Case-control Study between Estrogen Receptor Gene Polymorphisms and Osteoarthritis in Southern Sichuan High Fluoride Areas_West China Medical Journal

Authors：

YANG Jiexiang , FU Shijie , XIAO Fushen

Affiliated Second Hospital of Luzhou Medical University, Luzhou Sichuan 646000, China;

Corresponding author：

Keywords：

骨关节炎; 雌激素受体基因; 多态性; 氟

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目的:探讨川南高氟地区人群雌激素受体基因PvuⅡ和XbaⅠ核酸限制性内切酶多态性与膝骨性关节炎的相关性。方法:对川南高氟地区41例膝骨性关节炎患者及40例对照组,用聚合酶链反应限制性片段长度多态性(PCR-RFLP)的方法鉴定雌激素受体的基因型,分析雌激素受体基因多态性与膝骨性关节炎的关系及各基因型在病例组与对照组的分布。结果:41例病例组与40例对照组X基因型及P基因型频率分布差异无显著性(P gt;0.05)。结论:川南高氟地区人群ER基因多态性与OA无明确相关性。

Citation： YANG Jiexiang,FU Shijie,XIAO Fushen. Case-control Study between Estrogen Receptor Gene Polymorphisms and Osteoarthritis in Southern Sichuan High Fluoride Areas. West China Medical Journal, 2009, 24(4): 826-829. doi: Copy

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1.  赵喜森.重症难治性休克的机制和治疗[J].中华创伤杂志,2003,19(16):325..
2. VARELA J E, COHN S M, DIAZ I, et al. Splanchnic perfusion during delayed, hypotensive, or aggressive fluid resuscitation from uncontrolled hemorrhage[J]. Shock,2003,20(5):476-480..
3. 王一镗.严重创伤救治的策略-损伤控制性手术[J].中华创伤杂志,2005,21(1):32-35..
4. HOEY B A, SCHWAB C W. Damage control surgery[J]. Scand J Surg,2002,91(1):92-103..
5. WETZEL R C. Multiple trauma in children; critical care overview[J]. Crit Care Med,2002,30:s468-477..
6. WANEK S, MAYBERRY J C. Blunt thoracic trauma: flail chest, pulmonary contusion, and blast injury[J]. Crit Care Clin,2004,20(1):71-81..
7. BUDUHAN G,MCR ITCHIE D I. Missed injuries in patients with multiple trauma [J]. J Trauma,2000,49(3):600-605..
8. 张连阳.努力提高多发伤救治速度[J].中华创伤杂志,2007,23(4):241-243.

West China Medical Journal

Case-control Study between Estrogen Receptor Gene Polymorphisms and Osteoarthritis in Southern Sichuan High Fluoride Areas

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