Clinical Study of Chaiqin Chengqi Decoction in Treating Severe Acute Pancreatitis Accompanied with Multiple Organ Dysfunction Syndrome in Early Stage_West China Medical Journal

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Department of Integrated Traditional Chinese and Western Medicine,West China Hospital,Sichuan University, Chengdu 610041, China;

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Keywords：

重症急性胰腺炎; 多器官功能障碍综合征; 柴芩承气汤; 临床研究

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目的:探讨早期应用柴芩承气汤治疗重症急性胰腺炎(severe acute pancreatitis,SAP)伴多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)的临床疗效。方法:88例符合病例选择标准并接受柴芩承气汤治疗的SAP伴MODS住院患者,按院外病程长短分为早期组(48 h内入院接受治疗,44例)和晚期组(48～72 h内入院接受治疗,44例),比较治疗过程中两组患者器官功能障碍持续时间、住院时间、感染率、中转手术率及病死率。结果:早期组急性呼吸窘迫综合征、肾功能衰竭、心功能衰竭、肝功能不全、脑病、凝血系统损害的持续时间低于晚期组(P lt;0.05);早期组住院时间、感染率、中转ICU率、中转手术率及病死率低于晚期组(P lt;0.05)。结论:早期应用柴芩承气汤治疗SAP伴MODS能减少器官损害持续时间,减轻器官损害,从而缩短病程,减少后期感染率及中转手术率,降低病死率。

Citation： CHEN Yan,HUANG Zongwen,GUO Jia,et al. Clinical Study of Chaiqin Chengqi Decoction in Treating Severe Acute Pancreatitis Accompanied with Multiple Organ Dysfunction Syndrome in Early Stage. West China Medical Journal, 2009, 24(4): 909-911. doi: Copy

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2.	王今达,王宝恩. MODS病情分期诊断及严重程度评分标准[J].中国危重病急救医学,1995,7(6): 346-347..
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5.	刘续宝,蒋俊明,黄宗文,等.中西医结合治疗重症急性胰腺炎的临床研究(附1376 例报告) [J].四川大学学报(医学版),2004,35 (2):204-208..
6.	薛平,黄宗文,郭佳,等.早期应用柴芩承气汤治疗胆源性重症急性胰腺炎的临床研究[J].中西医结合学报,2005,3(4):263-265..

1. TOOULI J, BROOKE-SMITH M, BASSI C, et al.Guidelines forthe management of acute pancreatitis[J]. J Gast roenterolHepatol,2002,17 Suppl: S15-S39..
2. 王今达,王宝恩. MODS病情分期诊断及严重程度评分标准[J].中国危重病急救医学,1995,7(6): 346-347..
3. 季大玺,谢红浪,黎磊石.连续性血液净化与非肾脏病[J].中国危重症急救医学, 2001,13 (1): 5-9..
4. BONE RC. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation[J].Crit Care Med,1996,24(1): 163-172..
5. 刘续宝,蒋俊明,黄宗文,等.中西医结合治疗重症急性胰腺炎的临床研究(附1376 例报告) [J].四川大学学报(医学版),2004,35 (2):204-208..
6. 薛平,黄宗文,郭佳,等.早期应用柴芩承气汤治疗胆源性重症急性胰腺炎的临床研究[J].中西医结合学报,2005,3(4):263-265..

West China Medical Journal

Clinical Study of Chaiqin Chengqi Decoction in Treating Severe Acute Pancreatitis Accompanied with Multiple Organ Dysfunction Syndrome in Early Stage

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