1）:27-33..
8. 中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中华糖尿病杂志,2004,12（3）:156-161..
9. ALISSA EM, AHMED WH,ALAMA N, et al.Relationship between indices of iron status and coronary risk fators including diabetes and the metabolic syndrome in Saudi subjects without overt coronary disease[J].J Trace Elem Med Biol,2007, 21（4）:242-254.
10. VARI IS, BALKAU B, KETTANEH A, et al. Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an epidemilological Study on the Insulin Resistance syndrome （DESIR）[J]. Diabetes Care,2007,30（7）:1795-1801..
11. WILLIAMS M J, POULTON R, WILLIAMS S. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women[J]. Atherosclerosis,2002,165（1）:179-184..
12. KIM J A, CHOI Y S, HONG J I, et al. Association of metabolic syndrome with white blood cell subtype and red blood cells[J]. Endocr J,2006,53（1）:133-139.
13. MARDI T, TOKER S, MELAMED S, et al. Increased erythropoiesis and subclinical inflammation as part of the metabolic syndrome[J]. Diabetes Res Clin Prac,2005,69（3）:249-155..
14. CUNIETTI E, CHIARI M M, MONTI M, et al. Distortion of iron status indices by acute inflammation in older hospitalized patients[J]. Arch Gerontol Geriatr,2004,39（1）:35-42..
15. SHARP D S, CURB J D, SCHATZ I J, et al. Mean red cell volume as a correlate of blood pressure[J]. Circulation,1996,93（9）:1677-1684..

West China Medical Journal

Association between Serum Ferritin, Hematological Parameters, Inflammatory Biomarkers, and Metabolic Syndrome in the Aged

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