Association between Interleukin-23 Receptor Gene Polymorphisms and Dilated Cardiomyopathy_West China Medical Journal

Authors：

1.Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China; 2. Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China;

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Keywords：

自身免疫; 基因多态性; 扩张型心肌病

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目的:本文通过研究白介素23受体(IL-23R)基因多态性与扩张型心肌病(DCM)的相关性,探讨DCM患者的免疫遗传学发病机制. 方法:采用PCR-RFLP方法测定DCM患者和正常对照者IL-23R基因rs7517847位点的单核苷酸多态性. 用卡方检验比较病例组与对照组之间基因型频率和等位基因频率的统计学差异。结果:IL-23R基因rs7517847位点单核苷酸多态基因型和等位基因频率在DCM组与正常对照组之间无差异。结论:本研究未发现IL-23R基因rs7517847位点多态性与DCM相关。

Citation： CHEN Yu,PENG Ying,ZHOU Bin,et al. Association between Interleukin-23 Receptor Gene Polymorphisms and Dilated Cardiomyopathy. West China Medical Journal, 2009, 24(4): 870-872. doi: Copy

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1. MARON B J, TOWBIN J A, THIENE G, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention[J]. Circulation,2006,113:1807-16..
2. FU M. Autoimmunity in idiopathic dilated cardiomyopathy: from patients to molecules and back to patients[J]. Int J Cardiol, 2006, 112:1..
3. PARHAM C, CHIRICA M, TIMANS J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R[J]. J Immunol, 2002, 168(11):5699-5708..
4. OPPMANN B, LESLEY R, BLOM B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12[J]. Immunity,2000,13:715-725..
5. PARK H, LI ZX, YANG XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing Interleukin 17[J]. Nat lmmunol, 2005, 6(11):1133-1141..
6. LANGRISH CL, CHEN Y, BLUMENSCHEIN WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].J Exp Med, 2005, 201: 233-240..
7. SONDEREGGER I, ROHN, TA, KURRER MO, et al.Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis[J]. Eur J Immunol, 2006, 36(11): 2849-2856..
8. RANGACHARI M,MAUERMANN N,MARTY RR,et al.T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17[J].J Exp Med, 2006, 203(8): 2009 -2019..

West China Medical Journal

Association between Interleukin-23 Receptor Gene Polymorphisms and Dilated Cardiomyopathy

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